The association between sleep architecture, quality of life, and hypertension in patients with obstructive sleep apnea

Chen, Lixia; Chun-jie, Bai; Zheng, Yanan; Wei, Lai; Han, Cuihua; Yuan, Na; Ji, Daihong

doi:10.1007/s11325-022-02589-z

Cited by 5 publications

(5 citation statements)

References 52 publications

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“…This suggests that the risk of developing hypertension increases with AHI. Sleep in patients with OSA is highly fragmented, with a higher proportion of light sleep; the proportion of slow wave sleep (SWS) is significantly decreased, and SWS stage is accompanied by lower sympathetic nervous activity and higher parasympathetic nerve activity ( 3 , 21 ). Experimental inhibition of human SWS can significantly reduce the drop in blood pressure at night, that is, the increase in blood pressure at night; a decrease in the proportion of SWS is considered a sign of elevated blood pressure ( 22 ).…”

Section: Discussionmentioning

confidence: 99%

“…OSA can cause a series of pathophysiological results such as chronic intermittent hypoxia, oxidative stress and inflammatory response, increased negative pressure in the pleural cavity, and increased sympathetic nerve activity ( 2 ). Patients with OSA may present with a variety of symptoms, including habitual snoring, fatigue, poor sleep quality, excessive daytime sleepiness (EDS), memory loss, headaches, and psychological disturbances ( 3 ). Many studies have confirmed that untreated OSA can damage multiple systems and organs and cause a variety of complications, including cardiovascular diseases, ischemic stroke, metabolic-related diseases, and neuropsychiatric complications ( 4 – 7 ).…”

Section: Introductionmentioning

confidence: 99%

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Symptom and comorbidity burden in hypertensive patients with obstructive sleep apnea

Tao,

Dong,

et al. 2024

Front. Endocrinol.

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BackgroundObstructive sleep apnea (OSA) is an important but frequently overlooked risk factor for hypertension (HTN). The prevalence of hypertension is high in patients with OSA, but the differences in clinical symptoms and comorbidities between patients with OSA with hypertension and those with normal blood pressure have not been fully defined.MethodsThis study retrospectively analyzed OSA patients diagnosed for the first time in Lihuili Hospital Affiliated to Ningbo University from 2016 to 2020. Patients were divided into an OSA group with hypertension and an OSA group without hypertension. The sociodemographic information, clinical symptoms, comorbidities, and polysomnography results of the two groups were compared. The independent risk factors associated with hypertension in patients with OSA were explored.ResultsA total of 1108 patients with OSA initially diagnosed were included in the study, including 387 with hypertension and 721 without. Compared with OSA patients without hypertension, OSA patients with hypertension were older; had a higher body mass index (BMI) and Epworth sleepiness score (ESS); a higher incidence of nocturia; and a higher proportion of diabetes mellitus, coronary heart disease, and cerebrovascular disease. Multivariate analysis showed age (odds ratio [OR]:1.06, 95% confidence interval [CI]:1.04-1.08), BMI (OR:1.17, 95% CI:1.11-1.23), ESS score (OR:0.97, 95%CI: 0.94-1.00) and nocturia symptoms (OR:1.64, 95% CI:1.19-2.27) was independently associated with hypertension in OSA patients, and comorbid diabetes (OR: 3.86, 95% CI: 2.31-6.45), coronary heart disease (OR: 1.90, 95% CI:1.15-3.16), and ischemic stroke (OR: 3.69,95% CI:1.31-10.40) was independently associated with hypertension in OSA patients.ConclusionCompared to OSA patients with normal blood pressure, OSA patients with hypertension had more significant daytime sleepiness, more frequent nocturnal urination, and a higher risk of diabetes, coronary heart disease, and cerebrovascular disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Symptom and comorbidity burden in hypertensive patients with obstructive sleep apnea

Tao,

Dong,

et al. 2024

Front. Endocrinol.

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“…CPAP in this case prevents this collapse/partial collapse and prevents the manifestations of the disease. Leading to a better quality of sleep hence, decreasing day time sleepiness and fatigue hence a better quality of life [15].…”

Section: Discussionmentioning

confidence: 99%

Improvement in Hypertension Symptoms and Measurement Readings of Blood Pressure with Non-Invasive Positive Pressure Ventilation in Hypertensive Patients having Obstructive Sleep Apnea/Hypopnea Syndrome (OSAHS)

Rahul¹,

Avetisyan²,

Aakash³

2022

Int J Clin Cardiol

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Objective: Hypertension is a common comorbidity in obstructive sleep apnea/hypopnea syndrome (OSAHS). OSAHS can raise blood pressures to pre-hypertensive and hypertensive ranges, increase the prevalence of "nondipping" overnight blood pressure patterns, and increase the risk of resistant hypertension. The gold standard treatment for OSAHS is non-invasive ventilation through CPAP. The aim of this study is to investigate the effects of noninvasive positive pressure ventilation/CPAP on symptoms of hypertension and the blood pressure measurements in hypertensive patients having OSAHS. Patients and methods:We conducted a retrospective study among 10 male patients with OSAHS (group 1) and comorbid hypertension and 10 control subjects (group 2) with the same disease, the first 10 patients received non-invasive positive pressure ventilation therapy while the controls did not. The data was collected during duration of 2 months (1 month -before treatment and 1 month -after treatment. The AHI (apnea-hypopnea index)/RDI (respiratory disturbance index) and 6 times per day blood pressures measurements, keeping a close watch on general hypertension symptoms through a customised questionnaire.Results: When both the group's data were compared it showed a considerable decline in;

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“…Ineffective sleep cannot be regarded only in terms of daytime sleepiness and lack of concentration during the day. The systemic complications involve the development of hypertension and as a result increase overall cardiovascular risk and reduce healthy life expectancy [47,48]. The formidable challenge is aggravated by the fact that symptoms accompanying hypertension such as headaches and tinnitus can equally be the symptoms of SB [49,50].…”

Section: Sleep Bruxism As a Behaviormentioning

confidence: 99%

Inflammatory Markers and Sleep Architecture in Sleep Bruxism—A Case-Control Study

Fulek,

Wieckiewicz,

Szymanska-Chabowska

et al. 2024

JCM

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Background: Sleep bruxism (SB) is a common sleep-related movement behavior with a multifaceted etiology and a deficiently understood pathophysiology. A recent hypothesis suggests a link between SB and systemic inflammation. The scope of the study was to determine whether bruxers have altered sleep structure and different levels of inflammatory parameters compared to nonbruxers. Methods: A total of 83 adults underwent full-night polysomnography. The polysomnograms were evaluated using the American Academy of Sleep Medicine (AASM) guidelines. Then, the blood samples were obtained from the participants by venipuncture and the analyses were performed. The study group was divided based on bruxism episode index (BEI) into two groups: BEI ≤ 4 and BEI > 4. Results: In comparison with nonbruxers, the oxygen desaturation index (ODI) was significantly higher in severe bruxers (7.5 ± 11.08 vs. 3.33 ± 5.75, p < 0.005), as well as the arousal parameters (7.77 ± 4.68 vs. 4.03 ± 2.97, p < 0.001), and the mean oxygen desaturation (3.49 ± 0.69 vs. 3.01 ± 0.67, p < 0.05). Moreover, the differences in sleep architecture and deprivation of the deep sleep phase were observed, the non-REM sleep stage 3 was significantly shorter in severe bruxers (p < 0.03). Differences were also noted in non-REM sleep stage 1 and REM sleep phase. In the investigated group, there were no statistical differences in inflammatory cytokines levels between bruxers and nonbruxers. Conclusions: Sleep bruxism is associated with sleep structure alterations and may be associated with deep sleep phase deprivation. The inflammatory markers are not linearly correlated with the severity of sleep bruxism expressed as BEI.

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The association between sleep architecture, quality of life, and hypertension in patients with obstructive sleep apnea

Cited by 5 publications

References 52 publications

Symptom and comorbidity burden in hypertensive patients with obstructive sleep apnea

Symptom and comorbidity burden in hypertensive patients with obstructive sleep apnea

Improvement in Hypertension Symptoms and Measurement Readings of Blood Pressure with Non-Invasive Positive Pressure Ventilation in Hypertensive Patients having Obstructive Sleep Apnea/Hypopnea Syndrome (OSAHS)

Inflammatory Markers and Sleep Architecture in Sleep Bruxism—A Case-Control Study

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