The association between shift work and hyperuricemia in steelmaking male workers

Abstract

ObjectivesThe aim of this study was to examine the association between shift work and hyperuricemia among steel company workers.MethodsWe examined 1,029 male workers at a Korean steel company between June 6 and June 28, 2013. We conducted anthropometric measurements, questionnaire surveys, and blood tests. Hyperuricemia was defined as a serum uric acid concentration of ≥7.0 mg/dL. Logistic regression analyses were performed. In the full model, analysis was adjusted for covariates including age, body mass index, lifestyle factors, and comorbidities. The odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for all models.ResultsThe participants included 276 daytime workers and 753 shift workers. Among daytime workers, 72 (26.1%) individuals had hyperuricemia, as did 282 (37.5%) individuals among shift workers (p <0.001). There was a statistically significant association between shift work and hyperuricemia. In the unadjusted model, the OR of shift work was 1.70 (95% CI 1.25-2.31) for hyperuricemia. In the full model, the OR of shift work was also statistically significant after adjustment for covariates (OR 1.41, 95% CI 1.02-1.96).ConclusionsAmong male steel workers, a significant association between shift work and hyperuricemia was observed.

Habitually Late Bedtime is Associated With Elevated Serum Uric Acid and Monosodium Urate Monohydrate Deposition in Patients With Gout: A Case Control Study

“…A late bedtime can increase circulating uric acid levels. There is a positive relationship between bedtime and urate levels in long-term shift workers, who have elevated urate levels (3,9). In this study, we found that patients with gout also had elevated urate levels.…”

“…Sleep quality, duration, and bedtime are closely related to metabolic diseases such as hyperuricemia, diabetes, hypertension, and dyslipidaemia (4,5). For example, rotating shift workers often have elevated urate levels (6)(7)(8)(9). Qian (10) also found a signi cant association between bedtime and serum metabolites, such as uric acid and adenosine.…”

Association of hyperuricemia with metabolic syndrome among university workers: sex and occupational differences

“…Currently, there are few studies that determined the prevalence of hyperuricemia among workers in certain occupations. Oh et al,15 reported a significant positive association between shift work and hyperuricemia.…”

“…Given the close association between MetS and hyperuricemia, it is important to explore this relationship among workers as only few studies have reported the effects of occupational factors on plasma UA. Oh, et al,15 reported a significant association between shift work and hyperuricemia among Korean steelmaking male workers. In China, available evidence on the prevalence of hyperuricemia and its relationship with MetS focus on the general population16 or patients, with limited data on workers.…”

Hiperuricemia y menor actividad física en trabajadores a turnos: estudio transversal en una industria química española

“…Tanto el SMet como otros factores de riesgo cardiovascular han sido estudiados en relación al trabajo a turnos, definido por la Organización Internacional del Trabajo (OIT) como "todo trabajo que se realice durante un período mínimo de siete horas consecutivas, que comprenda el intervalo entre medianoche y las cinco de la mañana y que será determinado por la autoridad competente previa consulta con las organizaciones empresariales y de trabajadores o por medio de convenios colectivos" (9) . Esta definición da pie a que diferentes instituciones a nivel nacional emitan las suyas propias (10,11,12) y a que puedan encontrarse multitud de éstas en las investigaciones (6,13) . Las distintas definiciones del trabajo a turnos, las características propias de los sectores profesionales que realizan turnos (por ejemplo, el sanitario frente al químico), los distintos tipos de turnos, la alternancia entre el trabajo diurno y nocturno, el sentido de rotación, un número bajo de años acumulados a turnos, así como las diferencias en los componentes que han de valorarse en el diagnóstico del SMet, hacen que las conclusiones de los estudios sean, a menudo, opuestas.…”