The Association between the Serum Uric Acid Level and Hypertension in Middle-Aged and Elderly Adults

Abstract

Background. Studies on serum uric acid (sUA) levels and hypertension (HTN) are controversial. To investigate the association between the sUA level and the incident of HTN in middle-aged and elderly adults, we performed this study. Methods. 6399 participants aged ≥40 years from the National Health and Nutrition Examination Survey (NHANES) were included. Weighted multiple logistic regression analysis was carried out to evaluate the relationship between the sUA level and the incident of HTN, exploring the potential nonlinear relationship using the fitted smoothing curves. If nonlinearity was observed, the inflection point was further calculated by a recursive algorithm. Results. A positive relationship between the sUA level and the incident of HTN was found. However, it may differ in different race groups, nor between male and female. Moreover, the association between the sUA level and the incident of HTN followed a U-shaped curve in male (turning point: sUA 4.1 mg/dL) and Whites (turning point: sUA 7.9 mg/dL). Conclusions. The results revealed that the sUA level is positively correlated with the incident of HTN, in middle-aged and elderly adults. However, it followed a U-shaped curve in males and Whites.

Association between serum uric acid levels and achievement of target blood pressure among Japanese community residents with hypertension

“…These cofounders, especially BMI, were chosen referring to previous reports. 9,20,21 The odds ratio (OR) and 95% confidence interval (CI)…”

“…Model 2 was adjusted for age (years), BMI (kg/m2), alcohol consumption (usual drinker), smoking behavior (current smoker), medical history of diabetes mellitus (yes), medical history of dyslipidemia (yes), and CKD (present). These cofounders, especially BMI, were chosen referring to previous reports 9,20,21 . The odds ratio (OR) and 95% confidence interval (CI) were calculated for each factor via multivariate logistic regression analysis.…”

“…Hyperuricemia is also recognized as an important risk factor for cardiovascular disease, renal dysfunction, and gout 5–7 . In recent years, an association between elevated serum uric acid (SUA) and hypertension has also received widespread attention 8–10 . Hyperuricemia is suggested to play a role in the development of hypertension, and a causal relationship between the two has been suggested 8 .…”

“…[5][6][7] In recent years, an association between elevated serum uric acid (SUA) and hypertension has also received widespread attention. [8][9][10] Hyperuricemia is suggested to play a role in the development of hypertension, and a causal relationship between the two has been suggested. 8 Previous studies have also reported an association between elevated SUA and cardiovascular events in patients with hypertension.…”

Relationship between serum uric acid and hypertension in the general US population aged 20 years and older: A cross-sectional study based on NHANES 2007 to 2016

“…This would ultimately lead to vasoconstriction and hypertension. [17][18][19] UA is emerging as a potentially manageable risk factor for cardiometabolic illness, according to recent studies. [20] Increased serum UA has been linked to hypertension, according to several national epidemiological studies, however the results are not totally consistent.…”