The association of air pollutants and allergic and nonallergic rhinitis in chronic rhinosinusitis

Mady, Leila J.; Schwarzbach, Hannah L.; Moore, John Bassett; Boudreau, Robert M.; Kaffenberger, Thomas M.; Willson, Thomas D.; Lee, Stella E.

doi:10.1002/alr.22060

Cited by 41 publications

(53 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, as discussed before, no association was found in the study by Annesi-Maesano et al 15 between air pollution levels and score of allergic rhinitis. In the study by Mady et al, 16 a positive correlation was found between exposure to black carbon and some symptoms of rhinitis, regardless of allergic sensitization status, and no results were available for PM 2.5 . Furthermore, this study was based on a small selected sample of patients with disease, without formal statistical analyses.…”

Section: Discussionmentioning

confidence: 89%

“…Recently, an American study examined the relationship between PM 2.5 (airborne particulate matter with an aerodynamic diameter of < _2.5 mm) and black carbon and rhinitis in 125 patients with chronic rhinosinusitis with and without polyps. 16 They found significantly higher exposure levels of PM 2.5 and black carbon among participants without allergic sensitization compared with those with allergic sensitization, and also found an association between black carbon and nonallergic symptoms of rhinitis. In a previous study, we found no consistent evidence for an association between long-term exposure to air pollution and incidence of rhinitis, whether allergic or nonallergic.…”

mentioning

confidence: 94%

See 1 more Smart Citation

Long-term air pollution exposure is associated with increased severity of rhinitis in 2 European cohorts

Burte

Leynaert

Marcon

et al. 2020

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

Background: Very few studies have examined the association between long-term outdoor air pollution and rhinitis severity in adults. Objective: We sought to assess the cross-sectional association between individual long-term exposure to air pollution and severity of rhinitis. Methods: Participants with rhinitis from 2 multicenter European cohorts (Epidemiological Study on the Genetics and Environment on Asthma and the European Community Respiratory Health Survey) were included. Annual exposure to NO 2 , PM 10 , PM 2.5 , and PM coarse (calculated by subtracting PM 2.5 from PM 10) was estimated using land-use regression models derived from the European Study of Cohorts for Air Pollution Effects project, at the participants' residential address. The score of rhinitis severity (range, 0-12), based on intensity of disturbance due to symptoms reported by questionnaire, was categorized into low (reference), mild, moderate, and high severity. Polytomous logistic regression models with a random intercept for city were used. Results: A total of 1408 adults with rhinitis (mean age, 52 years; 46% men, 81% from the European Community Respiratory Health Survey) were included. The median (1st quartile-3rd

show abstract

Section: Discussionmentioning

confidence: 89%

mentioning

confidence: 94%

Long-term air pollution exposure is associated with increased severity of rhinitis in 2 European cohorts

Burte

Leynaert

Marcon

et al. 2020

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

show abstract

“…Several studies have been published on the effects of PM on the upper airway; for example, long-and short-term exposure to PM can lead to allergic rhinitis [24,25]. PM has also been shown to cause non-allergic symptoms in rhinosinusitis patients [26]. In cell experiments, PM exposure was observed to interfere with the barrier function of the epithelial layer by disintegrating the tight junctions of nasal epithelial cells [27].…”

Section: Discussionmentioning

confidence: 99%

Activation of the Nrf2/HO-1 pathway by curcumin inhibits oxidative stress in human nasal fibroblasts exposed to urban particulate matter

Kim

Choi

et al. 2020

BMC Complement Med Ther

View full text Add to dashboard Cite

Background: Particulate matter (PM) can cause various negative acute and chronic diseases of the respiratory system, including the upper airways. Curcumin has been reported to have anti-inflammatory and anti-oxidative effects; therefore, we investigated the effects of curcumin on nasal fibroblasts exposed to urban PM (UPM). Methods: Samples of inferior turbinate tissue were obtained from six patients. Flow cytometry was used to assess the levels of reactive oxygen species (ROS) following the treatment of nasal fibroblasts with UPM and/or curcumin. We evaluated the effects of UPM and/or curcumin on the expression of phosphorylated ERK, Nrf2, HO-1, and SOD2 in fibroblasts by Western blotting. Results: When UPM was applied to nasal fibroblasts, ROS production was significantly increased in a dosedependent manner. UPM-exposed fibroblasts caused the activation of ERK to increase HO-1 expression and decrease SOD2 expression. Treatment with curcumin reduced the UPM-mediated increase in ROS; this decrease in ROS occurred in a dose-dependent manner. The UPM-induced activation of ERK was inhibited by curcumin. Nrf2 production was also promoted to increase the expression of HO-1 and SOD2 by curcumin. Conclusion: Curcumin reduced ROS production caused by UPM in human nasal fibroblasts in a dose-dependent manner, suggesting that curcumin has anti-oxidative effects and may be useful in the treatment of nasal diseases caused by UPM, such as allergic and chronic rhinitis.

show abstract

“…Furthermore, cross-sectional sampling may obscure whether some of the observed differences in subject clusters represent a temporal continuum of specific endotypes as they develop over time. Given the observed inflammatory complexity, together with other potential sources of influence in determining disease subtypes such as genetic ( 34 ) and life history factors ( 35 , 36 ), many more subjects measured over more variables (or more refined variables) and at multiple time points will be necessary to clearly delineate between true endotypes of CRS and to subsequently draw robust conclusions from comparisons.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Endotypes and Microbial Associations in Chronic Rhinosinusitis

et al. 2018

View full text Add to dashboard Cite

A complex mix of inflammatory and microbial associations underscores the chronic inflammatory condition chronic rhinosinusitis (CRS), and the etiology remains poorly understood. Recent work has begun to delineate between variants (endotypes) of CRS on the basis of inflammatory biomarkers. This study aimed to assess inflammatory patterns in CRS phenotypes, identify putative endotypes of CRS, and to assess inflammatory associations with the sinonasal microbiota. Ten cytokines and six inflammatory cell types were assessed in mucosal biopsies from 93 CRS subjects and 17 controls via cytometric bead array and immunohistochemical techniques. Putative endotypes were identified via cluster analysis of subjects on the basis of inflammatory markers and comorbidities including polyposis, asthma, and aspirin sensitivity. Finally, previously published bacterial data for this cohort were reanalyzed to evaluate associations with inflammatory markers and CRS subtypes. Inflammatory patterns were highly variable within standard CRS phenotypes. Cluster analysis identified eight subject clusters, with strong delineation on the basis of polyposis and asthma, but also subtle distinctions in inflammatory markers. An association was also identified between depletion of several “health-associated” bacterial taxa, reduced bacterial diversity and increased overall bacterial load, with markers of inflammation and clinical severity. This study contributes to ongoing efforts to define distinct endotypes of CRS on the basis of underlying inflammatory processes, and also offers compelling evidence of a link between bacterial community dysbiosis and inflammation in CRS. Further resolving the heterogeneity of CRS is vital to inform clinical management and personalized treatment approaches.

show abstract

The association of air pollutants and allergic and nonallergic rhinitis in chronic rhinosinusitis

Abstract: Our results suggest that small inhalant pollutants may contribute to nonallergic symptomatology in patients with and without nasal polyps. Regardless of allergy status, BC may play a role in CRS symptom severity.

Cited by 41 publications

References 36 publications

Long-term air pollution exposure is associated with increased severity of rhinitis in 2 European cohorts

Long-term air pollution exposure is associated with increased severity of rhinitis in 2 European cohorts

Activation of the Nrf2/HO-1 pathway by curcumin inhibits oxidative stress in human nasal fibroblasts exposed to urban particulate matter

Inflammatory Endotypes and Microbial Associations in Chronic Rhinosinusitis

Contact Info

Product

Resources

About