Internet Gaming Disorder (IGD) is a significant mental health concern. This cross-sectional study tested the indirect effects of childhood maltreatment on distress tolerance, neuroticism, and IGD symptoms in a sample of 475 young adult daily gamers (ages 18–25). We hypothesized the direct effects of childhood maltreatment on distress tolerance and IGD symptoms and an indirect effect of childhood maltreatment on IGD symptoms via distress tolerance. Significant direct effects from trait neuroticism to IGD symptoms were expected; trait neuroticism was hypothesized to strengthen the relationship between distress tolerance and IGD symptoms. No paths were freed post hoc. The results supported all hypothesized direct effects except neuroticism on IGD; the indirect effect of childhood maltreatment via distress tolerance was also supported. As expected, the effect of distress tolerance on IGD symptoms was moderated by neuroticism, particularly at low and average levels of neuroticism. The manuscript discusses our findings in greater detail, and treatment recommendations are offered.