The association of Chlamydia trachomatis and human papillomavirus co-infection with abnormal cervical cytology among women in south of Morocco

Ferrera, Laila; Rogua, Hanane; Mansouri, Nezha El; Kassidi, Farid; Aksim, Mohamed; Farouqi, A; Chouham, Said; Nejmeddine, Mohamed

doi:10.1016/j.micpath.2023.105971

Cited by 7 publications

(7 citation statements)

References 39 publications

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“…These studies suggested that CT is more prevalent in women who are infected with HPV than in those who are not, so it makes HPV as a risk factor for CT infection, and conversely 224,225 . Furthermore, several studies demonstrated an association between HPV/CT co‐infection and developing abnormal cervical cytology and dysplasia 213,226,227 . The HPV and CT DNAs can be detected in approximately 99% of cervical cancer cases 228,229 .…”

Section: Microbiome and Hpvmentioning

confidence: 99%

“…224,225 Furthermore, several studies demonstrated an association between HPV/CT co-infection and developing abnormal cervical cytology and dysplasia. 213,226,227 The HPV and CT DNAs can be detected in approximately 99% of cervical cancer cases. 228,229 There is a mutual benefit in HPV/CT co-infection.…”

Section: Hpv/c Trachomatis Co-infectionmentioning

confidence: 99%

“…194,222,223 The connection between CT infection and HPV retention was studied in various regions of the world. 213,[224][225][226][227] These studies suggested that CT is more prevalent in women who are infected with HPV than in those who are not, so it makes HPV as a risk factor for CT infection, and conversely. 224,225 Furthermore, several studies demonstrated an association between HPV/CT co-infection and developing abnormal cervical cytology and dysplasia.…”

Section: Hpv/c Trachomatis Co-infectionmentioning

confidence: 99%

“…Although it is frequently asymptomatic, genital CT infection in women has been associated with several severe diseases including tubal factor infertility, pelvic inflammatory disease, chronic pelvic pain, ectopic pregnancy, venereal lymphogranuloma, uterine cervical lesions, newborn pneumonia, trachoma, and conjunctivitis 194,222,223 . The connection between CT infection and HPV retention was studied in various regions of the world 213,224–227 . These studies suggested that CT is more prevalent in women who are infected with HPV than in those who are not, so it makes HPV as a risk factor for CT infection, and conversely 224,225 .…”

Section: Microbiome and Hpvmentioning

confidence: 99%

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HPV co‐infections with other pathogens in cancer development: A comprehensive review

Akbari,

Milani,

Seyedinkhorasani

et al. 2023

Journal of Medical Virology

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High‐risk human papillomaviruses (HR‐HPVs) cause various malignancies in the anogenital and oropharyngeal regions. About 70% of cervical and oropharyngeal cancers are caused by HPV types 16 and 18. Notably, some viruses including herpes simplex virus, Epstein–Barr virus, and human immunodeficiency virus along with various bacteria often interact with HPV, potentially impacting its replication, persistence, and cancer progression. Thus, HPV infection can be significantly influenced by co‐infecting agents that influence infection dynamics and disease progression. Bacterial co‐infections (e.g., Chlamydia trachomatis) along with bacterial vaginosis‐related species also interact with HPV in genital tract leading to viral persistence and disease outcomes. Co‐infections involving HPV and diverse infectious agents have significant implications for disease transmission and clinical progression. This review explores multiple facets of HPV infection encompassing the co‐infection dynamics with other pathogens, interaction with the human microbiome, and its role in disease development.

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Section: Microbiome and Hpvmentioning

confidence: 99%

Section: Hpv/c Trachomatis Co-infectionmentioning

confidence: 99%

Section: Hpv/c Trachomatis Co-infectionmentioning

confidence: 99%

Section: Microbiome and Hpvmentioning

confidence: 99%

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HPV co‐infections with other pathogens in cancer development: A comprehensive review

Akbari,

Milani,

Seyedinkhorasani

et al. 2023

Journal of Medical Virology

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“…Isso acontece pois o sistema imune do hospedeiro consegue eliminar o vírus. Em alguns casos, a depender do genótipo oncogênico do HPV, a infecção viral pode persistir e evoluir para o câncer de colo uterino (CCU) (Ferrera, et al, 2023).…”

Section: Introductionunclassified

Papillomavirus humano e coinfecções por Chlamydia trachomatis e Gardnerella vaginalis em mulheres atendidas em um laboratório particular na cidade de Aracaju-Sergipe, Brasil

Santos,

Santana,

Santana

et al. 2024

RSD

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O papillomavirus humano (HPV) está associado ao desenvolvimento do câncer de colo uterino, em que diferentes fatores podem estar associados com a persistência, potencialização e a progressão de lesões pré-cancerosas, um destes fatores são as coinfecções entre HPV, Chlamydia trachomatis (CT) e Gardnerella vaginalis (GV). Assim, o objetivo do trabalho é verificar a incidência do HPV e as coinfecções por CT e GV em mulheres atendidas em um laboratório particular de Aracaju, localizada no estado de Sergipe. O estudo é do tipo descritivo, transversal e retrospectivo, sendo analisados os resultados dos exames para a genotipagem de HPV alto risco, pesquisa de CT e o exame citopatológico, que foram realizados no período entre janeiro à outubro de 2022. No período de estudo, 1.312 mulheres realizaram a coleta de secreção vaginal, sendo detectado outros genótipos de alto risco oncogênico do HPV que não 16 e/ou 18 em 80,65% (296/367) dos casos, seguido do HPV-16 com 8,71% (32/367) e HPV-18 com 3,82% (14/367). Dentre as pacientes infectadas por HPV, houve 30,7% (113/367) casos de coinfecções com 14,16% (16/113) por CT e 81,42% (92/113) por GV, além dos achados de tripla infecção, em 4,42% (5/113) dos casos. Assim, foi observado que houve uma maior incidência de outros genótipos do HPV que não 16 e/ou 18, além de ser encontrado casos de coinfecções duplas e triplas nas mulheres atendidas no laboratório.

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The Vaginal Microbiota, Human Papillomavirus Infection, and Cervical Carcinogenesis: A Systematic Review in the Latina Population

Mancilla,

Jimenez,

Bishop

et al. 2024

J Epidemiol Glob Health

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Background Latina women experience disproportionately higher rates of HPV infection, persistence, and progression to cervical dysplasia and cancer compared to other racial–ethnic groups. This systematic review explores the relationship between the cervicovaginal microbiome and human papillomavirus infection, cervical dysplasia, and cervical cancer in Latinas. Methods The review abides by the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. PubMed, EMBASE, and Scopus databases were searched from January 2000 through November 11, 2022. The review included observational studies reporting on the cervicovaginal microbiota in premenopausal Latina women with human papillomavirus infection, cervical dysplasia, and cervical cancer. Results Twenty-five articles were eligible for final inclusion (N = 131,183). Forty-two unique bacteria were reported in the cervicovaginal microbiome of Latinas. Seven bacteria: Lactobacillus crispatus, Lactobacillus iners, Chlamydia trachomatis, Prevotella spp., Prevotella amnii, Fusobacterium spp. and Sneathia spp. were enriched across multiple stages of cervical carcinogenesis in Latinas. Therefore, the total number of reported bacteria includes four bacteria associated with the healthy state, 16 bacteria enriched in human papillomavirus outcomes, 24 unique bacteria associated with abnormal cytology/dysplasia, and five bacteria associated with cervical cancer. Furthermore, three studies reported significantly higher alpha and beta diversity in Latinas with cervical dysplasia and cancer compared to controls. Lactobacillus depletion and an increased abundance of L. iners in Latinas compared to non-Latinas, regardless of human papillomavirus status or lesions, were observed. Conclusions The identification of 42 unique bacteria and their enrichment in cervical carcinogenesis can guide future cervicovaginal microbiome research to better inform cervical cancer prevention strategies in Latinas.

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The association of Chlamydia trachomatis and human papillomavirus co-infection with abnormal cervical cytology among women in south of Morocco

Cited by 7 publications

References 39 publications

HPV co‐infections with other pathogens in cancer development: A comprehensive review

HPV co‐infections with other pathogens in cancer development: A comprehensive review

Papillomavirus humano e coinfecções por Chlamydia trachomatis e Gardnerella vaginalis em mulheres atendidas em um laboratório particular na cidade de Aracaju-Sergipe, Brasil

The Vaginal Microbiota, Human Papillomavirus Infection, and Cervical Carcinogenesis: A Systematic Review in the Latina Population

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