The association of age and semen quality in healthy men

Eskenazi, Brenda; Wyrobek, Andrew J.; Sloter, Eddie D.; Kidd, Sharon A.; Moore, L.A.; Young, Suzanne; Moore, Dan H.

doi:10.1093/humrep/deg107

Cited by 331 publications

(261 citation statements)

References 47 publications

(74 reference statements)

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“…We also demonstrated here the decrease in other sperm parameters such as volume, concentration and motility. This reduction of sperm parameters by male age is well established and described [27][28][29][30].…”

Section: Discussionmentioning

confidence: 87%

Male age influences oocyte-donor program results

Girsh

Katz

Genkin

et al. 2008

J Assist Reprod Genet

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Background The purpose of our research was to examine the relationship between male age and semen parameters in a range of ages (from 20s to 60s) in Egg Donation Program (EDP) cycles. EDP provides a pool of high quality oocytes, thus allowing better analysis of the sperm efficacy. Discussion The retrospective study population consisted of 484 male partners of patients undergoing EDP in in-vitro fertilization (IVF) treatments. A comparison was made of male age and sperm parameters within two groups: cycles resulting in a pregnancy (pregnant group) and cycles which failed to achieve a pregnancy (non-pregnant group). The men involved in the pregnant group were found to be significantly younger 43.2±8.1 than those of the nonpregnant group 46.8±7.8 (p=0.003). Analysis of sperm morphology revealed a significant prevalence of teratozoospermia in males of the non-pregnant group, as compared to the males of the pregnant group (29% vs. 11%, respectively). The results also demonstrate that sperm parameters are apparently not diminished until men reach the age of 40. However, between 40-50 years old semen parameters deteriorate. Male age was found to be related to a reduction in sperm strict criteria: 44.8 in normozoospermia, 47.9 (p=0.02), 48.4 (p=0.04) and 51.9 (p=0.001) years old in mild teratozoospermia, moderate teratozoospermia and severe teratozoospermia, respectively. Additionally, the results showed that the percentage of "healthy" embryos on day 3 of embryo culture was lower in the non-pregnant group (26%), as compared with the pregnant group (34%; p=0.01). Conclusion Our study confirms that sperm parameters are reduced by age and suggests that this age-dependent effect could be a reason for failures in IVF cycles even in EDP couples.

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Section: Discussionmentioning

confidence: 87%

Male age influences oocyte-donor program results

Girsh

Katz

Genkin

et al. 2008

J Assist Reprod Genet

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“…Abstinence adjusted studies do not provide a uniform picture. A significant age-dependent decrease [2,25] as well as constant values over the age range [19] or even a non significant age dependent increase with age [26] have been detected in healthy men. In infertile patient's sperm concentration remains unalterated [22] or increases [21,23,[26][27][28][29].…”

Section: Discussionmentioning

confidence: 98%

“…For total sperm count we show that it did not significantly differ with age group of fertile and infertile men. Few studies have analyzed the total sperm count and this decreases with age in fertile men [2] but remains constant in infertile men [21]. Age may not only impact semen quality, but also the genetic integrity of the sperm.…”

Section: Discussionmentioning

confidence: 99%

“…Among the basic semen parameters studied, semen volume, percentage of motile spermatozoa, and the percentage of normal morphology were more consistently reported to decrease with age. However, no consistent data confirm that sperm concentration also decline with advancing years [1,2]. Semen analysis provides limited prognostic information on fertility, and recent studies indicated that the integrity of sperm DNA might be a more accurate and precise predictor of fertility [3] an intact DNA is necessary for the correct transmission of genetic materiel to the next generation.…”

Section: Introductionmentioning

confidence: 99%

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The effects of male aging on semen quality, sperm DNA fragmentation and chromosomal abnormalities in an infertile population

Brahem

Mehdi

Elghezal

et al. 2011

J Assist Reprod Genet

107

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Purpose To investigate the effects of male aging on semen quality, DNA fragmentation and chromosomal abnormalities in the spermatozoa of infertile patients and fertile men. Methods Semen samples of 140 infertile patients (24-76 years) and 50 men with proven fertility (25-65 years) were analyzed according to WHO guidelines. DNA fragmentation was detected by TUNEL assay, while aneuploidy was assessed by FISH. Results In the patient group, semen volume and vitality of spermatozoa decreased significantly with age, while sperm concentration showed a statistically significant increase with age. DNA fragmentation as well as disomy of sex chromosomes and disomy 8 did not show a statistically significant change with age. However, the diploidy rate was significantly increased with patient's age. In the control group, conventional semen parameters as well as DNA fragmentation and chromosomal abnormalities did not show a statistically significant with age. Conclusion Increased age in infertile men is associated with an increase in sperm concentration and diploidy, as well as a decline in semen volume and sperm vitality. However motility, morphology and DNA fragmentation are not affected by male age.

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“…Male gonad evaluation requires a complete urologic examination in order to determine semen alterations due to increasing age (3,4), genital system abnormalities (e.g., varicocele, orchitis, testicular cancer, mumps) (5), influence of drugs (particularly intravenous cyclophosphamide [IV CYC]) (6)(7)(8)(9), and antisperm antibodies (10). There is, however, no systematic study in the literature assessing the overall gonad function in male SLE patients and its relevance for sperm abnormalities.…”

Section: Objective To Assess Gonad Function In Male Patients With Symentioning

confidence: 99%

Gonad evaluation in male systemic lupus erythematosus

Soares¹,

Borba²,

Bonfá³

et al. 2007

Arthritis & Rheumatism

103

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Objective. To assess gonad function in male patients with systemic lupus erythematosus (SLE).Methods. Thirty-five consecutive male patients with SLE according to the criteria of the American College of Rheumatology were prospectively evaluated for demographic and clinical features as well as previous and current treatment. Patients underwent urologic evaluation and testicular Doppler ultrasound. We obtained a hormone profile and performed a semen analysis including morphology and testing for the presence of antisperm antibodies. Patients were compared with 35 age-matched healthy controls.Results. Compared with controls, SLE patients had lower median testicular volumes in both testes, a lower median total sperm count, and a lower median total motile sperm count. The mean sperm volume and percentage of normally formed sperm were lower in SLE patients than in controls. Since all SLE patients had semen alterations, they were further subdivided into 2 groups according to the severity of these abnormalities (group 1, with teratozoospermia [n ‫؍‬ 18], and group 2, with azoospermia or teratozoospermia in combination with oligozoospermia and/or asthenozoospermia [n ‫؍‬ 17]). The frequency of treatment with intravenous cyclophosphamide (IV CYC) after the first ejaculation was higher in group 2 than in group 1. The median testicular volumes measured by ultrasound in both testicles were lower in group 2 than in group 1. Follicle-stimulating hormone levels were higher in group 2 than in group 1. The overall frequency of antisperm antibodies in SLE patients was 40%. The apparent higher frequency of antisperm antibodies in group 1 than in group 2 did not reach significance.Conclusion. SLE patients have a high frequency of sperm abnormalities associated with reduced testicular volume. Postpubertal IV CYC treatment was the major factor in potential permanent damage to the testes.

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The association of age and semen quality in healthy men

Abstract: In a convenience sample of healthy men from a non-clinical setting, semen volume and sperm motility decreased continuously between 22-80 years of age, with no evidence of a threshold.

Cited by 331 publications

References 47 publications

Male age influences oocyte-donor program results

Male age influences oocyte-donor program results

The effects of male aging on semen quality, sperm DNA fragmentation and chromosomal abnormalities in an infertile population

Gonad evaluation in male systemic lupus erythematosus

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