The association of body mass index, waist and hip circumference, and waist–hip ratio with Chlamydia pneumoniae IgG antibodies and high-sensitive C-reactive protein at 31 years of age in Northern Finland Birth Cohort 1966

Lajunen, Taina K.; Bloigu, Aini; Paldanius, Mika; Pouta, Anneli; Laitinen, Jaana; Ruokonen, Aimo; Al, Hartikainen; Savolainen, Markku J.; Kh, Herzig; Leinonen, Maija; Saikku, Pekka; Järvelin, Marjo‐Riitta

doi:10.1038/ijo.2011.21

Cited by 7 publications

(2 citation statements)

References 43 publications

(73 reference statements)

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“…A direct role on the host's metabolism reprogramming towards adipogenesis has been put forward as a causative or inducing factor of obesity. The existence of circulating antibodies against certain infectious agents (e.g., Chlamydia pneumoniae and adenovirus-36) has been associated with the suffering of excess weight [58,59]. Viral agents involved in the genesis of obesity can be classified into five main categories expanding from Adenoviruses and Herpes viruses to phages, slow viruses of transmissible spongiform encephalopathies, and other encephalitides, as well as hepatitides.…”

Section: Infectobesitymentioning

confidence: 99%

Time to Consider the “Exposome Hypothesis” in the Development of the Obesity Pandemic

et al. 2022

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The obesity epidemic shows no signs of abatement. Genetics and overnutrition together with a dramatic decline in physical activity are the alleged main causes for this pandemic. While they undoubtedly represent the main contributors to the obesity problem, they are not able to fully explain all cases and current trends. In this context, a body of knowledge related to exposure to as yet underappreciated obesogenic factors, which can be referred to as the “exposome”, merits detailed analysis. Contrarily to the genome, the “exposome” is subject to a great dynamism and variability, which unfolds throughout the individual’s lifetime. The development of precise ways of capturing the full exposure spectrum of a person is extraordinarily demanding. Data derived from epidemiological studies linking excess weight with elevated ambient temperatures, in utero, and intergenerational effects as well as epigenetics, microorganisms, microbiota, sleep curtailment, and endocrine disruptors, among others, suggests the possibility that they may work alone or synergistically as several alternative putative contributors to this global epidemic. This narrative review reports the available evidence on as yet underappreciated drivers of the obesity epidemic. Broadly based interventions are needed to better identify these drivers at the same time as stimulating reflection on the potential relevance of the “exposome” in the development and perpetuation of the obesity epidemic.

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Section: Infectobesitymentioning

confidence: 99%

Time to Consider the “Exposome Hypothesis” in the Development of the Obesity Pandemic

et al. 2022

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“…Covariates in our study included age, gender, race/ethnicity (Caucasian, Chinese, African-American, and Hispanic), education (11th grade or less, high school graduate, some college/associate degree, or college graduate), body mass index (BMI), pack-years of smoking, low-density lipoprotein cholesterol, systolic blood pressure, diastolic blood pressure, exercise (METS, min/week), current alcohol use, CAC at baseline examination, and ABI at baseline examination. 21 BMI was calculated as weight in kilograms divided by height squared in metres. Height and weight were measured in light clothing and with no shoes.…”

Section: Covariatesmentioning

confidence: 99%

Chlamydia pneumoniae and progression of subclinical atherosclerosis

Player

Mainous

Everett

et al. 2012

Eur J Prev Cardiolog

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Different associations of subscapular and triceps skinfold thicknesses with pathogen load: An ecogeographical analysis

Wells¹,

Cortina‐Borja²

2013

American J Hum Biol

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Across populations, higher pathogen load was associated with reduced central but not peripheral skinfolds, supporting the hypothesis that central adiposity is more closely associated with immune function. This scenario might explain why some populations increase disproportionately in central adiposity when the environment shifts from low-energy high-pathogen status to high-energy low-pathogen status.

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The association of body mass index, waist and hip circumference, and waist–hip ratio with Chlamydia pneumoniae IgG antibodies and high-sensitive C-reactive protein at 31 years of age in Northern Finland Birth Cohort 1966

Cited by 7 publications

References 43 publications

Time to Consider the “Exposome Hypothesis” in the Development of the Obesity Pandemic

Time to Consider the “Exposome Hypothesis” in the Development of the Obesity Pandemic

Chlamydia pneumoniae and progression of subclinical atherosclerosis

Different associations of subscapular and triceps skinfold thicknesses with pathogen load: An ecogeographical analysis

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