The Association Between Subclinical Hypothyroidism and Metabolic Syndrome as Defined by the ATP III Criteria

Eftekharzadeh, Anita; Khamseh, Mohammad E.; Farshchi, Amir; Malek, Mojtaba

doi:10.1089/met.2015.0065

Cited by 25 publications

(12 citation statements)

References 30 publications

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“…Observational studies concerning the association between SCH and MetS have shown contradictory results. In addition, two recent meta-analyses also failed to clarify this problem; one of them found a positive association [27], whereas no association was found in the other study [28]. CVD risk and mortality are increased in SCH [4, 5], particularly among subjects younger than 65 years and in those with a TSH concentration greater than or equal to 10 mIU/L.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome, Thyroid Function and Autoimmunity - The PORMETS Study

Raposo

Martins

Ferreira

et al. 2019

EMIDDT

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Background The prevalence of thyroid dysfunction and autoimmunity in the Portuguese population has not yet been estimated. However, the national prevalence of the metabolic syndrome remains high. The association of thyroid pathology with cardiovascular risk has been addressed but is still unclear. Our study aimed to evaluate the prevalence of thyroid dysfunction and autoimmunity and to assess the associations of thyroid-stimulating hormone and thyroid hormones and antibodies with metabolic syndrome, its components, and other possible determinants in a national sample. Material and methods The present study included a subsample of 486 randomly selected participants from a nationwide cross-sectional study sample of 4095 adults. A structured questionnaire was administered on past medical history and socio-demographic and behavioural characteristics. Blood pressure (BP) and anthropometric measurements were collected, and the serum lipid profile, glucose, insulin, hs-CRP, TSH, FT4, FT3 and thyroid antibodies were measured. Results In our sample, the prevalence of hypothyroidism, hyperthyroidism and undiagnosed dysfunction was 4.9%, 2.5% and 72.2%, respectively. Overall, the prevalence of positivity for the thyroid peroxidase and thyroglobulin antibodies was 11.9% and 15.1%, respectively. A positive association was found between free triiodothyronine and metabolic syndrome (OR: 2.019; 95% CI: 1.196, 3.410). Additionally, thyroid peroxidase antibodies had a negative association with metabolic syndrome (OR: 0.465; 95% CI: 0.236, 0.917) and its triglyceride component (OR: 0.321; 95% CI: 0.124, 0.836). Conclusion The prevalence of undiagnosed thyroid dysfunction and autoimmunity was high. Thyroid peroxidase antibodies were negatively associated with metabolic syndrome and its triglyceride component, whereas the free triiodothyronine level was positively associated with metabolic syndrome.

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Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome, Thyroid Function and Autoimmunity - The PORMETS Study

Raposo

Martins

Ferreira

et al. 2019

EMIDDT

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“…Another meta-analysis assessed the association between metabolic syndrome and SHypo by employing the Adult Treatment Panel III (ATP III) criteria for MetS. (341) Although this study did not report a significant difference in MetS prevalence between SHypo and euthyroid individuals (OR = 1.13, 95% CI 0.95-1.34), the prevalence of central obesity (OR = 1.43, 95% CI 1.04-1.96) was significantly higher in the SHypo group, and hypertriglyceridemia was prevalent in the female group with SHypo (341). There are reports on higher TSH levels in metabolic syndrome patients than in healthy ones, and high prevalence of metabolic syndrome in subjects with TSH level higher than normal when compared to those with normal TSH levels (177,342).…”

Section: Association Between Metabolic Syndrome and Thyroid Hormonmentioning

confidence: 99%

Thyroid Dysfunction and Diabetes Mellitus: Two Closely Associated Disorders

2019

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“…Two MAs34 35 have confirmed that SCH was not associated with MetS, and the AMSTAR scores were high. Three MAs29 45 47 have investigated the effect of SCH on cognitive function and shown that SCH was not significantly associated with cognitive impairment.…”

Section: Discussionmentioning

confidence: 93%

“…Among the 52 included eligible MAs, 4628–73 (46/52, 88.5%) were published in English, and the rest74–79 (6/52, 11.5%) were published in Chinese. The 52 included MAs contained 685 studies, with an average of 13.2 (range: 3–39) studies per article.…”

Section: Resultsmentioning

confidence: 99%

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Hypothyroidism and related diseases: a methodological quality assessment of meta-analysis

Tian¹,

Shao²,

Qin³

et al. 2019

BMJ Open

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ObjectivesThere is an increasing prevalence of hypothyroidism and there is a growing body of meta-analyses (MAs) on the association between hypothyroidism and other diseases. However, the methodological quality of the MAs significantly varies. Thus, this study aimed to evaluate and summarise data on the methodological quality of MAs on the associations between hypothyroidism and other diseases using the Assessment of Multiple Systematic Reviews (AMSTAR) scale, providing suggestions for clinical decision-making processes.DesignTo assess the methodological quality of MAs using the AMSTAR scale.Data sourcesA systematic literature search was performed in PubMed, EMBASE, the Cochrane Library, web of science and Chinese Biomedicine Literature Database.Eligibility criteriaWe included MAs that had assessed the association between hypothyroidism and other diseases in humans and that had full texts regardless of the publication status. No restriction applied on language or date.Data extraction and synthesisTwo reviewers independently screened the titles and abstracts of all searched literature to acquire potentially eligible publications. The full texts of possible eligible publications were downloaded and assessed. Inconsistent comments were resolved through discussions with a third reviewer.Results52 studies were included. The average AMSTAR score of the included articles was 8.6 (range: 5–10), and those of English and Chinese MAs were 8.8 and 7.0, respectively. A total of 52 MAs were evaluated, and 19 (36.5%) and 33 (63.5%) of these MAs were of moderate and high quality, respectively. None of the MAs were of low quality. Only two MAs had an a priori design. Items 3, 5 and 9 had the highest compliance (50/52, 96.2%), and aside from item 1, items 7 and 8 had the lowest compliance (33/52,63.5%). According to the results of these MAs, hypothyroidism was significantly associated with cardiovascular diseases, metabolic diseases, neuropsychiatric disorders, breast cancer and pregnancy outcome.ConclusionsThe methodological quality of the included MAs on the association between hypothyroidism and other diseases was moderate to high. MAs with high qualities confirmed that hypothyroidism was significantly associated with cardiovascular diseases, metabolic syndrome, preterm birth and neonatal outcomes. Consideration of scientific quality when formulating conclusions should be made explicit and more attention should be paid to improving the methodological quality of MAs, and increasing their applicability for clinical decision-making.

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The Association Between Subclinical Hypothyroidism and Metabolic Syndrome as Defined by the ATP III Criteria

Cited by 25 publications

References 30 publications

Metabolic Syndrome, Thyroid Function and Autoimmunity - The PORMETS Study

Metabolic Syndrome, Thyroid Function and Autoimmunity - The PORMETS Study

Thyroid Dysfunction and Diabetes Mellitus: Two Closely Associated Disorders

Hypothyroidism and related diseases: a methodological quality assessment of meta-analysis

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