The association between two polymorphisms in pre-miRNAs and breast cancer risk: a meta-analysis

Abstract

Emerging evidence has shown that miRNAs participate in human carcinogenesis as tumor suppressors or oncogenes. Single nucleotide polymorphism (SNP) which located in the pre-miRNA may affect the processing and then influence the expression of mature miRNA. Previous studies yielded conflicting results as to the association of two common polymorphisms in pre-miRNAs (i.e. hsa-miR-146 rs2910164 and hsa-miR-196a2 rs11614913) with breast cancer. To derive a more precise effect on the association between these polymorphisms and breast cancer risk, we conducted a meta-analysis. Through retrieving PubMed for the period up to May 2010, a total of four studies were identified with 3,007 cases and 3,718 controls for has-miR-146a rs2910164 polymorphism and with 3,287 cases and 4,298 controls for hsa-miR-196a2 rs11614913 polymorphism. We found that individuals carrying CC genotype of has-miR-196a2 rs11614913 polymorphism was associated with an increased breast cancer risk in homozygote comparison (OR = 1.30; 95% CI, 1.01-1.68), and dominant model (OR = 1.11; 95% CI, 1.01-1.23). However, no significant association between has-miR-146a rs2910164 polymorphism and breast cancer risk was observed in all comparison models tested. These findings suggest that has-miR-196a2 rs11614913 polymorphism may play crucial roles in breast cancer development.

miR-499A>G rs3746444 and miR-146aG>C expression and hepatocellular carcinoma risk in the Chinese population

“…A previous experimental study indicated that MiRNA has a key influence on tumor biology and is related to the progression and prognosis of cancer, and that the high expression of miR-499A>G in serum was significantly associated with a longer survival of non-small cell lung cancer (Hu et al, 2010;Liu et al, 2011). Common single nucleotide polymorphisms in premiRNA, rs3746444 in miR-499A>G and rs2910164 in miR-146aG>C, have been studied in various cancers, such as breast cancer, gastric cancer, cervical squamous cell cancer and colorectal cancer (Catucci et al, 2010;Okubo et al, 2010;Gao et al, 2011;Zhou et al, 2011;Srivastava and Srivastava, 2012;Wang et al, 2012). However, the results of these studies were inconsistent.…”

Meta-analysis confirms that a common G/C variant in the pre-miR-146a gene contributes to cancer susceptibility and that ethnicity, gender and smoking status are risk factors

“…However, association studies with small sample sizes lack statistical power and may produce conflicting conclusions. During the preparation of this manuscript, several metaanalyses concerning rs2910164 polymorphism and cancer risk were published (Gao et al, 2011;Qiu et al, 2011;Xu et al, 2011;Wang et al, 2012). However, these studies have not addressed the interaction of compounding factors.…”

Association between the hsa-miR-146a rs2910164 functional polymorphism with susceptibility to intracranial aneurysm

“…For instance, there have been reports that the hsa-miR-146a rs2910164 polymorphism was positively associated with asthma (Jiménez-Morales et al, 2012) and systemic sclerosis (Sakoguchi et al, 2013). Nevertheless, negative results have been found for this variant in systemic lupus erythematosus, rheumatoid arthritis, and moyamoya disease (Gao et al, 2010;Zhang et al, 2010;Löfgren et al, 2012;Park et al, 2012).…”