The Association Between Vitamin D Level and PFAPA Syndrome: A Systematic Review

Faydhi, Sara A.; Kanawi, Hala M. Ali; Al-Khatib, Talal; Zawawi, Faisal

doi:10.1007/s12070-021-02913-1

Cited by 1 publication

(1 citation statement)

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“…Vitamin D deficiency in RAS‐related diseases such as Behcet's syndrome and PFAPA (priodic fever, aphthous stomatitis, pharangits, and cervical adenitis) that one of the main symptoms of which is RAS, has been proven (Aslan et al, 2017 ; Faydhi et al, 2022 ). According to Ainure Oztekin study, patients with RAS could benefit from taking vitamin D as a supportive treatment (Öztekin & Öztekin, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Serum level of vitamin D in patients with recurrent aphthous stomatitis: A systematic review and meta‐analysis of case control studies

Safari‐Faramani,

Salehi,

Ghambari Haji Shore

et al. 2023

Clinical & Exp Dental Res

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ObjectivesRecurrent aphthous stomatitis (RAS) is an ulcerative condition with unknown etiology. The effect of vitamin D in the etiology of RAS is still a matter of controversy. In this study, we aimed at review the available evidence on the role of vitamin D deficiency in RAS etiology.Material and MethodsPubMed, Cochrane Library for Systematic Reviews, ISI Web of Science, Scopus, and EmBase were systematically searched for evidence on RAS and vitamin D up to January 2020. Retrieved records were screened and assessed by two of the authors independently. Newcastle−Ottawa scale was used to assess the quality of individual studies. AMSTAR tool was used for assessing the quality of the study.ResultsEight studies including 383 healthy control and 352 patients with RAS were eligible for the meta‐analysis. Serum vitamin D levels were significantly lower in RAS patients. The weighted mean difference was −7.90 (95% CI: −11.96 to −3.85).ConclusionsThe results highlighted the importance of vitamin D deficiency in the etiology of RAS. However, more studies are needed to reach a robust decision. The observed association between vitamin D and RAS is probably due to the effect of vitamin D on the immune system.

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Section: Discussionmentioning

confidence: 99%