The Association between the Preoperative Prognostic Nutritional Index and the Controlling Nutritional Status Score on Tumor Stage, Chemotherapeutic Response and Overall Survival in Ovarian Cancer

Karakaş, Sema; Demirayak, Gökhan; Önder, Ayşe Büşra; Özdemir, İsa Aykut; Comba, Cihan; Çaypınar, Sema Süzen; Yıldız, Şükrü; Avşar, Selim; Baghaki, Sema; Yıldız, Güneş Özlem; Erdogan, Sakir Volkan

doi:10.1080/01635581.2021.2022170

Cited by 6 publications

(15 citation statements)

References 22 publications

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“…One additional study was excluded because it did not contain survival data for analysis. In total, the present meta-analysis enrolled 6 studies, encompassing 2,569 patients [ 10 , 12 – 16 ] (Fig. 1 ; Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…Increased CONUT scores are typically associated with an unfavorable nutritional status and weakened immune responses. Numerous studies have explored whether the CONUT score can be used to predict gynecological cancer survival; however, no consistent outcomes have been obtained [ 10 , 12 – 16 ]. An increased CONUT score has been suggested, in certain articles, to be significantly related to a poor prognosis in gynecological cancer [ 10 , 13 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…An increased CONUT score has been suggested, in certain articles, to be significantly related to a poor prognosis in gynecological cancer [ 10 , 13 , 15 ]. Other studies, however, have demonstrated no obvious relationship between the CONUT score and survival outcomes in cases of gynecological cancer [ 12 , 16 ]. Therefore, in the present study, we performed a comprehensive literature search and conducted a meta-analysis to identify the relation of the CONUT score with the prognosis and clinicopathological characteristics of patients with gynecological cancer.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic and clinicopathological impacts of Controlling Nutritional Status (CONUT) score on patients with gynecological cancer: a meta-analysis

Niu

Yan

2023

Nutr J

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Background The Controlling Nutritional Status (CONUT) score has proven to be a potential biomarker for determining the prognosis of patients with various types of cancer. Its value in determining the prognosis of patients with gynecological cancer, however, remains unknown. The present study was a meta-analysis that aimed to evaluate the prognostic and clinicopathological significance of the CONUT score in gynecological cancer. Methods The Embase, PubMed, Cochrane Library, Web of Science, and China National Knowledge Infrastructure databases were comprehensively searched through November 22, 2022. A pooled hazard ratio (HR), together with a 95% confidence interval (CI), was used to determine whether the CONUT score had prognostic value in terms of survival outcomes. Using odds ratios (ORs) and 95% CIs, we estimated the relationship between the CONUT score and clinicopathological characteristics of gynecological cancer. Results We evaluated 6 articles, involving a total of 2,569 cases, in the present study. According to the results of our analyses, higher CONUT scores were significantly correlated with decreased overall survival (OS) (n = 6; HR = 1.52; 95% CI = 1.13–2.04; P = 0.006; I2 = 57.4%; Ph = 0.038) and progression-free survival (PFS) (n = 4; HR = 1.51; 95% CI = 1.25–1.84; P < 0.001; I2 = 0; Ph = 0.682) in gynecological cancer. Moreover, higher CONUT scores were significantly correlated with a histological grade of G3 (n = 3; OR = 1.76; 95% CI = 1.18–2.62; P = 0.006; I2 = 0; Ph = 0.980), a tumor size ≥ 4 cm (n = 2; OR = 1.50; 95% CI = 1.12–2.01; P = 0.007; I2 = 0; Ph = 0.721), and an advanced International Federation of Gynecology and Obstetrics (FIGO) stage (n = 2; OR = 2.52; 95% CI = 1.54–4.11; P < 0.001; I2 = 45.5%; Ph = 0.175). The correlation between the CONUT score and lymph node metastasis, however, was not significant. Conclusions Higher CONUT scores were significantly correlated with decreased OS and PFS in gynecological cancer. The CONUT score, therefore, is a promising and cost-effective biomarker for predicting survival outcomes in gynecological cancer.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prognostic and clinicopathological impacts of Controlling Nutritional Status (CONUT) score on patients with gynecological cancer: a meta-analysis

Niu

Yan

2023

Nutr J

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“…34,35 Composed of cholesterol level, albumin level, and lymphocyte count, CONUT score is related to ovarian cancer prognosis in retrospective studies. 9,36…”

Section: Discussionmentioning

confidence: 99%

“…The application is limited by their low sensitivity and specificity with AUC varies 0.63-0.709, although many scoring systems have been constructed to increase their availability. [9][10][11]14,30,33,36 In our study, we constructed a scoring system named PBS, by dichotomizing the variables and value assignment. PBS had a better performance in predicting OS in EOC patients compared with existing scoring systems and single indicators.…”

Section: Dovepressmentioning

confidence: 99%

Development of Nomogram Models Based on Peripheral Blood Score and Clinicopathological Parameters to Predict Preoperative Advanced Stage and Prognosis for Epithelial Ovarian Cancer Patients

Bai¹,

Zhou²,

Rong³

et al. 2023

JIR

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Nutritional and inflammatory states are crucial in cancer development. The purpose of this study is to construct a scoring system grounded on peripheral blood parameters associated with nutrition and inflammation and explore its value in stage, overall survival (OS), and progression-free survival (PFS) prediction for epithelial ovarian cancer (EOC) patients. Patients and Methods: Four hundred and fifty-three EOC patients were retrospectively identified and their clinical data and relevant peripheral blood parameters were collected. The ratio of neutrophil to lymphocyte, lymphocyte to monocyte, fibrinogen to lymphocyte, total cholesterol to lymphocyte and albumin level were calculated and dichotomized. A scoring system named peripheral blood score (PBS) was constructed. Univariate and multivariate Logistic or Cox regression analyses were used to select independent factors; these factors were then used to develop nomogram models of advanced stage and OS, PFS, respectively. The internal validation and DCA analysis were performed to evaluate models. Results: Lower PBS indicated a better prognosis and higher PBS indicated inferior. High PBS is associated with advanced stage, high CA125, serous histological type, poor differentiation, and accompanied ascites. The logistic regression showed age, CA125, and PBS were independent factors for the FIGO III-IV stage. The nomogram models for advanced FIGO stage based on these factors showed good efficiency. FIGO stage, residual disease, and PBS were independent factors affecting OS and PFS, the nomogram models composed of these factors had good performance. DCA curves revealed the models augmented net benefits. Conclusion: PBS can be a noninvasive biomarker for EOC patients' prognosis. The related nomogram models could be powerful, cost-effective tools to provide information of advanced stage, OS, and PFS for EOC patients.

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The Prognostic Value of Prognostic Nutritional Index in Patients with Ovarian Cancer: A Systematic Review and Meta-Analysis

Tan

Chen

2022

Nutrition and Cancer

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The Association between the Preoperative Prognostic Nutritional Index and the Controlling Nutritional Status Score on Tumor Stage, Chemotherapeutic Response and Overall Survival in Ovarian Cancer

Cited by 6 publications

References 22 publications

Prognostic and clinicopathological impacts of Controlling Nutritional Status (CONUT) score on patients with gynecological cancer: a meta-analysis

Prognostic and clinicopathological impacts of Controlling Nutritional Status (CONUT) score on patients with gynecological cancer: a meta-analysis

Development of Nomogram Models Based on Peripheral Blood Score and Clinicopathological Parameters to Predict Preoperative Advanced Stage and Prognosis for Epithelial Ovarian Cancer Patients

The Prognostic Value of Prognostic Nutritional Index in Patients with Ovarian Cancer: A Systematic Review and Meta-Analysis

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