The association between the <i>miR-146a</i> rs2910164 C&amp;gt;G polymorphism and Kawasaki disease in a southern Chinese population

Zhang, Li; Che, Di; Wang, Yanfei; Rong, Xing; Pi, Lei; Xu, Yufen; Li, Wei; Huang, Ping; Chu, Maoping

doi:10.1042/bsr20180749

Cited by 10 publications

(13 citation statements)

References 29 publications

(28 reference statements)

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“…The statistical analysis procedures have been described previously. 29 3 | RESULTS Table 1 shows the demographic characteristics of KD cases and controls. Mean ± SD age was 29.12 ± 24.68 months (range 1-166 months) for KD patients and 23.14 ± 21.72 months (range 1-166 months) for controls.…”

Section: Discussionmentioning

confidence: 99%

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P2RY12:rs7637803 TT variant genotype increases coronary artery aneurysm risk in Kawasaki disease in a southern Chinese population

et al. 2019

The Journal of Gene Medicine

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Background Activated‐platelet increases the risk of thrombosis in Kawasaki disease (KD) patients with a coronary artery aneurysm (CAA). The ADP pathway is one of the platelet activation and aggregation pathways. The P2RY12 gene encodes the ADP receptor that is highly concentrated on platelets. However, few studies have reported on P2RY12 in relation to KD susceptibility with or without CAA. Methods We recruited 1335 healthy controls and 776 KD patients, including 103 with CAA, and selected five P2RY12 polymorphisms: rs9859538, rs1491974, rs7637803, rs6809699 and rs2046934. The present study focused on the relationship between the P2RY12 polymorphisms and KD with or without CAA. Results Among all of the selected polymorphisms, single‐locus analysis showed no significant association between the P2RY12 polymorphism and KD susceptibility. However, we found a significant relationship between rs7637803 and CAA risk in KD patients [CT versus CC: odds ratio (OR) = 0.41, 95% confidence interval (CI) = 0.22–0.75; p = 0.0041; TT versus CC: OR = 2.90, 95% CI = 1.12–7.46; p = 0.0276]. Stratification analysis by age in KD patients indicated that the rs7637803 TT genotype increased CAA formation risk among children aged (OR = 3.90, 95% CI = 1.42–10.69; p = 0.0081) and increased the onset risk of CAA in males (OR = 6.28, 95% CI = 2.01–19.65; p = 0.0016). The combined effect of the five selected P2RY12 risk genotypes with the KD patients compared to non‐mutated P2RY12 genotypes (score: 0) showed that patients with P2RY12 genotype polymorphisms (score: 1–5) had a significantly increased CAA risk (p = 0.0086). Stratification analysis for the severity of CAA found that the rs7637803 TT genotype reduced giant CAA (GCAA) risk (OR = 4.60, 95% CI = 1.70–12.41; p = 0.0026). Conclusions The results of the present study indicate that the P2RY12 rs7637803 genotype might be used as a biomarker to predict the occurrence of GCAA.

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Section: Discussionmentioning

confidence: 99%

“…The associations between the P2RY12 polymorphisms and KD were assessed with stratification by age, sex, CAA and GCAA presence. The statistical analysis procedures have been described previously …”

Section: Methodsmentioning

confidence: 99%

P2RY12:rs7637803 TT variant genotype increases coronary artery aneurysm risk in Kawasaki disease in a southern Chinese population

et al. 2019

The Journal of Gene Medicine

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“…Our previous study reported that miRNA-146a rs2910164 C>G may not be associated with Kawasaki disease susceptibility in children from South China. 18 We found that miRNA-137 rs1625579 T>G is associated with the onset of Kawasaki disease in the same population in children younger than 1 year old. 16 To our knowledge, this report is the first on the association of miRNA-196a2 rs11614913 T>C with Kawasaki disease susceptibility among children in South China.…”

Section: Discussionsmentioning

confidence: 67%

“…The control group was composed of 623 healthy Chinese children who went to the hospital for physical examination in the same period. [16][17][18] Peripheral venous blood was taken from each child to extract DNA.…”

Section: Study Subjectsmentioning

confidence: 99%

Association between miRNA‐196a2 rs11614913 T>C polymorphism and Kawasaki disease susceptibility in southern Chinese children

Qiu

Zeng

et al. 2019

Clinical Laboratory Analysis

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This is an open access article under the terms of the Creat ive Commo ns Attri butio n-NonCo mmercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. AbstractBackground: miRNAs play important roles in a variety of diseases. Thus, the association between miRNA-196a2 rs11614913 T>C polymorphism and Kawasaki disease susceptibility is still unknown. Methods:We included 532 children with Kawasaki disease and 623 healthy children from South China, and their DNA was extracted for genotyping by TaqMan methodology. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of association. Results: No significant associations were observed between the miRNA-196a2rs11614913 T>C polymorphisms and Kawasaki disease risk (TC vs TT: adjusted OR = 1.04, 95% CI = 0.79-1.37; CC vs TT: adjusted OR = 0.87, 95% CI = 0.63-1.21; dominant model: adjusted OR = 0.99, 95% CI = 0.76-1.27; and recessive model: adjusted OR = 0.85, 95% CI = 0.64-1.13). There was also no significant correlation found in stratified analyses. Conclusion:This study suggests that miRNA-196a2 rs11614913 T>C may not be associated with Kawasaki disease susceptibility in a southern Chinese population. Larger, multicenter studies are needed to confirm our conclusions. K E Y W O R D SKawasaki disease, miRNA-196a2, polymorphism, susceptibility 2 of 6 | WANG et Al.

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“…All participants recruited were unrelated Chinese Han individuals from southern China. A total of 623 healthy controls and 532 patients diagnosed with KD were recruited from January 2012 to January 2017 as we described previously . Two milliliters of fresh blood was collected from each participant, and 200 µL of each blood sample was employed to extract DNA.…”

Section: Methodsmentioning

confidence: 99%

Association between the miRNA‐149 rs2292832 T>C polymorphism and Kawasaki disease susceptibility in a southern Chinese population

Jiang

et al. 2019

Clinical Laboratory Analysis

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This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. AbstractBackground: Kawasaki disease (KD), which is characterized by vasculitis, is prone to occur in patients under 5 years of age, has an ambiguous etiology, and displays coronary artery lesions as the chief complication. Previous studies have linked miRNA-149 to cancers, and rs2292832 T>C is related to allergic diseases and inflammatory bowel disease, which both show immune system disorders and coronary artery disease. Therefore, we performed a study concentrating on the association between the miRNA-149 rs2292832 T>C polymorphism and KD susceptibility. Methods:The subjects enrolled were 532 children with KD and 623 controls. We used TaqMan real-time PCR to obtain the genotypes of the rs2292832 T>C polymorphism. Results:Ultimately, no significant association was found between the miRNA-149 rs2292832 T>C polymorphism and KD susceptibility, even in stratification analysis. Conclusion:Our results indicated that in southern Chinese patients, the miRNA-149 rs2292832 T>C polymorphism did not affect KD susceptibility, which needs to be further confirmed. K E Y W O R D S Kawasaki disease, miRNA-149, polymorphism S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section. How to cite this article: Li J, Wang J, Su X, et al. Association between the miRNA-149 rs2292832 T>C polymorphism and Kawasaki disease susceptibility in a southern Chinese population. J Clin Lab Anal. 2020;34:e23125. https ://doi.

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The association between the miR-146a rs2910164 C>G polymorphism and Kawasaki disease in a southern Chinese population

Cited by 10 publications

References 29 publications

P2RY12:rs7637803 TT variant genotype increases coronary artery aneurysm risk in Kawasaki disease in a southern Chinese population

P2RY12:rs7637803 TT variant genotype increases coronary artery aneurysm risk in Kawasaki disease in a southern Chinese population

Association between miRNA‐196a2 rs11614913 T>C polymorphism and Kawasaki disease susceptibility in southern Chinese children

Association between the miRNA‐149 rs2292832 T>C polymorphism and Kawasaki disease susceptibility in a southern Chinese population

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The association between the miR-146a rs2910164 C&gt;G polymorphism and Kawasaki disease in a southern Chinese population

Cited by 10 publications

References 29 publications

P2RY12:rs7637803 TT variant genotype increases coronary artery aneurysm risk in Kawasaki disease in a southern Chinese population

P2RY12:rs7637803 TT variant genotype increases coronary artery aneurysm risk in Kawasaki disease in a southern Chinese population

Association between miRNA‐196a2 rs11614913 T>C polymorphism and Kawasaki disease susceptibility in southern Chinese children

Association between the miRNA‐149 rs2292832 T>C polymorphism and Kawasaki disease susceptibility in a southern Chinese population

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The association between the miR-146a rs2910164 C>G polymorphism and Kawasaki disease in a southern Chinese population