The association of ABO blood group with incidence and outcome of acute pulmonary embolism

Hajizadeh, Reza; Kavandi, Hadiseh; Nadiri, Mehdi; Ghaffari, Samad

doi:10.5543/tkda.2016.43996

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…5 ), consistent with previous studies 34 . We were also able to replicate SNPs associated with all four lipid traits and Alzheimer’s disease, mapping to the known APOE and TOMM40 genes on chromosome 19, as well as pulmonary embolism, mapping to the previously known ABO gene on chromosome 9 35 , 36 . For both pulmonary embolism and Alzheimer’s disease, direction of effect was largely consistent between lipids and disease (concordant).…”

Section: Resultsmentioning

confidence: 80%

A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts

et al. 2021

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Plasma lipids are known heritable risk factors for cardiovascular disease, but increasing evidence also supports shared genetics with diseases of other organ systems. We devised a comprehensive three-phase framework to identify novel lipid-associated genes and study the relationships between lipids, genotypes, gene expression and hundreds of complex human diseases from electronic Medical Records and Genomics (347 traits) and UK Biobank (549 traits) cohorts. Aside from 67 novel lipid-associated genes with strong replication, we found evidence for pleiotropic SNPs/genes between lipids and diseases across the phenome. These include discordant pleiotropy in the HLA region between lipids and multiple sclerosis and putative causal paths between triglycerides and gout, among several others. Our findings give insights into the genetic basis of the relationship between plasma lipids and diseases on a phenome-wide scale and can provide context for future prevention and treatment strategies.

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Section: Resultsmentioning

confidence: 80%

A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts

et al. 2021

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“…A number of epidemiologic studies carried out over the past 20 years have made the observation of an apparent association between ABO blood group and the prevalence of many thromboembolic diseases , including venous thromboembolic events (VTE) , cerebrovascular ischaemic events , including recurrent stroke , coronary artery disease , myocardial infarction (MI) and atherosclerotic vascular disease . In general, these studies have found that individuals with non‐group O phenotypes are at increased risk for thromboembolic diseases compared to those who are group O.…”

Section: A Tripod – Abo Histo‐blood Groups Von Willebrand's Factor Amentioning

confidence: 99%

Biologic roles of the ABH and Lewis histo‐blood group antigens part II: thrombosis, cardiovascular disease and metabolism

Stowell

2019

Vox Sanguinis

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The ABH and Lewis antigens were among the first of the human red blood cell polymorphisms to be identified and, in the case of the former, play a dominant role in transfusion and transplantation. But these two therapies are largely twentieth‐century innovations, and the ABH and related carbohydrate antigens are not only expressed on a very wide range of human tissues, but were present in primates long before modern humans evolved. Although we have learned a great deal about the biochemistry and genetics of these structures, the biological roles that they play in human health and disease are incompletely understood. This review and its companion, which appeared in a previous issue of Vox Sanguinis, will focus on a few of the biologic and pathologic processes which appear to be affected by histo‐blood group phenotype. The first of the two reviews explored the interactions of two bacteria with the ABH and Lewis glycoconjugates of their human host cells, and described the possible connections between the immune response of the human host to infection and the development of the AB‐isoagglutinins. This second review will describe the relationship between ABO phenotype and thromboembolic disease, cardiovascular disease states, and general metabolism.

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“…PMR often causes mitral regurgitation (MR) and present in < 1% of AMI patients who undergo early revascularization according to recent data [ 9 ]. Several previous studies have verified the association between blood group A and the increased risk of vascular diseases including coronary artery disease (CAD) [ 10 – 15 ]. Non-O blood groups were also determined to be a significant prognostic indicator of poor prognosis in AMI patients [ 16 – 18 ].…”

Section: Introductionmentioning

confidence: 99%

Blood group A: a risk factor for heart rupture after acute myocardial infarction

Chen

Sun

et al. 2020

BMC Cardiovasc Disord

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Introduction Studies have been performed to identify the association between ABO blood groups and coronary artery disease. However, data is scarce about the impact of ABO blood groups on heart rupture (HR) after acute myocardial infarction (AMI). Methods We conducted a retrospective case–control study that included 61 consecutive patients with HR after AMI during a period from 1 January 2012 to 1 December 2019. The controls included 600 patients who were selected randomly from 8143 AMI patients without HR in a ratio of 1:10. Univariate and multivariate logistic regression analysis were used to identify the association between ABO blood groups and HR. Results Patients with blood group A had a greater risk of HR after AMI than those with non-A blood groups (12.35% vs 7.42%, P < 0.001). After adjusting for age, gender, heart rate at admission, body mass index (BMI), and systolic blood pressure (SBP), blood group A was independently related to the increased risk of HR after AMI (OR = 2.781, 95% CI 1.174–7.198, P = 0.035), and remained as an independent risk factor of HR after AMI in different multivariate regression models. Conclusion Blood group A is significantly associated with increased HR risk after AMI.

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The association of ABO blood group with incidence and outcome of acute pulmonary embolism

Abstract: Blood group A was significantly more common, and blood group 0 significantly less common, in patients with PE. No association was found regarding blood type and in-hospital outcome or midterm mortality.

Cited by 5 publications

References 27 publications

A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts

A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts

Biologic roles of the ABH and Lewis histo‐blood group antigens part II: thrombosis, cardiovascular disease and metabolism

Blood group A: a risk factor for heart rupture after acute myocardial infarction

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