The association between thyroid disorders and incident gout: population-based case&amp;ndash;control study

Bruderer, Saskia Gabriela; Meier, Christoph; Jick, Susan S.; Bodmer, Michael

doi:10.2147/clep.s128627

Cited by 7 publications

(8 citation statements)

References 29 publications

(57 reference statements)

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“…The association between hypothyroidism and hyperuricemia (an important risk factor for the development of gout) has been firmly established. [35][36][37][38][39][40][41][42][43][44] Depression: Globally, the total number of people living with depression was estimated to exceed 300 million in 2015, equivalent to 4.4% of the world's population. This estimation increased by 18.4% between 2005 and 2015.…”

Section: Specified Areas Of Preventive Carementioning

confidence: 99%

New era of community pharmacists in patient problem solving and preventive care

Mohiuddin¹

2020

JCHM

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As important members of the health care team, pharmacists work collaboratively with patients' other health care providers in all types of patient care settings ranging from community pharmacies to hospitals and long-term care facilities. Across these settings, pharmacists take specific actions that regularly contribute to improving patient safety. In addition to training on medications, pharmacist education and training includes assessing health status of patients, providing education and counseling, managing diseases, and using health care technologies. Pharmacists use this education and training to prevent medication errors, drug interactions, and other adverse medication events from reaching patients. With the expanding number and complexity of medications, pharmacists' roles and responsibilities have expanded broadly beyond medication distribution. Pharmacists are providing patient care in almost all health care settings to help people of all ages get the most from the medications that are prescribed to them. Examples of pharmacists' patient care services include providing health and wellness screenings, managing chronic diseases, assisting patients with medication management, administering immunizations, and working with hospitals and health systems to improve patient care and reduce the number of patients who are readmitted to the hospital following their hospital stay.

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Section: Specified Areas Of Preventive Carementioning

confidence: 99%

New era of community pharmacists in patient problem solving and preventive care

Mohiuddin¹

2020

JCHM

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“…The literature search initially yielded 955 abstracts, and 46 studies were assessed for eligibility by reading full texts. Thirty-two stud-ies were excluded and 14 studies meeting the inclusion criteria were considered eligible [21][22][23][24][25][26][27][28][29][39][40][41][42]. ▶ table 3 showed the characteristics of those 14 included studies.…”

Section: Meta-analysismentioning

confidence: 99%

“…There were 7 cross-sectional studies, 6 case-control studies and one cohort study. There were 9 studies assessing the impact of gout on hypothyroidism risk [21-24, 26, 39, 41, 42], 4 studies assessing the impact of gout on hyperthyroidism [23,24,26], 8 studies assessing the impact of hyperuricemia on hypothyroidism risk [23, 25, 27-29, 40, 41], and 6 studies assessing the impact of hyperuricemia on hyperthyroidism risk [23,25,27,29,40] (▶ table 3). Based on the NOS criteria, 12 studies had good quality, but the other 2 studies had suboptimal quality.…”

Section: Meta-analysismentioning

confidence: 99%

“…A plethora of published studies have revealed that both gout and hyperuricemia are associated with cardiovascular diseases and premature death [16,[18][19][20]. Some observational studies explored whether gout and hyperuricemia were potentially related to thyroid dysfunction including hypothyroidism and hyperthyroidism, but there was lack of consistent findings [21][22][23][24][25][26][27][28][29]. Several of them found that thyroid dysfunction was not significantly related to gout and hyperuricemia [22,23,[27][28][29].…”

Section: Introductionmentioning

confidence: 99%

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Risk of Thyroid Disorders in Patients with Gout and Hyperuricemia

Wang

et al. 2019

Horm Metab Res

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The risk of thyroid autoimmunity and thyroid dysfunction among patients with gout and hyperuricemia has not been well defined. This study was undertaken to examine the impact of gout and hyperuricemia on risk of thyroid disorders including thyroid autoimmunity and thyroid dysfunction. A population-based cross-sectional study was conducted to assess the risk of thyroid autoimmunity and thyroid dysfunction related to gout and hyperuricemia, which included 115 gout patients, 439 hyperuricemic patients, and 2 254 individuals without gout and hyperuricemia. A systematic review and meta-analysis of 14 observational studies was also done to systematically evaluate the risk of thyroid dysfunction among patients with gout and hyperuricemia. Findings from the cross-sectional study suggested a significantly increased risk of hypothyroidism among female gout patients (OR=2.44, 95% CI 1.15–5.17, p=0.02). Besides, gout could also substantially increase risk of Hashimoto’s thyroiditis in women (OR=3.15, 95% CI 1.53–6.49, p=0.002). The meta-analysis proved a considerably increased risk of hypothyroidism among both gout patients (OR=1.51, 95% CI 1.23–1.85, p<0.001) and hyperuricemic patients (OR=1.34, 95% CI 1.11–1.61, p=0.002). Moreover, this meta-analysis also suggested that gout could also significantly increase the risk of hyperthyroidism (OR=1.25, 95% CI 1.06–1.48, p=0.01). The findings from the study suggest increasing risk of hypothyroidism and Hashimoto’s thyroiditis among gout patients. Moreover, gout but not hyperuricemia is linked to increased risk of hyperthyroidism. More studies are warranted to elucidate the influence of gout and hyperuricemia on thyroid disorders.

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“…Furthermore, a few prior studies have suggested a relationship between gout and thyroid abnormalities, with a few conflicting results [ 10 ]. Thyroid cancer is associated with benign thyroid diseases, including hyperthyroidism, thyroiditis, and autoimmune thyroid diseases [ 11 ]. In addition, both thyroid cancer and gout are associated with metabolic disorders.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Gout on Thyroid Cancer Incidence: A Nested Case-Control Study Using a National Health Screening Cohort

Kim

Yoo

Kwon

et al. 2022

JPM

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In this study, we investigated the risk of thyroid cancer in patients with gout. Participants ≥ 40 years old in the Korean National Health Insurance Service–Health Screening Cohort were investigated. A total of 5844 patients with thyroid cancer were paired with 23,376 comparison participants (no history of thyroid cancer) to build the nested case–control study. A previous history of gout was collected from both the thyroid cancer and comparison participants. The relationship of thyroid cancer with a prior history of gout was analyzed using a conditional logistic regression model. The rate of gout was higher in the patients with thyroid cancer than in the comparison group. In the total study population, the relationship of thyroid cancer with a prior history of gout was not statistically evident. A previous history of gout was related to an increased risk of gout in the < 60 years old, normal weight, abnormal blood pressure, and CCI score = 0 groups. The occurrence of thyroid cancer was not associated with a prior history of gout in the general adult population. However, a prior history of gout was related to an elevated risk of thyroid cancer in middle-aged and healthy populations without comorbidities.

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The association between thyroid disorders and incident gout: population-based case–control study

Cited by 7 publications

References 29 publications

New era of community pharmacists in patient problem solving and preventive care

New era of community pharmacists in patient problem solving and preventive care

Risk of Thyroid Disorders in Patients with Gout and Hyperuricemia

The Effect of Gout on Thyroid Cancer Incidence: A Nested Case-Control Study Using a National Health Screening Cohort

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