The association of circulating ferritin with serum concentrations of fibroblast growth factor-23 measured by three commercial assays

Durham, B; Joseph, Frank; Bailey, Lisa M.; Fraser, William D.

doi:10.1258/000456307781646102

Cited by 69 publications

(52 citation statements)

References 16 publications

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“…In boys, high testosterone secretion in infancy could partly explain increased hematopoiesis and higher consumption of iron. Serum iron concentrations may participate in the regulation of FGF23 metabolism [37,38,39], and low serum ferritin is associated with high C-terminal FGF23 concentration [40,41]. In our study, C-terminal FGF23 and hemoglobin showed no association.…”

Section: Discussioncontrasting

confidence: 56%

Fibroblast Growth Factor 23 Concentrations Reflect Sex Differences in Mineral Metabolism and Growth in Early Infancy

Holmlund-Suila

Viljakainen²,

Ljunggren

et al. 2016

Horm Res Paediatr

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Background: The role of fibroblast growth factor 23 (FGF23) in the regulation of mineral homeostasis in early life is inadequately understood. We aimed to explore the effects of vitamin D supplementation on serum FGF23 and to elucidate longitudinal changes in FGF23, in addition to studying its association with mineral metabolism in early infancy. Methods: Altogether 113 healthy infants received vitamin D₃ 10, 30 or 40 µg/day from age 0.5 to 3.0 months. Cord blood at birth and capillary blood samples at 3 months were analyzed for serum 25-hydroxyvitamin D, parathyroid hormone, phosphate, calcium and intact and C-terminal FGF23. Results: In repeated-measures ANCOVA, intact FGF23 concentration increased with time (p < 0.001) and C-terminal FGF23 decreased (p < 0.001). At 3 months, girls had a higher concentration of intact FGF23 (51 vs. 26 pg/ml, p < 0.001) and a greater increase over time (ΔFGF23 intact 45 vs. 16 pg/ml, p = 0.001) than boys. Vitamin D did not affect serum intact or C-terminal FGF23 concentrations. Girls showed a positive correlation between phosphate and intact FGF23 (p = 0.004), whereas in boys phosphate and C-terminal FGF23 correlated inversely (p = 0.006). Conclusions: A substantial sex-related difference in intact FGF23 concentration exists during early infancy, possibly related to differences in skeletal growth between boys and girls.

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Section: Discussioncontrasting

confidence: 56%

Fibroblast Growth Factor 23 Concentrations Reflect Sex Differences in Mineral Metabolism and Growth in Early Infancy

Holmlund-Suila

Viljakainen²,

Ljunggren

et al. 2016

Horm Res Paediatr

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“…In a study an important diurnal variation is detected in iFGF-23 so the use of cFGF-23 is thought to be more useful in clinical practice 52 . Also both immunotrophic assays are thought to be affected from ferritin levels but this situation does not occur in kainos iFGF-23 assay 53 . As a result of these data we think the use of both iFGF-23 assay and cFGF-23 assay together may be suitable.…”

Section: Discussionmentioning

confidence: 99%

Fibroblast growth factor is associated to left ventricular mass index, anemia and low values of transferrin saturation

et al. 2015

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“…The latter may also be an important confounder in this study. It has been postulated that iron may be an important regulator of fibroblast growth factor-23 (FGF-23) [34,35]. Since FGF-23 may regulate PTH secretion [36], adjusting for the effects of iron and/or FGF-23 would enhance our study, particularly since the secretion of FGF-23 may be modified by diabetic status [37].…”

Section: Discussionmentioning

confidence: 99%

The Association between Parathyroid Hormone Levels and Hemoglobin in Diabetic and Nondiabetic Participants in the National Kidney Foundationʼs Kidney Early Evaluation Program

Memon

Norris²,

Bomback³

et al. 2013

Cardiorenal Med

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Background: Both anemia and secondary hyperparathyroidism are reflections of hormonal failure in chronic kidney disease (CKD). While the association of elevated levels of parathyroid hormone (PTH) and anemia has been studied among those with advanced CKD, less is known about this association in mild-to-moderate CKD. Methods: In a cross-sectional analysis, the relationship between PTH and hemoglobin levels was investigated in 10,750 participants in the National Kidney Foundationʼs Kidney Early Evaluation Program with an estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m². Results: In the unadjusted analysis, higher PTH levels were associated with lower hemoglobin levels. However, after multivariable adjustment for age, race, gender, smoking status, education, cardiovascular disease, diabetes, hypertension, cancer, albuminuria, BMI, baseline eGFR, calcium, and phosphorus, the direction of association changed. As compared to the first PTH quintile, hemoglobin levels were 0.09 g/dl (95% CI: 0.01-0.18), 0.15 g/dl (95% CI: 0.07-0.24), 0.18 g/dl (95% CI: 0.09-0.26), and 0.13 g/dl (95% CI: 0.07-0.25) higher for the second, third, fourth, and fifth quintiles, respectively. Similarly, each standard deviation increase in natural log transformed PTH was associated with a 0.06 g/dl (95% CI: 0.03-0.09, p = 0.0003) increase in hemoglobin. However, a significant effect modification was seen for diabetes (p = 0.0003). Each standard deviation increase in natural log transformed PTH was associated with a 0.10 g/dl (95% CI: 0.054-0.138, p < 0.0001) increase in hemoglobin, while no association was seen among those without diabetes mellitus. Conclusion: After multivariable adjustment, there was a small positive association between PTH and hemoglobin among diabetics but not among nondiabetics.

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The association of circulating ferritin with serum concentrations of fibroblast growth factor-23 measured by three commercial assays

Cited by 69 publications

References 16 publications

Fibroblast Growth Factor 23 Concentrations Reflect Sex Differences in Mineral Metabolism and Growth in Early Infancy

Fibroblast Growth Factor 23 Concentrations Reflect Sex Differences in Mineral Metabolism and Growth in Early Infancy

Fibroblast growth factor is associated to left ventricular mass index, anemia and low values of transferrin saturation

The Association between Parathyroid Hormone Levels and Hemoglobin in Diabetic and Nondiabetic Participants in the National Kidney Foundationʼs Kidney Early Evaluation Program

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