The association of bone mineral density with insulin resistance in patients with polycystic ovary syndrome

Noyan, Volkan; Yücel, Aykan; Sağsöz, Nevin

doi:10.1016/j.ejogrb.2004.01.031

Cited by 29 publications

(27 citation statements)

References 18 publications

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“…However, contrary to other studies [4, 6, 22, 24] the mean insulin concentrations were comparable in both analyzed groups. In both groups insulin levels were within the normal range.…”

Section: Discussioncontrasting

confidence: 99%

“…These results support the findings of Yüksel et al [6] and Kirchengast et al [16]. Most prior studies suggest that the BMD is increased in women with PCOS [7, 10, 18–21] or that total BMD does not differ significantly in PCOS subjects compared with healthy controls [18, 22]. Probably, the causes of the discrepancies we have found are the different inclusion criteria of PCOS women, as well as differences in age, BMI and menstrual irregularities among the examined women [2, 23].…”

Section: Discussionsupporting

confidence: 90%

“…Many of previous studies were performed in women with excessive body weight [21, 22, 24, 25]. In the present study, the PCOS patients were divided into subgroups according to their BMI, to assess the impact of the body mass index on the bone parameters.…”

Section: Discussionmentioning

confidence: 99%

“…Yüksel et al [6] postulated that insulin resistance and/or hyperinsulinemia might be associated with the relative preservation of bone density in PCOS women. Also Noyan et al [22], found that insulin resistance may play a role in BMD preservation in PCOS patients. Hyperinsulinemia/insulin resistance may stimulate osteoblast cells activity directly and indirectly via a suppression of the production of the sex hormone binding globulin (SHBG) and the insulin-like growth factor binding protein (IGFBP).…”

Section: Discussionmentioning

confidence: 99%

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Bone mineral density in women with polycystic ovary syndrome

Kołodziejczyk

Sławek

Czyźyk

et al. 2014

J Endocrinol Invest

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PurposePCOS is a complex disorder and various features of this disorder may have great importance for bone metabolism. The aim of the study was to determine the relationship between existing hormonal disorders, and bone mineral density (BMD) in young women with PCOS.Methods69 reproductive-aged PCOS women and 30 age-matched healthy controls were enrolled to the study women. In each individual we assessed the body mass index (BMI). We evaluated the serum concentrations of: gonadotropins, prolactin (PRL), estradiol (E2), dehydroepiandrosterone sulfate (DHEAS), testosterone (T), thyroid stimulating hormone (TSH), free thyroxine (fT4). We used the Homeostatic Model Assessment–Insulin Resistance Index (HOMA–IR) to diagnose insulin resistance. Bone mineral density in the lumbar spine was measured by dual-energy X-ray absorptiometry (DXA).ResultsThe PCOS women had lower BMD values as compared to the controls (1.057 ± 0.1260 vs. 1.210 ± 0.1805 g/cm2, p < 0.0002). In the analysis of PCOS patients according to BMI, only in the subgroup of the normal weight PCOS we find significantly lower BMD in comparison to controls (p = 0.0049). In patients with PCOS, BMD was positively correlated with insulin concentration and HOMA–IR. In the controls Z-score values were positively correlated with insulin concentration and HOMA–IR.ConclusionsThe deleterious effect of estrogen deficiency on bones in PCOS is not balanced by androgen overproduction. Women with PCOS had significantly lower BMD of the lumbar spine compared to controls. Insulin seems to be one of the most important positive bone growth stimulators.

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“…However, contrary to other studies [4, 6, 22, 24] the mean insulin concentrations were comparable in both analyzed groups. In both groups insulin levels were within the normal range.…”

Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Bone mineral density in women with polycystic ovary syndrome

Kołodziejczyk

Sławek

Czyźyk

et al. 2014

J Endocrinol Invest

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“…BMD & fracture risk in PCOS & hirsutism BMD was evaluated in premenopausal patients with hirsutism and/or PCOS compared to controls with regular menses in several previous studies [14][15][16][17][18][19][20][21][22][23][24] presented in (TABLE 1). Studies without a healthy control group are not included in the table.…”

mentioning

confidence: 99%

Bone mineral density and vitamin D in PCOS and hirsutism

Glintborg

Hermann

Andersen

2013

Expert Review of Endocrinology & Metabolism

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Polycystic ovary syndrome (PCOS) is the most frequent endocrinopathy in reproductive-aged women. The majority of hirsute patients are diagnosed with PCOS. Hyperandrogenemia, central obesity and insulin resistance may protect patients with PCOS from osteoporosis, whereas increased cortisol levels, low growth hormone and amenorrhea may be associated with decreased bone mineral density (BMD). Recent studies suggested that insulin resistance in PCOS is associated with decreased vitamin D levels that could not be explained by obesity alone. Vitamin D treatment may therefore have positive effects on insulin sensitivity and perhaps also hyperandrogenemia in patients with PCOS. In the present article, we review the evidence of changed BMD, bone mineral turnover and vitamin D status in PCOS and hirsutism compared with healthy women and the effects of medical intervention on BMD in PCOS.

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The Relationship Between Polycystic Ovarian Syndrome, Periodontal Disease, and Osteoporosis

Young

Ward

2020

Reprod. Sci.

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The association of bone mineral density with insulin resistance in patients with polycystic ovary syndrome

Cited by 29 publications

References 18 publications

Bone mineral density in women with polycystic ovary syndrome

Bone mineral density in women with polycystic ovary syndrome

Bone mineral density and vitamin D in PCOS and hirsutism

The Relationship Between Polycystic Ovarian Syndrome, Periodontal Disease, and Osteoporosis

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