The Association of Bisphenol A and Parabens Exposure and Oxidative Stress in Attention-Deficit/Hyperactivity Disorder in Children and Adolescents

Subramani, Boopathi; Chang, Ching Chih; Fang, Ting-Yu; Yu, Ching-Jung; Du, Jung‐Chieh; Chiou, Hsien-Chih; Hou, Jingwen; Yang, Winnie; Chen, Hsin‐Chang; Chen, Ying-Sheue; Hwang, Betau; Chen, Mei-Lien

doi:10.1007/s12403-023-00561-0

Cited by 1 publication

(1 citation statement)

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“…However, despite the availability of knowledge regarding the diverse mechanisms of ADHD, its pathogenesis is not fully understood, so correct early diagnosis and provision of accurate clinical management are challenging ( Kessi et al, 2022 ). Recent papers have speculated a strong correlation between BPA treatment and behavioral/cognitive dysfunction in children with ADHD ( Tewar et al, 2016 ; Rochester et al, 2018 ; Yoo et al, 2020 ; Subramani et al, 2023 ). Life-course analysis revealed that a diet containing BPA led to an increase in energy expenditure in mice and was associated with hyperactive and lean phenotypes ( Anderson et al, 2013 ).…”

Section: Phenols and Neuropsychiatric Disordersmentioning

confidence: 99%

Phenols and GABAA receptors: from structure and molecular mechanisms action to neuropsychiatric sequelae

Menzikov,

Zaichenko,

Moskovtsev

et al. 2024

Front. Pharmacol.

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γ-Aminobutyric acid type A receptors (GABAARs) are members of the pentameric ligand-gated ion channel (pLGIC) family, which are widespread throughout the invertebrate and vertebrate central nervous system. GABAARs are engaged in short-term changes of the neuronal concentrations of chloride (Cl−) and bicarbonate (HCO3−) ions by their passive permeability through the ion channel pore. GABAARs are regulated by various structurally diverse phenolic substances ranging from simple phenols to complex polyphenols. The wide chemical and structural variability of phenols suggest similar and different binding sites on GABAARs, allowing them to manifest themselves as activators, inhibitors, or allosteric ligands of GABAAR function. Interest in phenols is associated with their great potential for GABAAR modulation, but also with their subsequent negative or positive role in neurological and psychiatric disorders. This review focuses on the GABAergic deficit hypotheses during neurological and psychiatric disorders induced by various phenols. We summarize the structure–activity relationship of general phenol groups concerning their differential roles in the manifestation of neuropsychiatric symptoms. We describe and analyze the role of GABAAR subunits in manifesting various neuropathologies and the molecular mechanisms underlying their modulation by phenols. Finally, we discuss how phenol drugs can modulate GABAAR activity via desensitization and resensitization. We also demonstrate a novel pharmacological approach to treat neuropsychiatric disorders via regulation of receptor phosphorylation/dephosphorylation.

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