The association between vitamin D status and inflammatory bowel disease among children and adolescents: A systematic review and meta-analysis

Fatahi, Somaye; Alyahyawi, Naseem; Albadawi, Naryman; Mardali, Farzaneh; Dara, Naghi; Sohouli, Mohammad Hassan; Prabahar, Kousalya; Rohani, Pejman; Koushki, Nazanin; Sayyari, Aliakbar; Hosseini, Ahmad; Abu‐Zaid, Ahmed

doi:10.3389/fnut.2022.1007725

Cited by 7 publications

(5 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…show that patients with IBD and especially CD also show a low vitamin D status and indicate a correlation with disease activity. Unfortunately, disentangling causality and correlation is an unresolved challenge in the ongoing debate about the interplay between Vitamin D and IBD [36][37][38].…”

Section: Discussionmentioning

confidence: 99%

Correlation of Socioeconomic and Environmental Factors With Incidence of Crohn Disease in Children and Adolescents: Systematic Review and Meta-Regression

Weidner,

Glauche,

Manuwald

et al. 2024

JMIR Public Health Surveill

View full text Add to dashboard Cite

Background The worldwide incidence of Crohn disease (CD) in childhood and adolescence has an increasing trend, with significant differences between different geographic regions and individual countries. This includes an increase in the incidence of CD in countries and geographic regions where CD was not previously prevalent. In response to the increasing incidence, the pediatric care landscape is facing growing challenges. Objective This systematic review and meta-analysis were undertaken to comprehensively delineate the incidence rates of CD in pediatric populations across different countries and to explore potential influencing factors. Methods We performed a systematic review of PubMed and Embase (via Ovid) for studies from January 1, 1970, to December 31, 2019. In addition, a manual search was performed in relevant and previously published reviews. The results were evaluated quantitatively. For this purpose, random effects meta-analyses and meta-regressions were performed to investigate the overall incidence rate and possible factors influencing the incidence. Results A qualitative synthesis of 74 studies was performed, with 72 studies included in the meta-analyses and 52 in the meta-regressions. The results of our meta-analysis showed significant heterogeneity between the individual studies, which cannot be explained by a sample effect alone. Our findings showed geographical differences in incidence rates, which increased with increasing distance from the equator, although no global temporal trend was apparent. The meta-regression analysis also identified geographic location, UV index, and Human Development Index as significant moderators associated with CD incidence. Conclusions Our results suggest that pediatric CD incidence has increased in many countries since 1970 but varies widely with geographic location, which may pose challenges to the respective health care systems. We identified geographic, environmental, and socioeconomic factors that contribute to the observed heterogeneity in incidence rates. These results can serve as a basis for future research. To this end, implementations of internationally standardized and interoperable registries combined with the dissemination of health data through federated networks based on a common data model, such as the Observational Medical Outcomes Partnership, would be beneficial. This would deepen the understanding of CD and promote evidence-based approaches to preventive and interventional strategies as well as inform public health policies aimed at addressing the increasing burden of CD in children and adolescents. Trial Registration PROSPERO International prospective register of systematic reviews CRD42020168644; https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=168644 International Registered Report Identifier (IRRID) RR2-10.1136/bmjopen-2020-037669

show abstract

Section: Discussionmentioning

confidence: 99%

Correlation of Socioeconomic and Environmental Factors With Incidence of Crohn Disease in Children and Adolescents: Systematic Review and Meta-Regression

Weidner,

Glauche,

Manuwald

et al. 2024

JMIR Public Health Surveill

View full text Add to dashboard Cite

show abstract

“…Suboptimal concentrations of vitamin D negatively affect the epithelial barrier and immune functions and lead to increased dysbiosis and possible translocation of intestinal bacteria, thereby influencing the onset and progression of IBD [ 9 , 10 ]. Vitamin D deficiency is common in IBD patients [ 10 , 11 ], but some studies also reported a lack of decrease in vitamin D levels in these patients [ 12 , 13 ]. There are also different results in children with IBD pointing to an association between IBD severity, activity, therapeutic control and vitamin D levels [ 11 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…Vitamin D deficiency is common in IBD patients [ 10 , 11 ], but some studies also reported a lack of decrease in vitamin D levels in these patients [ 12 , 13 ]. There are also different results in children with IBD pointing to an association between IBD severity, activity, therapeutic control and vitamin D levels [ 11 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

Association of selected adipokines with vitamin D deficiency in children with inflammatory bowel disease

Geryk,

Kucerova,

Velganova-Veghova

et al. 2024

BMC Pediatr

View full text Add to dashboard Cite

Background Adipose tissue is significantly involved in inflammatory bowel disease (IBD). Vitamin D can affect both adipogenesis and inflammation. The aim of this study was to compare the production of selected adipokines, potentially involved in the pathogenesis of IBD - adiponectin, resistin, retinol binding protein 4 (RBP-4), adipocyte fatty acid binding protein and nesfatin-1 in children with IBD according to the presence of 25-hydroxyvitamin D (25(OH)D) deficiency. Methods The study was conducted as a case-control study in pediatric patients with IBD and healthy children of the same sex and age. In addition to adipokines and 25(OH)D, anthropometric parameters, markers of inflammation and disease activity were assessed in all participants. Results Children with IBD had significantly higher resistin levels regardless of 25(OH)D levels. IBD patients with 25(OH)D deficiency only had significantly lower RBP-4 compared to healthy controls and also compared to IBD patients without 25(OH)D deficiency. No other significant differences in adipokines were found in children with IBD with or without 25(OH)D deficiency. 25(OH)D levels in IBD patients corelated with RBP-4 only, and did not correlate with other adipokines. Conclusions Whether the lower RBP-4 levels in the 25(OH)D-deficient group of IBD patients directly reflect vitamin D deficiency remains uncertain. The production of other adipokines does not appear to be directly related to vitamin D deficiency.

show abstract

“…In the field of IBD research, it was found that vitamin D deficiency was associated with IBD ( 7 ). Vitamin D is a lipophilic compound synthesized in the skin under the sun, and it is hydroxylated to 25-hydroxyvitamin D [25(OH)D] in the liver and further hydroxylated in the kidneys to 1,25-dihydroxyvitamin D [1,25(OH)2D], which is the active metabolite ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Association between vitamin D level and pediatric inflammatory bowel disease: A systematic review and meta-analysis

et al. 2023

View full text Add to dashboard Cite

BackgroundPrevious studies have reported that the incidence of pediatric inflammatory bowel disease (IBD) is related to vitamin D, but it is still unclear. This study intends to calculate the relationship between pediatric IBD and vitamin D.MethodsA comprehensive literature search from inception to January 2023 was performed in the PubMed, EMBASE, Medline, Web of Science, and Google Scholar databases. Relevant data were extracted as required and used for subsequent calculations.ResultsSixteen papers were included, and there was no significant difference between the average vitamin D level in IBD patients and healthy controls. In addition, the overall pooled results showed that C-reactive protein (CRP) was 2.65 higher before vitamin D supplementation than after supplementation [SMD = 2.65, 95% CI = (2.26, 3.04)]. Moreover, patients with IBD in remission were 0.72 higher before vitamin D supplementation than after supplementation [OR = 0.72, 95% CI = (0.52, 1.00)].ConclusionThis study suggested that there was no obvious relationship between pediatric IBD and vitamin D, while vitamin D supplementation can improve disease activity. Therefore, follow-up still needs many prospective studies to confirm the relationship between pediatric IBD and vitamin D.

show abstract

The association between vitamin D status and inflammatory bowel disease among children and adolescents: A systematic review and meta-analysis

Cited by 7 publications

References 55 publications

Correlation of Socioeconomic and Environmental Factors With Incidence of Crohn Disease in Children and Adolescents: Systematic Review and Meta-Regression

Correlation of Socioeconomic and Environmental Factors With Incidence of Crohn Disease in Children and Adolescents: Systematic Review and Meta-Regression

Association of selected adipokines with vitamin D deficiency in children with inflammatory bowel disease

Association between vitamin D level and pediatric inflammatory bowel disease: A systematic review and meta-analysis

Contact Info

Product

Resources

About