The association between sleep spindles and cognitive function in middle-aged and older men from a community-based cohort study

Parker, J; Appleton, Sarah; Adams, Robert; Melaku, Yohannes Adama; D'Rozario, Angela L; Wittert, Gary; Martin, Sean; Catcheside, Peter; Lechat, Bastien; Teare, A; Toson, Barbara; Vakulin, Andrew

doi:10.1016/j.sleh.2023.03.007

Cited by 1 publication

(3 citation statements)

References 44 publications

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“… 50 Additionally, in our study, we observed that a higher density of slow sleep spindles was significantly associated with better performance in the TMT-A and TMT-B test among patients. In contrast to a community-based cohort study in middle-aged and older adults, 24 we did not observed an association between fast sleep spindle density and TMT-B test during N3 sleep time; instead, we observed that longer sleep spindle duration was significantly associated with better TMT-B performance in this period.…”

Section: Discussioncontrasting

confidence: 99%

“… 23 Furthermore, the associations between sleep spindle metrics and functional outcomes was explored in large population-based sample of aging men, and results showed that higher fast spindle density during N3 sleep time was associated with worse executive performance. 24 These observations supported the utility of sleep spindle metrics as useful executive function markers in older OSA. Cognitive impairment in OSA patients presents at a younger age; however, our understanding of how this relationship may manifest in the younger OSA patient population is limited.…”

Section: Introductionsupporting

confidence: 53%

“…35 These results strongly support previous findings in the field that altered sleep spindle morphology (lower spindle frequency, higher amplitude and density) could predict cognitive performance. 15,18,24,36,37 In addition, our study makes a novel contribution by identifying the duration of the sleep spindle both during N2 and N3 sleep times as a significant marker of executive function.…”

Section: Discussionmentioning

confidence: 98%

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Associations Between Sleep Spindle Metrics, Age, Education and Executive Function in Young Adult and Middle-Aged Patients with Obstructive Sleep Apnea

Sui,

Li,

Shi

et al. 2024

NSS

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Purpose This study aimed to investigate the association between sleep spindle metrics and executive function in individuals with obstructive sleep apnea (OSA). Furthermore, we examined the association of age and education on executive function. Patients and Methods A total of 230 (40.90 ± 8.83 years, F/M = 45/185) participants were enrolled. Overnight electroencephalogram (C3-M2) recording detected sleep spindles by a novel U-Net-type neural network that integrates temporal information with time-frequency images. Sleep spindle metrics, including frequency (Hz), overall density (events/min), fast density (events/min), slow density (events/min), duration (sec) and amplitude (µV), were measured. Executive function was assessed using standardized neuropsychological tests. Associations between sleep spindle metrics, executive function, and demographic factors were analyzed using multivariate linear regression. Results In fully adjusted linear regression models, higher overall sleep spindle density (TMT-A, B=−1.279, p=0.009; TMT-B, B=−1.813, p=0.008), fast sleep spindle density (TMT-A, B=−1.542, p=0.048; TMT-B, B=−2.187, p=0.036) and slow sleep spindle density (TMT-A, B=−1.731, p=0.037; TMT-B, B=−2.449, p=0.034) were associated with better executive function. And the sleep spindle duration both during N2 sleep time (TMT-A, B=−13.932, p=0.027; TMT-B, B=−19.001, p=0.034) and N3 sleep time (TMT-B, B=−29.916, p=0.009; Stroop-incongruous, B=−21.303, p=0.035) was independently associated with better executive function in this population. Additionally, age and education were found to be highly associated with executive function. Conclusion Specific sleep spindle metrics, higher overall density, fast density and slow density during N2 sleep time, and longer duration during N2 and N3 sleep time, are independent and sensitive indicators of better executive function in young adult and middle-aged patients with OSA. Further research is needed to explore the underlying mechanisms and clinical implications of these findings.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionsupporting

confidence: 53%