The association of biologically active lipids with the development of transfusion‐related acute lung injury: a retrospective study

Silliman, Christopher C.; Paterson, Andrew J.; Dickey, William O.; Stroncek, David F.; Popovsky, Mark; Caldwell, Sherrie; Ambruso, Daniel R.

doi:10.1046/j.1537-2995.1997.37797369448.x

Cited by 410 publications

(466 citation statements)

References 20 publications

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“…The second theory is that neutrophils are activated by biologically active lipids such as lysophosphatidylcholines that are released from cell membranes as stored blood products break down over time. 150,153 In support of this hypothesis, several studies have suggested that blood products that are stored longer may be more likely to produce TRALI in at-risk groups such as trauma 154 and severe sepsis patients. 155 …”

Section: Alcohol Abusementioning

confidence: 96%

Pathophysiology of Acute Lung Injury and the Acute Respiratory Distress Syndrome

Ware¹

2006

Semin Respir Crit Care Med

430

324

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Since the adult respiratory distress syndrome was first described substantial progress has been made in understanding the pathogenesis of this complex syndrome. This review summarizes our current understanding of the pathophysiology of what is now termed the acute respiratory distress syndrome (ARDS) and its less severe form acute lung injury (ALI), with an emphasis on cellular and molecular mechanisms of injury that may represent potential therapeutic targets. Although it is difficult to synthesize all of these abnormalities into a single, unified, pathogenetic pathway, a theme that emerges repeatedly is that of imbalance, be it between pro-and anti-inflammatory cytokines, oxidants and antioxidants, procoagulants and anticoagulants, neutrophil recruitment and activation and mechanisms of neutrophil clearance, or proteases and protease inhibitors. Future therapies aimed at restoring the overall balance of cytokines, oxidants, coagulants, and proteases may ultimately be successful where therapies that target individual cytokines or other mediators have not.

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Section: Alcohol Abusementioning

confidence: 96%

Pathophysiology of Acute Lung Injury and the Acute Respiratory Distress Syndrome

Ware¹

2006

Semin Respir Crit Care Med

430

324

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“…7,15,20 An alternative mechanism involves accumulation of bioactive lipids (lysophosphatidylcholines [lysoPCs]) during storage of cell containing blood products. [21][22][23] Cardiac surgery patients may be at risk for TRALI. During the intrathoracic surgical procedure, the lungs are deflated and nonventilated for several hours, which may cause injury to the lung vasculature (the "first event").…”

Section: Introductionmentioning

confidence: 99%

The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study

Vlaar

Hofstra²,

Determann³

et al. 2011

Blood

188

176

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“…1,2 These complications (Table 1) include syndromes suspected to be associated with the conditioning regimen or HCT-related treatment, such as radiation-induced lung injury, [3][4][5][6] drug toxicity, [7][8][9][10] pulmonary veno-occlusive disease (PVOD), [11][12][13] engraftment syndrome, [14][15][16][17] transfusion-related lung injury (TRA-LI), 18,19 idiopathic pneumonia syndrome, [20][21][22][23][24] and diffuse alveolar hemorrhage, [25][26][27][28] as well as syndromes suspected to be a consequence of alloreactive activity, such as chronic airflow obstruction (AFO), [29][30][31][32][33][34][35] bronchiolitis obliterans syndrome (BOS), 33,[36][37][38] and bronchiolitis obliterans organizing pneumonia. [14][15][16][17]39 Although the predictive value of pretransplant pulmonary function testing (PFT) is somewhat controversial, most HCT institutions perform routine pretransplant lung function assessment as a baseline reference, in anticipation of these potential pulmonary toxicities.…”

mentioning

confidence: 99%

Pulmonary function testing prior to hematopoietic stem cell transplantation

Chien

Madtes

Clark

2005

Bone Marrow Transplant

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Summary:The pretransplant pulmonary function test plays an important role in the management of noninfectious pulmonary complications after hematopoietic stem cell transplantation (HCT). Although these tests are widely used as standard preoperative assessments in the nontransplant population, common conditions associated with the HCT patient requires that particular attention be given to interpretation of pulmonary function testing (PFT) results, such as comparison of serial pulmonary function tests and evaluation of the diffusion capacity. Although their utility in helping to predict the likelihood of developing post transplant pulmonary complications and mortality is not well established, current data indicate that pretransplant PFTs are important as a reference for the interpretation of post transplant PFTs and for identifying patients at high risk for developing pulmonary complications and/or mortality after HCT. Future studies of pretransplant pulmonary function should consider the advances in HCT, so that pretransplant PFTs will become a useful tool in pretransplant risk assessment and help the transplant oncologist to determine the most appropriate conditioning regimen for a patient with compromised lung function.

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The association of biologically active lipids with the development of transfusion‐related acute lung injury: a retrospective study

Abstract: TRALI is the result of two clinical events, the first being a predisposing clinical condition and the second being the transfusion of biologically active lipids in stored blood.

Cited by 410 publications

References 20 publications

Pathophysiology of Acute Lung Injury and the Acute Respiratory Distress Syndrome

Pathophysiology of Acute Lung Injury and the Acute Respiratory Distress Syndrome

The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study

Pulmonary function testing prior to hematopoietic stem cell transplantation

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