The association between the triglyceride to high-density lipoprotein cholesterol ratio with insulin resistance (HOMA-IR) in the general Korean population: Based on the National Health and Nutrition Examination Survey in 2007–2009

Kim, Jong-Seok; Kang, Hee-Taik; Shim, Jae‐Yong; Lee, Hye-Ree

doi:10.1016/j.diabres.2012.04.022

Cited by 59 publications

(52 citation statements)

References 21 publications

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“…In Chinese women with PCOS, serum lipoprotein ratios such as the TG/HDL-C ratio, total cholesterol to HDL cholesterol ratio, and low-density lipoprotein cholesterol to HDL cholesterol ratio were higher compared with those of the healthy controls, and the TG/HDL-C ratio was significantly correlated with a homeostasis model assessment of insulin resistance (HOMA-IR) 17. Additionally, there was a significant correlation between the TG/HDL-C ratio and IR in both men and women in the general population 1819. However, a cutoff value of the TG/HDL-C ratio for predicting IR or metabolic disorders has not been suggested in Korean women with PCOS.…”

Section: Introductionmentioning

confidence: 91%

Triglycerides to High-Density Lipoprotein Cholesterol Ratio Can Predict Impaired Glucose Tolerance in Young Women with Polycystic Ovary Syndrome

et al. 2016

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PurposeThe triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio could be related to insulin resistance (IR). We previously reported that Korean women with polycystic ovary syndrome (PCOS) had a high prevalence of impaired glucose tolerance (IGT). We aimed to determine the cutoff value of the TG/HDL-C ratio for predicting IR and to examine whether the TG/HDL-C ratio is useful for identifying individuals at risk of IGT in young Korean women with PCOS.Materials and MethodsWe recruited 450 women with PCOS (24±5 yrs) and performed a 75-g oral glucose tolerance test (OGTT). IR was assessed by a homeostasis model assessment index over that of the 95th percentile of regular-cycling women who served as the controls (n=450, 24±4 yrs).ResultsThe cutoff value of the TG/HDL-C ratio for predicting IR was 2.5 in women with PCOS. Among the women with PCOS who had normal fasting glucose (NFG), the prevalence of IGT was significantly higher in the women with PCOS who had a high TG/HDL-C ratio compared with those with a low TG/HDL-C ratio (15.6% vs. 5.6%, p<0.05).ConclusionThe cutoff value of the TG/HDL-C ratio for predicting IR was 2.5 in young Korean women with PCOS, and women with NFG and a high TG/HDL-C ratio had a higher prevalence of IGT. Therefore, Korean women with PCOS with a TG/HDL-C ratio >2.5 are recommended to be administered an OGTT to detect IGT even if they have NFG.

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Section: Introductionmentioning

confidence: 91%

Triglycerides to High-Density Lipoprotein Cholesterol Ratio Can Predict Impaired Glucose Tolerance in Young Women with Polycystic Ovary Syndrome

et al. 2016

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“…Previous studies have demonstrated that fasting insulin and homeostasis model assessment (HOMA) are markers of IR [7] but there has been no attempt to standardize assays of insulin concentration to date. The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio concentration has been reported to be closely related to IR in adults [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Is triglyceride to high-density lipoprotein cholesterol ratio a surrogates for insulin resistance in youth?

Oliveira¹,

Oliveira²,

Oliveira³

et al. 2013

Health

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As elevated triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio has been described as predictor for cardio metabolic disease with insulin resistance (IR) in the background, the aim was to assess the relationship between this ratio and IR in youth. Oral glucose tolerance test was performed in 318 Brazilian students (175 girls, 11.2 ± 3.2 years, BMI_z-score 1.2 ± 1.4 SD). Measurements: BMI, waist circumference (WC), blood pressure (BP), lipids, insulin and high sensitivity C-reactive protein (hsCRP). Excessive weight and abdominal obesity were defined using BMI_z-score and WC and IR by Homeostasis model assessment-insulin resistance (HOMA-IR). TG/HDL-C median was 2.37. There was an association between TG/ HDL-C and WC, systolic and diastolic BP, insulin, HOMA-IR, hsCRP, (p < 0.001). Stratified TG/HDL-C into two groups, based on a cut off point of 2.73 (Group 1: <2.73 and Group 2: ≥2.73). Adjusting for age, gender, ethnicity TG/HDL-C was an independent variable predicting IR (PR = 1.44; CI: 1.07 -1.96; p = 0.018). For every 1 (cm) in WC increased there was an addition of 0.04 of the value of TG/HDL-C and in those with TG/HDL-C ≥ 2.73 for every 10 (cm) increase in WC there was an improve of 4% in the ratio. In conclusion: In youth, the TG/HDL-C ratio could be a useful index for identifying groups with IR.

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“…It is therefore important to achieve good glycemic control in patients with diabetes for the prevention and improvement of NAFLD. We further found that not only baseline level of TG/HDL-C ratio, a surrogate marker for insulin resistance [38], but also change in TG/HDL-C ratio were significantly associated with the change in hepatic steatosis. Insulin resistance has been reported to be associated with NAFLD regardless of glucose levels [39] and patients with NAFLD have reduced insulin sensitivity in the muscle, liver, and adipose tissue.…”

Section: Discussionmentioning

confidence: 99%

Gender difference in the impact of gynoid and android fat masses on the progression of hepatic steatosis in Japanese patients with type 2 diabetes

et al. 2017

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BackgroundIncreased visceral adiposity is strongly associated with non-alcoholic fatty liver disease (NAFLD). However, little attention has been paid to the association between the change in subcutaneous adipose mass and the progression of non-alcoholic fatty liver disease (NAFLD). We aimed to investigate whether increased subcutaneous adipose tissue (gynoid fat mass) could be protective against the progression of NAFLD in Japanese patients with type 2 diabetes.MethodsThis is a retrospective observational study of 294 Japanese patients with type 2 diabetes (65 ± 10 years old, 40% female). Liver attenuation index (LAI) measured by abdominal computed tomography was used for the assessment of hepatic steatosis. Both gynoid (kg) and android (kg) fat masses were measured by the whole body dual-energy X-ray absorptiometry. One-year changes in LAI, gynoid, and android fat masses were evaluated in both male and female patients. Linear regression analysis with a stepwise procedure was used for the statistical analyses to investigate the association of the changes in gynoid and android fat masses with the change in LAI.ResultsLAI levels at baseline were 1.15 ± 0.31 and 1.10 ± 0.34 in female and male patients (p = 0.455). The change in gynoid fat mass was significantly and positively associated with the change in LAI in both univariate (standardized β 0.331, p = 0.049) and multivariate (standardized β 0.360, p = 0.016) models in the female patients. However, no significant association was observed in males. In contrast, the increase in android fat mass was significantly associated with the reduced LAI in both genders in the multivariate models (standardized β −0.651, p < 0.001 in females and standardized β −0.519, p = 0.042 in males).ConclusionsThis study provides evidence that increased gynoid fat mass may be protective against the progression of NAFLD in female Japanese patients with type 2 diabetes.

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The association between the triglyceride to high-density lipoprotein cholesterol ratio with insulin resistance (HOMA-IR) in the general Korean population: Based on the National Health and Nutrition Examination Survey in 2007–2009

Cited by 59 publications

References 21 publications

Triglycerides to High-Density Lipoprotein Cholesterol Ratio Can Predict Impaired Glucose Tolerance in Young Women with Polycystic Ovary Syndrome

Triglycerides to High-Density Lipoprotein Cholesterol Ratio Can Predict Impaired Glucose Tolerance in Young Women with Polycystic Ovary Syndrome

Is triglyceride to high-density lipoprotein cholesterol ratio a surrogates for insulin resistance in youth?

Gender difference in the impact of gynoid and android fat masses on the progression of hepatic steatosis in Japanese patients with type 2 diabetes

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