The association between vitamin D receptor gene polymorphism (FokI), type 2 diabetes, and microvascular/macrovascular complications in postmenopausal women

Mohamed, Shimaa; Shipl, Walaa; Sarhan, Omayma H Mohamed; Sakar, Hala E; Arfa, Asmaa E

doi:10.4103/azmj.azmj_76_19

Cited by 2 publications

(4 citation statements)

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“…However, this percentage is lower than Arkkila et al 24 This study showed a significant association between LJM and the long duration of DM, as shown in Table 2. This finding is consistent with Amer et al 17 who concluded that joint limitation and stiffness in T1DM were strongly related to the duration of the disease and was the main generator for nonenzymatic glycosylation of collagens and tissues in small joints. This association is also documented by Clarke et al 22 While a significant correlation between HbA1c and LJM was reported in a previous study, 17 Clarke et al 22 and this study (Table 2) failed to find a similar correlation.…”

Section: Discussionsupporting

confidence: 92%

“…This finding is consistent with Amer et al 17 who concluded that joint limitation and stiffness in T1DM were strongly related to the duration of the disease and was the main generator for nonenzymatic glycosylation of collagens and tissues in small joints. This association is also documented by Clarke et al 22 While a significant correlation between HbA1c and LJM was reported in a previous study, 17 Clarke et al 22 and this study (Table 2) failed to find a similar correlation. Moreover, the occurrence of LJM was not related to age, height, and BMI (Table 2).…”

Section: Discussionsupporting

confidence: 92%

“…Connective tissue disorders, neuropathy, vasculopathy, or a combination of these problems may highlight the increased occurrence of musculoskeletal conditions in T1DM patients. 17 AGEs make cross-links with collagen in the skin, ligaments, and tendons, rendering them resistant to the collagenase enzyme. This mechanism could cause the development of LJM.…”

Section: Discussionmentioning

confidence: 99%

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Risk factors of limited joint mobility in type 1 diabetic adolescents: a two-center experience in Iraq

2023

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BACKGROUND Limited joint mobility (LJM) is the most common joint-related complications in patients with diabetes mellitus (DM) and indicates the presence of microvascular complications. This study aimed to assess the frequency of LJM among adolescents with type 1 DM (T1DM), its risk factors, and the other microangiopathies. METHODS In this cross-sectional study, 75 patients (adolescents between 10 and 17 years old) with T1DM were assessed for hand joint mobility using a prayer sign test. It was carried out from January 15 to June 1, 2022 in Baghdad city, Iraq. The patients’ height, body mass index, blood pressure, glycated hemoglobin, and low-density lipoprotein (LDL) were recorded. Only 44 subjects were screened for diabetic nephropathy and 64 for diabetic retinopathy based on the eligibility criteria by the American Diabetes Association guidelines. RESULTS Mean age was 13.60 (1.85) years, with a mean diabetes duration of 5.61 (2.87) years. LJM was found in 18 patients (24%). It was associated with a longer duration of diabetes (p<0.001), high LDL level (p = 0.012), diabetic nephropathy (p = 0.04), and diabetic retinopathy (p<0.001). CONCLUSIONS The proportion of LJM was high among adolescents with T1DM, especially in those with a long duration of DM. It was associated with high LDL levels and diabetic microangiopathies (nephropathy and retinopathy).

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Risk factors of limited joint mobility in type 1 diabetic adolescents: a two-center experience in Iraq

2023

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“…An increase of the (f) allele and (Ff+ff) genotypes was seen in the DM group of the current study compared to the control group. In agreement with Eweida et al [23] , and Mohamed et al [24] , who suggested that there was a high prevalence of (f) allele of VDR FokI genotype in T2DM in comparison with the controls in the Egyptian population. In addition, Gendy et al suggested that there was a significant difference between patients with type 2 diabetes mellitus and controls regarding the distribution of FokI genotypes and alleles with an increase in the frequency of (ff) genotype in patients with T2DM [25] .…”

Section: Discussionsupporting

confidence: 90%

Association Study of Vitamin D Deficiency and its receptor Gene Polymorphism in Diabetic Nephropathy

Elhuseiny,

Ezz,

Mohamed

et al. 2024

Egyptian Journal of Pure and Applied Science

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Vitamin D deficiency and polymorphisms in the vitamin D receptor (VDR) gene have been linked to type 2 diabetes (T2DM) and diabetic nephropathy. This study aimed to evaluate the prevalence of vitamin D deficiency and VDR gene polymorphisms (ApaI rs7975232 and FokI rs2228570) in Egyptian patients with T2DM and to determine their associations with the development of diabetic nephropathy. A total of 75 patients with end-stage renal disease (ESRD), 75 patients with T2DM, 75 patients with diabetic nephropathy, and 30 normal controls were included in the study. Biochemical analysis was performed, including measurements of 25-hydroxy vitamin D [25(OH)D], fasting blood sugar (FBS), postprandial sugar (PPS), homeostatic model assessment of insulin resistance (HOMA-IR), fasting insulin, glycated hemoglobin (HbA1c), blood urea, serum creatinine, estimated glomerular filtration rate (eGFR), albumin-creatinine ratio, total calcium, phosphorus, and lipid profile. VDR gene polymorphisms were detected using the PCR-RFLP technique. The results showed significantly lower levels of vitamin D in patients with T2DM (31.9 ± 8.1 ng/ml) and diabetic nephropathy (10.8 ± 8.1 ng/ml) compared to control subjects (44.9 ± 20.7 ng/ml) (P < 0.001). Vitamin D insufficiency was more prevalent in patients with T2DM and diabetic nephropathy. There was a significant increase in the frequencies of the (ff) and (AA) genotypes and the (f) and (A) alleles in the T2DM group. In conclusion, our study found a high prevalence of vitamin D deficiency in Egyptian patients with T2DM and diabetic nephropathy. There were also significant differences in the distribution of FokI genotypes and alleles between patients with T2DM and controls, suggesting a potential risk factor for Egyptian patients with T2DM. However, the (a) allele of the ApaI genotype appeared to have a protective effect in Egyptian patients.

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The association between vitamin D receptor gene polymorphism (FokI), type 2 diabetes, and microvascular/macrovascular complications in postmenopausal women

Cited by 2 publications

References 1 publication

Risk factors of limited joint mobility in type 1 diabetic adolescents: a two-center experience in Iraq

Risk factors of limited joint mobility in type 1 diabetic adolescents: a two-center experience in Iraq

Association Study of Vitamin D Deficiency and its receptor Gene Polymorphism in Diabetic Nephropathy

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