The association between sleep microarchitecture and cognitive function in middle-aged and older men: a community-based cohort study

Parker, J; Appleton, Sarah; Melaku, Yohannes Adama; D'Rozario, Angela L; Wittert, Gary; Martin, Sean; Toson, Barbara; Catcheside, Peter; Lechat, Bastien; Teare, A; Adams, Robert; Vakulin, Andrew

doi:10.5664/jcsm.9934

Cited by 9 publications

(13 citation statements)

References 63 publications

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“…In addition to the aforementioned EEG biomarkers, qEEG analyses of spectral power in different frequencies may demonstrate a relationship with cognition, especially within REM sleep. Recent studies in aging community populations have shown that REM theta power (in the 5–7‐Hz frequency bands) was negatively associated with worse cognitive scores on the Trail‐Making Tests (Parker et al, 2022), while NREM theta power was associated with MCI in aging (Taillard et al, 2019). Higher REM theta power was also associated with progression to dementia in patients with PD (Latreille et al, 2016).…”

Section: Eeg Measures Of Sleep Microstructure In Osamentioning

confidence: 99%

Sleep electroencephalography biomarkers of cognition in obstructive sleep apnea

Gagnon

Kamińska

2023

Journal of Sleep Research

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SummaryObstructive sleep apnea has been associated with cognitive impairment and may be linked to disorders of cognitive function. These associations may be a result of intermittent hypoxaemia, sleep fragmentation and changes in sleep microstructure in obstructive sleep apnea. Current clinical metrics of obstructive sleep apnea, such as the apnea–hypopnea index, are poor predictors of cognitive outcomes in obstructive sleep apnea. Sleep microstructure features, which can be identified on sleep electroencephalography of traditional overnight polysomnography, are increasingly being characterized in obstructive sleep apnea and may better predict cognitive outcomes. Here, we summarize the literature on several major sleep electroencephalography features (slow‐wave activity, sleep spindles, K‐complexes, cyclic alternating patterns, rapid eye movement sleep quantitative electroencephalography, odds ratio product) identified in obstructive sleep apnea. We will review the associations between these sleep electroencephalography features and cognition in obstructive sleep apnea, and examine how treatment of obstructive sleep apnea affects these associations. Lastly, evolving technologies in sleep electroencephalography analyses will also be discussed (e.g. high‐density electroencephalography, machine learning) as potential predictors of cognitive function in obstructive sleep apnea.

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Section: Eeg Measures Of Sleep Microstructure In Osamentioning

confidence: 99%

Sleep electroencephalography biomarkers of cognition in obstructive sleep apnea

Gagnon

Kamińska

2023

Journal of Sleep Research

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“… 17 , 18 Slow theta waves are linked to subcortical brain regions involved in affective processes, whereas fast beta activity that is argued to reside at the thalamo-cortical and cortico-cortical level is associated with cognitive control processes. 19 Since OSA has been reported to be associated with cognitive impairments, 20 , 21 it is unknown whether the cognition-related brain damage can be indicated by EEG and there is no relevant study on the characteristics of TBR in patients with OSA.…”

Section: Introductionmentioning

confidence: 99%

Electroencephalography Theta/Beta Ratio Decreases in Patients with Severe Obstructive Sleep Apnea

Li¹,

You²,

Yin³

et al. 2022

NSS

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Purpose Accumulating evidence suggests that theta/beta ratio (TBR), an electroencephalographic (EEG) frequency band parameter, might serve as an objective marker of executive cognitive control in healthy adults. Obstructive sleep apnea (OSA) has a detrimental impact on patients’ behavior and cognitive performance while whether TBR is different in OSA population has not been reported. This study aimed to explore the difference in relative EEG spectral power and TBR during sleep between patients with severe OSA and non-OSA groups. Patients and Methods 142 participants with in-laboratory nocturnal PSG recording were included, among which 100 participants suffered severe OSA (apnea hypopnea index, AHI > 30 events/hour; OSA group) and 42 participants had no OSA (AHI ≤ 5 events/h; control group). The fast Fourier transformation was used to compute the EEG power spectrum for total sleep duration within contiguous 30-second epochs of sleep. The demographic and polysomnographic characteristics, relative EEG spectral power and TBR of the two groups were compared. Results It was found that the beta band power during NREM sleep and total sleep was significantly higher in the OSA group than controls (p < 0.001, p = 0.012, respectively), and the theta band power during NREM sleep and total sleep was significantly lower in the OSA group than controls (p = 0.019, p = 0.014, respectively). TBR during NREM sleep, REM sleep and total sleep was significantly lower in the OSA group compared to the control group (p < 0.001 for NREM sleep and total sleep, p = 0.015 for REM sleep). TBR was negatively correlated with AHI during NREM sleep (r=−0.324, p < 0.001) and total sleep (r=−0. 312, p < 0.001). Conclusion TBR was significantly decreased in severe OSA patients compared to the controls, which was attributed to both increased beta power and decreased theta power. TBR may be a stable EEG-biomarker of OSA patients, which may accurately and reliably identify phenotype of patients.

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“…As described previously (Parker et al, 2022;Parker, Appleton, et al, 2021; (www.qsleep.com.au), where performance was consistently within two quartiles of national assessments. Acceptable sleep studies were those with ≥3.5 h of sleep and ≥5.5 h of totalrecorded study time with good respiratory and EEG signal quality.…”

Section: Baseline Sleep Study Assessmentmentioning

confidence: 58%

“…As described previously (Parker et al, 2022; Parker, Appleton, et al, 2021; Parker, Melaku, et al, 2021), participants underwent home‐based eight‐channel ambulatory PSG (Embletta X100, Embla Systems, Broomfield, Colorado, USA), which recorded electrical brain activity (electroencephalography [EEG], F4‐M1) and left electro‐oculography with 12‐bit signal resolution, 200 Hz sampling rate, and band‐pass filters (0.3–35 Hz) together with submental electromyography, nasal cannula pressure, thoracic and abdominal motion, finger pulse oximetry, and body position. Trained staff set‐up and attached the PSG equipment and obtained anthropometric measures (height, weight, and body mass index [BMI, kg/m 2 ]).…”

Section: Methodsmentioning

confidence: 99%

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Associations of baseline obstructive sleep apnea and sleep macroarchitecture with cognitive function after 8 years in middle‐aged and older men from a community‐based cohort study

Parker,

Vakulin,

Naik

et al. 2023

Journal of Sleep Research

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SummaryPrevious prospective studies examining associations of obstructive sleep apnea and sleep macroarchitecture with future cognitive function recruited older participants, many demonstrating baseline cognitive impairment. This study examined obstructive sleep apnea and sleep macroarchitecture predictors of visual attention, processing speed, and executive function after 8 years among younger community‐dwelling men. Florey Adelaide Male Ageing Study participants (n = 477) underwent home‐based polysomnography, with 157 completing Trail‐Making Tests A and B and the Mini‐Mental State Examination. Associations of obstructive sleep apnea (apnea–hypopnea index, oxygen desaturation index, and hypoxic burden index) and sleep macroarchitecture (sleep stage percentages and total sleep time) parameters with future cognitive function were examined using regression models adjusted for baseline demographic, biomedical, and behavioural factors, and cognitive task performance. The mean (standard deviation) age of the men at baseline was 58.9 (8.9) years, with severe obstructive sleep apnea (apnea–hypopnea index ≥30 events/h) in 9.6%. The median (interquartile range) follow‐up was 8.3 (7.9–8.6) years. A minority of men (14.6%) were cognitively impaired at baseline (Mini‐Mental State Examination score <28/30). A higher percentage of light sleep was associated with better Trail‐Making Test A performance (B = −0.04, 95% confidence interval [CI] −0.06, −0.01; p = 0.003), whereas higher mean oxygen saturation was associated with worse performance (B = 0.11, 95% CI 0.02, 0.19; p = 0.012). While obstructive sleep apnea and sleep macroarchitecture might predict cognitive decline, future studies should consider arousal events and non‐routine hypoxaemia measures, which may show associations with cognitive decline.

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The association between sleep microarchitecture and cognitive function in middle-aged and older men: a community-based cohort study

Cited by 9 publications

References 63 publications

Sleep electroencephalography biomarkers of cognition in obstructive sleep apnea

Sleep electroencephalography biomarkers of cognition in obstructive sleep apnea

Electroencephalography Theta/Beta Ratio Decreases in Patients with Severe Obstructive Sleep Apnea

Associations of baseline obstructive sleep apnea and sleep macroarchitecture with cognitive function after 8 years in middle‐aged and older men from a community‐based cohort study

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