The association between urinary cortisol excretion and cardiovascular risk factors, bone status and quality of life in the population

Ragnarsson, Oskar; Trimpou, Penelope; Oleröd, Göran; Landin‐Wilhelmsen, Kerstin

doi:10.1016/j.steroids.2015.06.007

Cited by 8 publications

(4 citation statements)

References 39 publications

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“…Although also oral contraceptives may have had an effect on urinary cortisol levels in the AI patients, this is unlikely because age was comparable between both groups and the 3 males were in the secondary AI where urinary cortisol levels were significantly higher. While the present data point to a possible weak relationship between urinary cortisol and age, Ragnarsson and co-workers recently demonstrated in a cross-sectional study including a population sample of 348 persons aged 38-77 years that urinary free cortisol rather decreased in the elderly [15]. The number and sort of individuals included in our study is different though so that the results may not be comparable.…”

contrasting

confidence: 82%

Low Impact of Urinary Cortisol in the Assessment of Hydrocortisone Replacement Therapy

et al. 2016

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Low Impact of Urinary Cortisol in the Assessment of Hydrocortisone Replacement Therapy replacement therapy (HRT) lead to a higher prevalence of cardiovascular disease and diabetes mellitus and affect quality of life [6, 7]. Therefore, surveillance of cortisol replacement therapy is essential to avoid serious side effects. Due to the pharmacokinetic structure of oral hydrocortisone, biochemical analyses of serum cortisol are of no use and surveillance should be achieved through clinical monitoring [8]. Recently, several studies used urinary corticosteroid profiles to monitor replacement doses in patients with adrenal hypofunction [9, 10]. However, a possible difference in the metabolism of cortisol between healthy subjects and patients with primary or secondary AI may confound interpretation. In fact, little information is available whether urinary excretion of cortisol is a useful alternative to assess the quality of HRT. Aim of the present study was to perform a quantitative analysis of urinary cortisol excretion of affected AI patients compared to healthy subjects.

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confidence: 82%

Low Impact of Urinary Cortisol in the Assessment of Hydrocortisone Replacement Therapy

et al. 2016

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“…Overall, this work has provided evidence that cortisol dysregulation is associated with CVD incidence [40–44], prognosis [45, 46] and mortality [47, 48], as well as with cardiometabolic risk factors such as hypertension, hyperlipidaemia, hyperglycaemia and diabetes [49–56]. However, not all studies have found evidence supporting this link [49, 57–62], and some have reported reduced HPA-axis activity [63–66]. Additionally, there is little agreement on the types of cortisol measures that might be more predictive of CVD risk and progression across studies.…”

Section: Methods For Assessing Cortisol Levelsmentioning

confidence: 99%

Cardiovascular Disease and Hair Cortisol: a Novel Biomarker of Chronic Stress

2019

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Purpose of Review This review focuses on the concentration of cortisol in human hair as a biomarker of chronic stress in cardiovascular disease (CVD). We outline the cardiovascular consequences of cortisol excess and provide a comprehensive overview of recent studies investigating the relationship of hair cortisol with CVD. In addition, clinical implications and limitations of the evidence are discussed, together with directions for future research. Recent Findings Hair cortisol may be a reliable biomarker of chronic stress since it provides quantification of total cortisol secreted into hair over several weeks. A growing body of evidence suggests that elevated hair cortisol levels are associated with both the incidence of CVD and poorer recovery and treatment outcomes. Moreover, increased hair cortisol concentration has been linked with established cardiometabolic risk factors for CVD including high blood pressure, diabetes, and adiposity. Summary Hair cortisol is a promising biomarker of chronic cortisol excess which may contribute to both the pathogenesis and prognosis of CVD. However, the current evidence relies on small-scale cross-sectional studies. Further research adopting longitudinal designs across larger samples of CVD patients and healthy participants is required to inform the development of novel evidence-based interventions.

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“…We found that higher levels of hair cortisol in patients were correlated with a higher HRQoL, which may seem contradictory. However, this positive correlation between cortisol and HRQoL has also been shown in a large random Swedish population sample as well as in a study investigating serum cortisol levels in elderly people (Mura et al, 2014;Ragnarsson et al, 2015). It can be hypothesized that a response to stress by increasing cortisol secretion is a physiological adaptive reaction that has a positive effect on wellbeing.…”

Section: Discussionmentioning

confidence: 81%

Hair cortisol and the relationship with chronic pain and quality of life in endometriosis patients

Aken

Oosterman

Rijn

et al. 2018

Psychoneuroendocrinology

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The association between urinary cortisol excretion and cardiovascular risk factors, bone status and quality of life in the population

Cited by 8 publications

References 39 publications

Low Impact of Urinary Cortisol in the Assessment of Hydrocortisone Replacement Therapy

Low Impact of Urinary Cortisol in the Assessment of Hydrocortisone Replacement Therapy

Cardiovascular Disease and Hair Cortisol: a Novel Biomarker of Chronic Stress

Hair cortisol and the relationship with chronic pain and quality of life in endometriosis patients

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