The association between tobacco burden and “dirty chest” is unlikely to follow a linear dose-response pattern

Laney, A. S.; Tramma, S; Petsonk, EL; Attfield,

doi:10.1259/bjr/27455728

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…to radiographic interstitial fibrosis in two large workforces exposed chest" issue. [30][31][32] While questions have been raised regarding the methodology used in some of these studies 33,34 , our study showed a statistically significant increase in rates of abnormal ILO readings, both for parenchymal abnormalities and profusion scores with the exception of category 1/1, in former and current smokers compared to never smokers. Detailed smoking history was not available to further explore this association, but these findings certainly warrant the need for further studies and recommendations for ILO readers with regards to the significance of the smoking history.…”

Section: Disclosure Statementmentioning

confidence: 68%

Lower limit of normal based spirometric abnormalities associated with radiographic abnormality in an elderly cohort at low risk for exposure

Mikulski

Gerke

Newell

et al. 2016

International Journal of Occupational and Environmental Health

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Background: Although the relation between radiographic abnormalities and spirometric impairment in people with asbestosis has been studied extensively, the extent of spirometric impairment associated with milder radiographic abnormalities is not established. Objective: To test associations between mild radiographic abnormalities and Lower Limit of Normal (LLN)-based spirometry interpretation. Methods: Spirometry and CXRs were collected for 1,026 at low risk of exposure to pneumoconiotic agents participants in a medical screening program. Results: Individuals with each type of isolated or combined International Labour Organization (ILO) abnormalities had up to over sixfold statistically significant increase in odds of LLN-based restrictive pattern physiology (OR = 1.96, 95%CI 1.03-3.73 for parenchymal to OR = 6.09, 95%CI 1.94-19.10 for parenchymal and pleural) compared to those with normal films. Conclusions: The findings from this study confirm the association of mild profusion abnormalities with clinically relevant, LLN-based lung function abnormalities.

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