The Association Between the Neutrophil Lymphocyte Ratio and Vitamın D Levels

Abstract

Background: Neutrophil lymphocyte ratio has been used as an indicator of systemic inflammation. Vitamin D levels have been demonstrated to be associated with infectious diseases. In this study the relationship between Vitamin D levels and neutrophil lymphocyte ratio were assessed. Materials and Methods: A total of 300 subjects who were, healthy, who did not have a chronic disease, history of drug use, inflammation, or inflammatory disease, who were not pregnant, who were admitted to Family Medicine Outpatient Clinic of Süleyman Demirel University Medical Faculty between1 September and 31 May 2015 were included in the study. Vitamin D levels and hemogram findings were evaluated retrospectively. Results: Mean age of the patients was 29, 6 ± 11 years, of the participants, 232 (77, 3%) were female and 68 (22, 7%) were male. Vitamin D levels were normal in 73 (24, 3%) participants and low in 227 (75, 7%). A negative correlation was found between Vitamin D and neutrophil lymphocyte ratio (p = 0.01, r =-0,184) and a positive correlation was observed between Vitamin D and hemoglobin levels (p=0, 01, r=0,187). A positive correlation was observed between age and hemoglobin levels (p=0.04, r=0,114). A significant correlation was not detected between Vitamin D levels and, age, hemoglobin, neutrophils, lymphocytes, eosinophil, leukocyte, platelet count (p=0, 98, p=0, 23, p=0, 13, p=0, 52, p=0, 30, p=0, 41, p=0, 67, but there is significant correlation between neutrophil lymphocyte ration p=0, 04). Conclusion: The results of the present study support that Vitamin D deficiency increases the susceptibility to inflammation. The patients who experience frequent infections should be assessed with regard to Vitamin D levels. It was concluded that normal Vitamin D levels may be required for supportive treatment of infectious diseases