The association of a nucleobindin 2 gene (NUCB2) variant with childhood adiposity

Chen, Yan Yan; Chan, Raymond Ming En; Tan, Karen; Poh, Larry Kok Seng; Loke, Kah Yin; Wang, Jin Ping; Li, Hui; Hu, Ying; Wang, Lin; Lee, Kok-Onn; Li, Guang Wei; Lee, Yung Seng

doi:10.1016/j.gene.2012.12.017

Cited by 13 publications

(15 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…et al [39] has independently demonstrated the association of this allele with adiposity in childhood, providing further support for the role of NUCB2 and its genetic variant in the determination of human adiposity. These results showed that the NUCB2 variant c.1012C>G (Q338E) was associated with childhood adiposity.…”

Section: Polymorphisms In the Nucb2/nesfatin-1 Genementioning

confidence: 81%

Recent progress in research on the distribution and function of NUCB2/Nesfatin-1 in peripheral tissues [Review]

2013

View full text Add to dashboard Cite

Abstract. Nesfatin-1 is a polypeptide derived from the posttranslational processing of the N-terminal fragment of nucleobindin 2 (NUCB2), that was originally identified as an anorexigenic hypothalamic neuropeptide. A number of reports have recently shown that NUCB2/Nesfatin-1 is widely expressed in various peripheral tissues, including those of the gastrointestinal tract where it may participate in various pathophysiological processes. One of its roles may be regulation of energy homeostasis. As a result, Nesfatin-1 may be a novel target for exploring the underlying mechanisms and the treatment of metabolic syndromes.Key words: Nesfatin-1, Peripheral tissues, Satiety factor, Metabolic syndrome Along with the improvement in living standards, obesity-related metabolic syndrome, whose incidence is rapidly growing every year, negatively affects people's health and life. It was well known that obesity arose from an imbalance between energy intake and expenditure; however, certain mechanisms involved in this process were still unknown. In 2006 Oh I et al. [1] found that an intracerebroventricular injection of recombinant nucleobindin 2(NUCB2), later termed NUCB2-encoded satiety-and fat-influencing protein or Nesfatin, reduced nocturnal feeding and body weight gain. Subsequent studies found that intraperitoneal injection of Nesfatin-1 also suppressed food intake and decreased body weight gain [2]. These observations suggested that Nesfatin-1 played an important role in the regulation of body energy balance. It had been found that plasma Nesfatin-1 crossed the bloodbrain barrier without saturation [3], and either peripheral or central administration of Nesfatin-1 reduced food intake through a leptin-independent mechanism [4]. Therefore, research on the distribution and function of Nesfatin-1 in peripheral tissue were important. Herein, we provided a brief review of the current knowledge regarding Nesfatin-1 distribution and function in peripheral tissues. genomics and protein structure of nUCB2/nesfatin-1NUCB2 was originally identified as a hypothalamus secreted protein that was found in hypothalamic nuclei involved in feeding regulation. Furthermore, NUCB2 was composed of a signal peptide containing 24 amino acids and a protein structure containing 396 amino acids [5]. Its gene was located on the 11q151, and the aminoacid sequence of NUCB2 was highly conserved in rats (95% homology) and mice (87.4% homology) [6].Posttranslational processing of NUCB2 by prohormone convertase produces 3 cleavage products, namely Nesfatin-1 (1-82), . Nesfatin-1 is an 82-amino-acid peptide derived from posttranslational processing of the N-terminal fragment of NUCB2 and has a predicted molecular mass of 9.8 kDa. A study by Oh I et al. indicated that of the 3 cleavage products, only Nesfatin-1 can decrease food intake and body weight [1]. Furthermore, structural and functional analyses showed that after intraperitoneal and intracerebroventricular injection of the 3 segments of Nesfatin-1, the N-terminal segment, the C-terminal segment, or t...

show abstract

Section: Polymorphisms In the Nucb2/nesfatin-1 Genementioning

confidence: 81%

Recent progress in research on the distribution and function of NUCB2/Nesfatin-1 in peripheral tissues [Review]

2013

View full text Add to dashboard Cite

show abstract

“…Recently, the c.1012C>G polymorphism of NUCB2 gene was found to be correlated with obesity [7, 8]. Obesity is a risk factor of developing T2DM.…”

Section: Discussionmentioning

confidence: 99%

“…Chen et al then reported that one SNP of NUCB2 gene, c.1012C>G (Q338E or rs757081) was correlated with childhood adiposity [8]. These data indicate that polymorphisms in the NUCB2 gene could play an important role in the protection against the development of obesity.…”

Section: Introductionmentioning

confidence: 99%

Association of the polymorphism in NUCB2 gene and the risk of type 2 diabetes

Wang

2017

Diabetol Metab Syndr

View full text Add to dashboard Cite

BackgroundNesfatin-1, originating from its precursor protein called nucleobindin 2 (NUCB2), plays an important role in glucose metabolism and diabetes. The aim of this study is to examine the association of the c.1012C>G (rs757081) polymorphism of NUCB2 gene with the presence of T2DM.MethodsThis study was performed in a population of 396 patients with T2DM and 196 healthy subjects. The c.1012C>G polymorphism of NUCB2 gene was determined using polymerase chain reaction and sequencing method.ResultsT2DM patients showed lower CG and GG genotype, as well as G allele frequencies compared with healthy subjects. Logistic regression analysis showed that c.1012C>G polymorphism was associated with a decreased risk of developing T2DM. In addition, GG genotype of NUCB2 was significantly correlated with lower levels of body mass index and fasting plasma glucose in patients with T2DM.ConclusionsThe c.1012C>G polymorphism of NUCB2 is associated with the decreased risk of developing T2DM in Chinese Han population.

show abstract

“…Specifically, the 1012C > G polymorphism reduces the susceptibility for the development of an obese phenotype. The GG genotype is more frequent in healthy, lean individuals than in obese children (Chen et al 2013) and patients suffering from the metabolic syndrome (Wang et al 2016), and its presence in the latter patients is associated with lower fasting glucose levels (Wang et al 2016). These findings in metabolic syndrome patients are complemented by the negative association of this polymorphism with blood pressure (Tragante et al 2014).…”

Section: Geneticsmentioning

confidence: 99%

Nesfatin-1: functions and physiology of a novel regulatory peptide

Dore

Levata

Lehnert

et al. 2017

Journal of Endocrinology

110

View full text Add to dashboard Cite

Nesfatin-1 was identified in 2006 as a potent anorexigenic peptide involved in the regulation of homeostatic feeding. It is processed from the precursor-peptide NEFA/ nucleobindin 2 (NUCB2), which is expressed both in the central nervous system as well as in the periphery, from where it can access the brain via non-saturable transmembrane diffusion. In hypothalamus and brainstem, nesfatin-1 recruits the oxytocin, the melancortin and other systems to relay its anorexigenic properties. NUCB2/nesfatin-1 peptide expression in reward-related areas suggests that nesfatin-1 might also be involved in hedonic feeding. Besides its initially discovered anorexigenic properties, over the last years, other important functions of nesfatin-1 have been discovered, many of them related to energy homeostasis, e.g. energy expenditure and glucose homeostasis. Nesfatin-1 is not only affecting these physiological processes but also the alterations of the metabolic state (e.g. fat mass, glycemic state) have an impact on the synthesis and release of NUCB2 and/or nesfatin-1. Furthermore, nesfatin-1 exerts pleiotropic actions at the level of cardiovascular and digestive systems, as well as plays a role in stress response, behavior, sleep and reproduction. Despite the recent advances in nesfatin-1 research, a putative receptor has not been identified and furthermore potentially distinct functions of nesfatin-1 and its precursor NUCB2 have not been dissected yet. To tackle these open questions will be the major objectives of future research to broaden our knowledge on NUCB2/nesfatin-1.

show abstract

The association of a nucleobindin 2 gene (NUCB2) variant with childhood adiposity

Cited by 13 publications

References 15 publications

Recent progress in research on the distribution and function of NUCB2/Nesfatin-1 in peripheral tissues [Review]

Recent progress in research on the distribution and function of NUCB2/Nesfatin-1 in peripheral tissues [Review]

Association of the polymorphism in NUCB2 gene and the risk of type 2 diabetes

Nesfatin-1: functions and physiology of a novel regulatory peptide

Contact Info

Product

Resources

About