The Association Between Shift Work and Immunological Biomarkers in Nurses

Bjorvatn, Bjørn; Axelsson, John; Pallesen, Ståle; Waage, Siri; Vedaa, Øystein; Blytt, Kjersti Marie; Buchvold, Hogne Vikanes; Moen, Bente E.; Thun, Eirunn

doi:10.3389/fpubh.2020.00415

Cited by 21 publications

(13 citation statements)

References 23 publications

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“…Targeting the Ros-HIF-1 axis may enable the treatment of obstructive sleep apnea-related cardiovascular complications ( Belaidi et al, 2016 ). In addition, the study showed that nurses with short sleep duration and poor sleep quality had elevated interferon gamma levels ( Bjorvatn et al, 2020 ). Excessive secretion of interferon-gamma in the periphery and the brain triggers inflammatory cascades involved in aging and aging-related medical and psychiatric disorders ( Oxenkrug, 2011 ).…”

Section: Discussionmentioning

confidence: 99%

B serum proteome profiles revealed dysregulated proteins and mechanisms associated with insomnia patients: A preliminary study

Liu

Wang

Zhang

et al. 2022

Front. Integr. Neurosci.

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BackgroundInsomnia is a clinical problem of significant public health importance; however, the underlying pathogenesis of this disorder is not comprehensively understood.MethodsTo identify potential treatment targets and unfold one of the gaps that were involved in insomnia pathological mechanisms, we employed a tandem mass tag-based (TMT) quantitative proteomics technology to detect differentially expressed proteins (DEPs) in serum from patients with insomnia and controls. DEPs were further analyzed by bioinformatics platforms. In addition, parallel reaction monitoring (PRM) was used to verify the TMT results.ResultsPatients with insomnia had poorer sleep quality compared with healthy controls. A total of 106 DEPs were identified among patients with insomnia and controls. They were mainly enriched in immune and inflammation-related biological functions and signaling pathways. Using the protein–protein interaction network, we screened the 10 most connected proteins as key DEPs. We predicted that four key DEPs were subject to targeted regulation by natural compounds of herbs. Eight key DEPs were validated using PRM in an additional 15 patients with insomnia and 15 controls, and the results also supported the experimental findings.ConclusionWe identified aberrantly expressed proteins in insomnia that may be involved in the immune-inflammatory response. The 10 key DEPs screened may be potential targets for insomnia, especially FN1, EGF, HP, and IGF1. The results of this study will broaden our understanding of the pathological mechanisms of insomnia and provide more possibilities for pharmacotherapy.

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Section: Discussionmentioning

confidence: 99%

B serum proteome profiles revealed dysregulated proteins and mechanisms associated with insomnia patients: A preliminary study

Liu

Wang

Zhang

et al. 2022

Front. Integr. Neurosci.

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“…A recent study showed that shift work influenced some immunological biomarkers ( 33 ). Thus, we hypothesized that hsCRP is also associated with shift work; however, we found no significant association between shift work and elevated hsCRP levels.…”

Section: Discussionmentioning

confidence: 99%

Effect of long work hours and shift work on high-sensitivity C-reactive protein levels among Korean workers

Lee

Kang²,

Choi³

2020

Scand J Work Environ Health

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Objective: We aimed to investigate the association between low-grade inflammation as indicated by high-sensitivity C-reactive protein (hsCRP) level and organizational factors, such as work hours and shift work. Methods: We evaluated 7470 young and middle-aged workers who participated in the Korea National Health and Nutrition Examination Surveys from 2015–2018. Work hours were determined from self-reported questionnaires. Shift work was defined as a non-daytime fixed work schedule. An interaction effect between shift work and long work hours on the hsCRP level was estimated using relative excess risk due to interaction (RERI) and attributable proportion (AP) with 95% confidence intervals (CI). Results: Increased hsCRP levels were prevalent in 25.2% of the study population. There was a significant association between long work hours and increased hsCRP, especially among middle-aged men [odds ratio (OR) 1.50 (95% CI 1.20–1.87) for moderately increased hsCRP and OR 1.62 (95% CI 1.14–2.30) for highly increased hsCRP]. There was a significant interaction effect between long work hours and shift work on increased hsCRP among middle-aged workers. The RERI were 0.03 (95% CI 0.02–0.04) and 0.56 (95% CI 0.45–0.68) among middle-aged men and women, respectively. The AP were 0.02 (95% CI 0.01–0.03) and 0.36 (95% CI 0.31–0.40) among middle-aged men and women, respectively. Conclusions: There was no significant association between shift work and the level of hsCRP. Long work hours were related to low-grade inflammatory processes, but only in middle-aged workers. There was an interaction effect between long work hours and shift work for increased hsCRP, especially in middle-aged women.

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“…The serum levels of AST, ALT, hs-CRP, and uric acid were measured using an automated clinical chemistry analyzer (FUJI DRI-CHEM 4000i). The serum levels of ferritin, IL-8, IFN-γ, IL-6, and TNF-α 16 , 29 , 30 were measured using enzyme-linked immunosorbent assay (Biosense Laboratories, Norway). Ferritin levels were measured using a human ferritin enzyme immunoassay test kit (IBL-Hamburg kit, Germany) according to the manufacturer’s instructions.…”

Section: Methodsmentioning

confidence: 99%

Relationship between serum 25 hydroxyvitamin D (25(OH)D) levels and mental health in shift female nurses

Tang

Yan

et al. 2022

Sci Rep

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The nurses work long hours and in various shifts, and often accompanied by depression, fatigue, and sleep disorders. Many studies have found that 25 hydroxyvitamin D (25(OH)D) is related to mental health. We aimed to investigate the relationship between depression, sleep problems, fatigue, and serum 25(OH)D levels in shift nurses. We recruited 34 day-shift, 30 evening-shift and 31 night-shift nurses. The Beck Depression Inventory II (BDI-II), Numerical Rating Scale and General Sleep Disturbance Scale to evaluate the levels of depression, sleep problems, fatigue. Blood samples (20 ml) were collected under a fasting state to determine basic biochemistry and inflammatory parameters. In central of Taiwan, approximately 96.1% of shift nurses had deficient (< 20 ng/ml) (45 females and 1 male) and inadequate (20–29 ng/ml) (39 females and 2 male) 25(OH)D levels. Approximately 84.2% of shift nurses experienced fatigue. In sleep disturbance, night-shift nurses experienced significantly more severe sleep disturbance than day-shift and evening-shift nurses. However, no significant correlation was observed between 25(OH)D levels and mental health when the 25(OH)D level was categorized. 25(OH)D deficiency, sleep disturbance, depression, and fatigue were common in shift female nurses, but it was not possible to demonstrate the impact of 25(OH)D deficiency on the mental health of shift nurses in Taiwan.

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The Association Between Shift Work and Immunological Biomarkers in Nurses

Cited by 21 publications

References 23 publications

B serum proteome profiles revealed dysregulated proteins and mechanisms associated with insomnia patients: A preliminary study

B serum proteome profiles revealed dysregulated proteins and mechanisms associated with insomnia patients: A preliminary study

Effect of long work hours and shift work on high-sensitivity C-reactive protein levels among Korean workers

Relationship between serum 25 hydroxyvitamin D (25(OH)D) levels and mental health in shift female nurses

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