The association of APOC4 polymorphisms with premature coronary artery disease in a Chinese Han population

Abstract

BackgroundHypercholesterolemia arising from abnormal lipid metabolism is one of the critical risk factors for coronary artery disease (CAD), however the roles of genetic variants in lipid metabolism-related genes on premature CAD (≤60 years old) development still require further investigation. We herein genotyped four single nucleotide polymorphisms (SNPs) in lipid metabolism-related genes (rs1132899 and rs5167 in APOC4, rs1801693 and rs7765781 in LPA), aimed to shed light on the influence of these SNPs on individual susceptibility to early-onset CAD.MethodsGenotyping of the four SNPs (rs1132899, rs5167, rs1801693 and rs7765781) was performed in 224 premature CAD cases and 297 control subjects (≤60 years old) using polymerase chain reaction-ligation detection reaction (PCR–LDR) method. The association of these SNPs with premature CAD was performed with SPSS software.ResultsMultivariate logistic regression analysis showed that C allele (OR = 1.50, P = 0.027) and CC genotype (OR = 2.84, P = 0.022) of APOC4 rs1132899 were associated with increased premature CAD risk, while the other three SNPs had no significant effect. Further stratified analysis uncovered a more evident association with the risk of premature CAD among male subjects (C allele, OR = 1.65, and CC genotype, OR = 3.33).ConclusionsOur data provides the first evidence that APOC4 rs1132899 polymorphism was associated with an increased risk of premature CAD in Chinese subjects, and the association was more significant among male subjects.Electronic supplementary materialThe online version of this article (doi:10.1186/s12944-015-0065-7) contains supplementary material, which is available to authorized users.

CDKN2B‐AS1 gene rs4977574 A/G polymorphism and coronary heart disease: A meta‐analysis of 40,979 subjects

“…The information was drawn out from 18,430 CHD cases and 22,549 controls (Table 1 ). 9 , 10 , 11 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 Of the 35 obtained literatures after the preliminary search course, 17 met the present meta‐analysis including criteria. Among the eighteen eliminated papers, five of them were of review character.…”

Exosome secretome and mediated signaling in breast cancer patients with nontuberculous mycobacterial disease

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Chronic spinal cord changes in a high-fat diet-fed male rat model of thoracic spinal contusion

“…Expression of the human APOC4 in transgenic mice results in increased triglycerides mainly in the very low density lipoprotein species (1). Polymorphisms in APOC4 has links to premature coronary artery disease (36), but upregulation of APOC4 has not specifically been reported in the spinal cord to date. Also in the cholesterol pathway, increases in lecithin-cholesterol acyltransferase (LCAT) was also observed.…”