The association between testosterone deficiency and nocturia: Insights from The National Health and Nutrition Examination Survey data set

Abstract

AimsTo examine the association between testosterone deficiency (TD) and nocturia in males, with specific attention to age and cardiovascular disease (CVD) comorbidity.MethodsThis cross‐sectional study utilized the National Health and Nutrition Examination Survey (NHANES) data from 2011 to 2016, assessing 6137 adult male participants. TD was defined by a serum total testosterone (TT) concentration less than 300 ng/dL. Nocturia was determined based on participants' responses to a standard NHANES question regarding the frequency of urination during the night.ResultsThe study observed a significant association between TD and nocturia (adjusted odds ratio [95% confidence interval] = 1.211 [1.060–1.384], p = 0.005). Moreover, a U‐shape pattern was noted in the relationship between serum TT concentration and the relative odds of nocturia. Subgroup analysis revealed a robust correlation between TD and nocturia in those over 60 years old, and those with hypertension, dyslipidemia, and CVDs.ConclusionOur findings suggest a positive correlation between TD and nocturia, particularly among elderly individuals with CVD. This association underscores the potential therapeutic significance of addressing TD in the management of nocturia. Furthermore, longitudinal studies are needed to establish a causal relationship between TD and nocturia.

Revisiting the nocturia‐testosterone deficiency nexus: A circadian perspective

“…To the Editor We read with interest the study by Kim et al on the association between testosterone deficiency (TD) and nocturia, leveraging insights from the National Health and Nutrition Examination Survey data set. 1 This study meticulously outlines how TD correlates significantly with nocturia, especially among older men and those with comorbid cardiovascular diseases (CVD), dyslipidemia, and hypertension. While Kim et al primarily consider TD as a contributing factor to nocturia and nocturnal polyuria, our perspective inversely suggests that nocturia, through disrupting sleep, may precipitate TD.…”