The Association of Acute Phase Proteins in Stress and Inflammation-Induced T2D

Speelman, Tammy; Dale, Lieke; Louw, Ann; Verhoog, Nicolette

doi:10.3390/cells11142163

Cited by 14 publications

(9 citation statements)

References 217 publications

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“…In addition, acute pancreatitis generates a robust local and systemic in ammatory response (even in clinically mild episodes), which can produce a continuous irritation of the pancreas. This chronic in ammation can lead to insulin resistance on the one hand and damage to pancreatic tissue on the other hand 41 .…”

Section: Discussionmentioning

confidence: 99%

Impact of stress hyperglycemia on long-term prognosis in acute pancreatitis without diabetes

Zhang,

Wang,

et al. 2024

Intern Emerg Med

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BackgroundStress hyperglycemia has been con rmed as a strong predictor of poor short-term prognosis in acute pancreatitis. However, whether stress hyperglycemia affects the long-term prognosis of patients with acute pancreatitis is unclear. We aimed to investigate the effect of stress hyperglycemia on the long-term prognosis of non-diabetic patients with acute pancreatitis. MethodsThis retrospective observational study was conducted on 4055 patients with acute pancreatitis from 1 January 2016 to 31 October 2020. The association between Stress hyperglycemia and the prognosis was evaluated using regression modeling. ResultsThere were 935(71.5%) normoglycemic and 373(28.5%) Stress hyperglycemia patients. 46(12.3%) patients with Stress hyperglycemia had evidence of diabetes compared with 33(3.5%) patients without stress hyperglycemia (P < 0.001). After multivariate adjustment, patients with Stress hyperglycemia were more likely to have evidence of diabetes (OR 2.905, 95% CI 1.688-4.999) compared with normoglycemic.However, Stress hyperglycemia is not associated with the recurrence of pancreatitis and progression to chronic pancreatitis. ConclusionsStress hyperglycemia was independently associated with diabetes secondary to acute pancreatitis. Accordingly, a follow-up diabetes-screening program for AP with stress hyperglycemia is an important part of identifying the disease as soon as possible, delaying islet damage, and improving the prognosis of post-acute pancreatitis diabetes mellitus.

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Section: Discussionmentioning

confidence: 99%

Impact of stress hyperglycemia on long-term prognosis in acute pancreatitis without diabetes

Zhang,

Wang,

et al. 2024

Intern Emerg Med

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“…Phenylalanine and tryptophan belong to aromatic amino acids, which can synthesize acute proteins in response to inflammation [ 50 ]. Such proteins can play an anti-inflammatory effect through immune regulation [ 51 ]. Therefore, the disturbance of aromatic amino acid metabolism in WTI rats may be related to the immune response of RILI.…”

Section: Discussionmentioning

confidence: 99%

Metabolomic Signatures Associated with Radiation-Induced Lung Injury by Correlating Lung Tissue to Plasma in a Rat Model

Gu,

Wang,

et al. 2023

Metabolites

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The lung has raised significant concerns because of its radiosensitivity. Radiation-induced lung injury (RILI) has a serious impact on the quality of patients’ lives and limits the effect of radiotherapy on chest tumors. In clinical practice, effective drug intervention for RILI remains to be fully elucidated. Therefore, an in-depth understanding of the biological characteristics is essential to reveal the mechanisms underlying the complex biological processes and discover novel therapeutic targets in RILI. In this study, Wistar rats received 0, 10, 20 or 35 Gy whole-thorax irradiation (WTI). Lung and plasma samples were collected within 5 days post-irradiation. Then, these samples were processed using liquid chromatography–mass spectrometry (LC-MS). A panel of potential plasma metabolic markers was selected by correlation analysis between the lung tissue and plasma metabolic features, followed by the evaluation of radiation injury levels within 5 days following whole-thorax irradiation (WTI). In addition, the multiple metabolic dysregulations primarily involved amino acids, bile acids and lipid and fatty acid β-oxidation-related metabolites, implying disturbances in the urea cycle, intestinal flora metabolism and mitochondrial dysfunction. In particular, the accumulation of long-chain acylcarnitines (ACs) was observed as early as 2 d post-WTI by dynamic plasma metabolic data analysis. Our findings indicate that plasma metabolic markers have the potential for RILI assessment. These results reveal metabolic characteristics following WTI and provide new insights into therapeutic interventions for RILI.

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“…Chronic low-grade inflammation is commonly associated with T2D and is thought to cause many of the clinical manifestations associated with the secondary complications of T2D [ 37 ]. Many of these complications are associated with increased oxidative stress and the apoptosis of islet β-cells [ 38 ].…”

Section: Molecular and Cellular Basis Of T2d Pathogenesismentioning

confidence: 99%

The Perfect Cup? Coffee-Derived Polyphenols and Their Roles in Mitigating Factors Affecting Type 2 Diabetes Pathogenesis

Chapple,

Woodfin,

Moore

2024

Molecules

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Type 2 diabetes (T2D) is a growing health concern with an estimated 462 million people having been diagnosed worldwide. T2D is characterized by chronically elevated blood glucose and insulin resistance, which culminate in a diminished function of the β-cell mass in its later stages. This can be perpetuated by and result in inflammation, excess reactive oxygen species production, obesity, and the dysregulation of multiple cellular pathways. Many naturally occurring small molecules have been investigated in terms of their roles in modulating glucose homeostasis and β-cell function. Many of these compounds can be found in commonly used sources of food and drink. Interestingly, a correlation has been observed between coffee consumption and T2D incidence. However, the specific compounds responsible for this correlation and their mechanisms are still somewhat undetermined. This paper reviews recent research findings on the effects of several polyphenols that are either found in coffee or are metabolites of compounds found in coffee (enterodiol, enterolactone, matairesinol, secoisolariciresinol, kaempferol, quercetin, and chlorogenic acid) on glucose homeostasis and health complications associated with glucose dysregulation, with a special emphasis on their potential anti-diabetic effects. The factors that affect polyphenol content in coffee are also addressed.

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The Association of Acute Phase Proteins in Stress and Inflammation-Induced T2D

Cited by 14 publications

References 217 publications

Impact of stress hyperglycemia on long-term prognosis in acute pancreatitis without diabetes

Impact of stress hyperglycemia on long-term prognosis in acute pancreatitis without diabetes

Metabolomic Signatures Associated with Radiation-Induced Lung Injury by Correlating Lung Tissue to Plasma in a Rat Model

The Perfect Cup? Coffee-Derived Polyphenols and Their Roles in Mitigating Factors Affecting Type 2 Diabetes Pathogenesis

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