The Association between the Levels of Serum Ferritin and Sex Hormones in a Large Scale of Chinese Male Population

Liu, Zhenfang; Ye, Fanghui; Zhang, Haiying; Gao, Yong; Tan, Aihua; Zhang, Shijun; Xiao, Qiang; Zhang, Bing; Huang, Lulu; Ye, Bingbing; Qin, Xue; Wu, Chunlei; Lu, Zheng; Zhang, Youjie; Liao, Ming; Yang, Xiaobo; Mo, Zengnan

doi:10.1371/journal.pone.0075908

Cited by 23 publications

(22 citation statements)

References 52 publications

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“…This analysis was performed using data from a population-based study, Fangchenggang Area Male Health and Examination Survey (FAMHES), which was described previously [12,13]. In brief, FAM-HES was conducted in Guangxi among noninstitutionalized Chinese males, which designed to investigate the effects of environmental and genetic factors and their interaction with the development of age-related chronic diseases in men.…”

Section: Study Populationmentioning

confidence: 99%

“…Blood samples were collected in the morning between 7 and 9 AM after overnight fasting (~10 h).The blood samples were used to assay serum alanine aminotransferase (ALT), total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), fasting plasma glucose (FPG), fasting serum insulin, serum SHBG, total testosterone (TT). SHBG and TT were measured with electrochemiluminescence immunoassay on COBAS 6 000 system E601 (Elecsysmodule) immunoassay analyzers (Roche Diagnostics, IN, Germany) as previously described [13,17]. Free Testosterone (FT) and bioavailable testosterone (BT) were calculated based on the detected TT as the reported method [18].…”

Section: Biochemical Measurementsmentioning

confidence: 99%

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Low Serum Sex Hormone-Binding Globulin Associated with Insulin Resistance in Men with Nonalcoholic Fatty Liver Disease

Yao

Gao

et al. 2017

Horm Metab Res

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The presence of nonalcoholic fatty liver disease (NAFLD) is a strong risk predictor for type 2 diabetes (T2D). A reduction in sex hormone-binding globulin (SHBG) is associated with NAFLD. Low SHBG is also associated with insulin resistance (IR). However, very limited data are available for the association of SHBG and IR in patients with NAFLD. The study aims to clarify the association between SHBG and IR in patients with NAFLD. In this cross-sectional study, 334 men with NAFLD were recruited. SHBG, total testosterone, free testosterone, total cholesterol, triglyceride, insulin, and glucose concentrations were measured. Homeostatic model assessment (HOMA)-IR and HOMA-β were calculated. Spearman's correlations and multiple linear regressions were used to analyze the association between SHBG and IR. Men with moderate-severe NAFLD had higher waist circumference, BMI, total cholesterol, triglyceride, insulin, HOMA-IR, HOMA-β, and free testosterone, but lower SHBG than the mild NAFLD. The moderate-severe NAFLD group exhibited higher HOMA-IR (2.38±1.35 vs. 4.16±2.84, p<0.001) and lower SHBG (25.89±11.89 vs. 30.13±12.97 nmol/l, p<0.001) than the other group. SHBG value was negatively correlated with insulin, and HOMA-IR, but was not significantly correlated with glucose and testosterone. The multiple linear regression analysis showed that SHBG was significantly associated with insulin (β=- 0.241, p<0.001), and HOMA-IR (β=- 0.229, p<0.001), even adjusting for potential confounders. In conclusion, low serum SHBG is associated with IR in men with NAFLD.

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Section: Study Populationmentioning

confidence: 99%

Section: Biochemical Measurementsmentioning

confidence: 99%

Low Serum Sex Hormone-Binding Globulin Associated with Insulin Resistance in Men with Nonalcoholic Fatty Liver Disease

Yao

Gao

et al. 2017

Horm Metab Res

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“…As the human body lacks a mechanism for eliminating iron, tissue iron overload is known to exert pathophysiological effects on androgen synthesis [15]. Elevated serum ferritin are common feature observed in obese men and serum ferritin levels are negatively correlated with serum total T levels in adult men and young adolescent boys [16,17]. A pituitary iron overload predicts hypogonadism in thalassemia patients with transfusional iron overload [18].…”

Section: Introductionmentioning

confidence: 99%

Iron and Advanced Glycation End Products: Emerging Role of Iron in Androgen Deficiency in Obesity

et al. 2020

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The literature suggests a bidirectional relationship between testosterone (T) and iron, but mechanisms underlying this relationship remain unclear. We investigated effects of iron on advanced glycation end products (AGEs) in obesity-related androgen deficiency. In total, 111 men were recruited, and iron biomarkers and N(ɛ)-(carboxymethyl)lysine (CML) were measured. In an animal study, rats were fed a 50% high-fat diet (HFD) with (0.25, 1, and 2 g ferric iron/kg diet) or without ferric citrate for 12 weeks. Obese rats supplemented with >1 g iron/kg diet had decreased testicular total T compared to HFD alone. Immunohistochemical staining showed that >1 g of ferric iron increased iron and AGE retention in testicular interstitial tissues, which is associated with increased expression of the receptor for AGEs (RAGE), tumor necrosis factor-α, and nitric oxide. Compared with normal weight, overweight/obese men had lower T levels and higher rates of hypogonadism (19% vs. 11.3%) and iron overload (29.8% vs.15.9%). A correlation analysis showed serum total T was positively correlated with transferrin saturation (r = 0.242, p = 0.007) and cathepsin D (r = 0.330, p = 0.001), but negatively correlated with red blood cell aggregation (r = −0.419, p<0.0001) and CML (r = −0.209, p < 0.05). In conclusion, AGEs may partially explain the underlying relationship between dysregulated iron and T deficiency.

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“…As only one cross-sectional study focusing on the association between ferritin and carotid atherosclerosis was conducted in postmenopausal women ( 38 ) , further studies are required to explore the associations between ferritin and carotid atherosclerosis in premenopausal women and other populations. On the other hand, oestrogen metabolites may regulate the release of Fe 2+ from ferritin ( 44 ) , and testosterone has been shown to be significantly negatively associated with ferritin levels in Asian men ( 45 ) . Therefore, differences in sex hormones may partly explain the sex-specific association between ferritin and carotid atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Increased serum ferritin levels are independently associated with carotid atherosclerosis in women

Yan-qi

et al. 2017

Br J Nutr

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Previous studies have supported the theory that there is a positive association between ferritin and carotid atherosclerosis in Western people. Diet plays an important role in determining serum ferritin concentration. Asian dietary patterns are different from Western dietary patterns, implying that there may be a difference in the association of ferritin with carotid atherosclerosis between Asian and Western people. However, few studies focus on the association between ferritin and carotid atherosclerosis among Asians. The aim of this study was to investigate how serum ferritin levels are associated with carotid atherosclerosis in an Asian adult population. A cross-sectional assessment was performed in 8302 adults in Tianjin, China. Carotid intima-media thickness (IMT) and plaques were assessed using ultrasonography, and serum ferritin was measured using the protein chip-chemiluminescence method. Multiple logistic regression analysis was used to examine the association between quartiles of serum ferritin concentration and carotid atherosclerosis. In the present study, the overall prevalence of IMT and carotid plaques in participants is 29·2 and 22·7 %, respectively. In women, after adjustments for potentially confounding factors, the OR of IMT and carotid plaques by increasing serum ferritin quartiles were 1·00, 1·39 (95 % CI 0·98-1·99), 1·39 (95 % CI 0·99-1·97), 1·81 (95 % CI 1·30-2·55) (P for trend<0·001) and 1·00, 1·24 (95 % CI 0·89-1·73), 1·18 (95 % CI 0·85-1·65), 1·59 (95 % CI 1·15-2·20) (P for trend<0·01), respectively. However, no association was found between serum ferritin and carotid atherosclerosis in men. The study demonstrated that increased serum ferritin levels are independently associated with IMT and carotid plaques in Asian women but not in Asian men.

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The Association between the Levels of Serum Ferritin and Sex Hormones in a Large Scale of Chinese Male Population

Cited by 23 publications

References 52 publications

Low Serum Sex Hormone-Binding Globulin Associated with Insulin Resistance in Men with Nonalcoholic Fatty Liver Disease

Low Serum Sex Hormone-Binding Globulin Associated with Insulin Resistance in Men with Nonalcoholic Fatty Liver Disease

Iron and Advanced Glycation End Products: Emerging Role of Iron in Androgen Deficiency in Obesity

Increased serum ferritin levels are independently associated with carotid atherosclerosis in women

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