The association between vitamin D receptor polymorphisms and serum 25-hydroxyvitamin D levels with ulcerative colitis in Chinese Han population

Vitamin D receptor FokI polymorphism and the risks of colorectal cancer, inflammatory bowel disease, and colorectal adenoma

“…Therefore, we identified a total of 26 articles on the association between VDR Fok I polymorphism and colorectal diseases and included the results from the current case-control study. Finally, 27 studies investigating various colorectal diseases were included in this meta-analysis: colorectal cancer (16 studies; 10,257 cases/12,492 controls) 11 , 12 , 18 – 30 , colorectal adenoma (4 studies; 1,322 cases/1,420 controls) 14 , 31 – 33 , ulcerative colitis (6 studies; 1,555 cases/2,295 controls) 13 , 34 – 38 , and Crohn’s disease (4 studies; 946 cases/1,390 controls) 34 – 36 , 39 . Three articles investigated both ulcerative colitis and Crohn’s disease 34 – 36 .…”

“…An increased risk of inflammatory bowel disease was observed among Fok I f allele carriers compared to F allele carriers in the present meta-analysis. Several studies have reported significant positive associations of Fok I polymorphism with Crohn’s disease 35 , 36 , 39 and ulcerative colitis 13 , 35 – 38 . In a Chinese case-control study 38 , the Fok I f allele was more frequently observed in patients with severe ulcerative colitis than in those with mild or moderate ulcerative colitis.…”

“…Several studies have reported significant positive associations of Fok I polymorphism with Crohn’s disease 35 , 36 , 39 and ulcerative colitis 13 , 35 – 38 . In a Chinese case-control study 38 , the Fok I f allele was more frequently observed in patients with severe ulcerative colitis than in those with mild or moderate ulcerative colitis. Additionally, several previous studies have examined the VDR Fok I variant in relation to colorectal adenoma 14 , 31 – 33 , a precursor lesion for colorectal cancer.…”

The Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Disease

“…As proof of concept for the role of vitamin D in the pathogenesis of IBD, the vitamin D receptor gene maps to a region of chromosome 12, which is also linked to IBD [36]. Moreover, polymorphisms of the vitamin D receptor have been linked to IBD phenotypes, pointing toward a relationship between altered affinity of vitamin D to its receptor and IBD [49][50][51][52][53][54][55].…”

“…These patients had a higher risk of developing the peculiar penetrating CD phenotype and a higher risk of IBD-related surgery. Zheng et al examined the association between VDR polymorphisms and the serum level of 25-hydroxyvitamin D in a Chinese Han population of UC and controls; they found a significant correlation between FokI polymorphism and vitamin D deficiency (<20 ng/mL) in UC patients, and between such polymorphism and UC severity of disease [55]. In contrast, BsmI polymorphism and the frequency of the AAC haplotype formed by BsmI, ApaI and TaqI were significantly lower in UC compared with controls.…”