The Association Between Vaginal Microbiota Dysbiosis, Bacterial Vaginosis, and Aerobic Vaginitis, and Adverse Pregnancy Outcomes of Women Living in Sub-Saharan Africa: A Systematic Review

Juliana, Naomi C. A.; Suiters, Meghan J. M.; Al‐Nasiry, Salwan; Morré, Servaas A.; Peters, Remco P. H.; Ambrosino, Elena

doi:10.3389/fpubh.2020.567885

Cited by 52 publications

(47 citation statements)

References 124 publications

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“…In addition, the increased risk of PROM is associated with aerobic vaginitis (p < 0.05) (44). Consistently, Naomi Juliana et al found that in Nigerian pregnant women, bacterial vaginosis is not associated with miscarriage and intrauterine growth retardation, but is associated with PROM, PTD, and low birth weight (45).…”

Section: The Vaginal Microbiota and Aposmentioning

confidence: 84%

The Role of Microbiota in Infant Health: From Early Life to Adulthood

et al. 2021

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From early life to adulthood, the microbiota play a crucial role in the health of the infant. The microbiota in early life are not only a key regulator of infant health but also associated with long-term health. Pregnancy to early life is the golden time for the establishment of the infant microbiota, which is affected by both environmental and genetic factors. Recently, there is an explosion of the studies on the role of microbiota in human diseases, but the application to disease or health is relatively limited because many aspects of human microbiota remain controversial, especially about the infant microbiota. Therefore, a critical and conclusive review is necessary to understand fully the relationship between the microbiota and the health of infant. In this article, we introduce in detail the role of microbiota in the infant from pregnancy to early life to long-term health. The main contents of this article include the relationship between the maternal microbiota and adverse pregnancy outcomes, the establishment of the neonatal microbiota during perinatal period and early life, the composition of the infant gut microbiota, the prediction of the microbiota for long-term health, and the future study directions of microbiota.

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Section: The Vaginal Microbiota and Aposmentioning

confidence: 84%

The Role of Microbiota in Infant Health: From Early Life to Adulthood

et al. 2021

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“…Donders et al observed that South African women with little or no Lactobacilli were 3.6 times more likely to have an infant with low birthweight (< 2 kg) compared to women with a high abundance of Lactobacilli [97]. Discussion on the mechanisms behind this possible causal effect of VMB dysbiosis on several adverse pregnancy outcomes were previously reviewed and are outside the scope of this review [1,98]. Nevertheless, there is a need for future studies using newer molecular diagnostic techniques to confirm these findings and determine whether low birthweight, preterm birth, or other adverse pregnancy outcomes are generally associated with maternal VMB composition in sub-Saharan African women.…”

Section: Vmb Characteristics and Pregnancy Outcomementioning

confidence: 99%

Composition of the vaginal microbiota during pregnancy in women living in sub-Saharan Africa: a PRISMA-compliant review

Juliana

Peters

Al‐Nasiry

et al. 2021

BMC Pregnancy Childbirth

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Background The vaginal microbiota (VMB) are the set of microorganisms residing in the human vagina. During pregnancy, their composition is Lactobacillus-dominant in most Caucasian women. Previous studies suggest that the VMB of women with African ancestry is more likely to be non-Lactobacillus dominant (dysbiotic) compared to other populations, and possibly relate to the high incidence of pregnancy complications, such as preterm birth. This work reviewed the literature on VMB composition in pregnant women from sub-Saharan Africa. Methods A search was conducted in PubMed and Embase databases following PRISMA guidelines. Observational and intervention studies analysing VMB communities from sub-Saharan African pregnant women using molecular techniques were included. Results Ten studies performed in seven sub-Saharan African countries were identified. They independently showed that Lactobacillus-dominant VMB (particularly L. iners or L. crispatus) or VMB containing Lactobacilli are the most prevalent, followed by a more diverse anaerobe-dominant VMB, in the studied populations. The majority of pregnant women with a sexually-transmitted infection had a Lactobacillus-dominant VMB, but with a significantly higher presence of anaerobic species. Conclusion In agreement with studies performed in other populations, Lactobacillus species are the most prevalent VMB species during pregnancy in sub-Saharan African women. The frequency of diverse anaerobe-dominant VMB is high in these populations. In Africa, studies on VMB in pregnancy are scant, heterogeneous in methodology, and knowledge remains limited. More insights on VMB composition and their possible sequalae among these populations is needed.

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“…The exclusion criteria were de ned as follows: (1) outpatients under the legal age and (2) outpatients with clinically apparent herpes simplex infection. These selected variables were based on the literature (4,6,7,(16)(17)(18)(19)(20).…”

Section: Design and Subject Selectionmentioning

confidence: 99%

“…Ethnicity and geographical location would in uence the prevalence of vaginal infections. Several authors reported different inventory of the situation about vaginal's pathobionts, namely in Asia, Europe, Africa, and Latin America (6)(7)(8). As for Sub-Saharan Africa, Kenyon et al (2013) reported a higher prevalence of BV than other parts (9).…”

Section: Introductionmentioning

confidence: 99%

An overview of vaginal infections’ etiologies in south-eastern Gabon

bignoumba

Moghoa

Muandze-Nzambe

et al. 2021

Preprint

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Discomfort in women of childbearing age associated with vaginal infections, namely Bacterial Vaginosis (BV), Aerobic Vaginitis (AV), VulVovaginal Candidiasis (VVC), and Trichomoniasis (TV), represent a serious and ongoing gynecological complication throughout the world. This study aimed to investigate the etiologies of vaginal infections among outpatients in south-eastern Gabon. A cross-sectional study was designed using participants referred directly by their treating doctor for a vaginal swab. Socio-demographic data were collected using a structured questionnaire. Microscopic examinations were used for TV and BV diagnostic. All vaginal swabs were cultured for AV and VVC isolates using standard microbiology methods. A total of 573 women of reproductive age participated in the study. The most common identified vaginal infections were BV (62.8%) and AV (51.1%) followed by VVC (34.1%). No significant difference was observed for each etiology compared to socio-demographic data. Streptococcus B (23.9%), Staphyloccocus aureus (17.7%), Klebsiella spp. (11.6%), and E. coli (5.8%) were the bacteria most associated with AV. A high incidence of Non-C. Albicans Candida (NCAC) strains causing vulvovaginitis were found. The prevalence of TV (2.1%) was low. Mixed infections had been common among participants. No association was found with TV and other vaginal infections, unlike others studies. The present study identified BV 228 (83.5%) and AV 227 (83.2%) as the main cause of mixed infections. The mixed infection AV-BV 113 (41.4%) was the most represented. Also, that simultaneous AV-BV-VVC represented 69 (25.3%) of mixed infections. Molecular analyses would be needed to identify the key species commonly associated with these vaginal infections.

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The Association Between Vaginal Microbiota Dysbiosis, Bacterial Vaginosis, and Aerobic Vaginitis, and Adverse Pregnancy Outcomes of Women Living in Sub-Saharan Africa: A Systematic Review

Cited by 52 publications

References 124 publications

The Role of Microbiota in Infant Health: From Early Life to Adulthood

The Role of Microbiota in Infant Health: From Early Life to Adulthood

Composition of the vaginal microbiota during pregnancy in women living in sub-Saharan Africa: a PRISMA-compliant review

An overview of vaginal infections’ etiologies in south-eastern Gabon

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