The association between sexual dysfunction and metabolic syndrome among Turkish postmenopausal women

Yoldemir, Tevfik; Garibova, N; Atasayan, Kemal

doi:10.1080/13697137.2019.1580256

Cited by 9 publications

(3 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, women's sexual response cycle is also a complex process influenced by multiple factors, including vascular, nervous, hormonal, and psychogenic factors. Any disruption in these factors can contribute to female sexual dysfunction (FSD) [ 9 ]. Additionally, certain treatments for these conditions, such as the use of certain anti-hypertensive drugs or antidepressants, can have negative effects on sexual performance [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The global prevalence of sexual dysfunction in obese and overweight women: a systematic review and meta-analysis

et al. 2023

View full text Add to dashboard Cite

Background Obesity is a pressing public health risk issue worldwide. Women, in particular, face a higher risk of obesity. Recent research has highlighted the association between obesity and female sexual dysfunction. Therefore, the objective of this study is to investigate the global prevalence of sexual dysfunction in obese and overweight women through a systematic review and meta-analysis. Methods In this study, a systematic search was conducted across electronic databases, including PubMed, Scopus, Web of Science, Embase, ScienceDirect, and Google Scholar. The search aimed to identify studies published between December 2000 and August 2022 that reported metabolic syndrome's impact on female sexual dysfunction. Results The review included nine studies with a sample size of 1508 obese women. The I2 heterogeneity index indicated high heterogeneity (I2: 97.5). As a result, the random effects method was used to analyze the data. Based on this meta-analysis, the prevalence of sexual dysfunction in women with obesity was reported as 49.7% (95%CI: 35.8–63.5). Furthermore, the review comprised five studies involving 1411 overweight women. The I2 heterogeneity test demonstrated high heterogeneity (I2: 96.6). Consequently, the random effects model was used to analyze the results. According to the meta-analysis, the prevalence of sexual dysfunction in overweight women was 26.9% (95% CI: 13.5–46.5). Conclusion Based on the results of this study, it has been reported that being overweight and particularly obese is an important factor affecting women's sexual dysfunction. Therefore, health policymakers must acknowledge the significance of this issue in order to raise awareness in society about its detrimental effect on the female population.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Sexual dysfunction refers to any condition that hinders a person's ability to derive satisfaction from sexual activity [ 9 ]. In particular, female sexual dysfunction (FSD) is a complex disorder with multi-faceted causes rooted in biological and psychosocial factors [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

The global prevalence of sexual dysfunction in obese and overweight women: a systematic review and meta-analysis

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Premature ovarian failure (POF) is an ovarian dysfunction with cessation of menstruation before 40 years of age [ 1 ]. POF probably occurs when the number of ovarian follicles is exhausted before the typical age of physiological menopause [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of action of Zishen Yutai pills in treating premature ovarian failure determined by integrating UHPLC-Q-TOF-MS and network pharmacology analysis

Dang

Zhang²,

Su³

et al. 2022

BMC Complement Med Ther

View full text Add to dashboard Cite

Background Zishen Yutai (ZSYT) pill, a patent Chinese medicine, has been widely used in the treatment of infertility, abortion, and adjunctive treatment of in vitro fertilization (IVF) for decades. Recently, the results of clinical observations showed that premature ovarian failure (POF) patients exhibited improved expression of steroids and clinical symptoms associated with hormone disorders after treatment with Zishen Yutai pills. However, the pharmacological mechanism of action of these pills remains unclear. Methods The compounds of Zishen Yutai pills found in blood circulation were identified via ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) technique in the serum of POF mice after oral administration of Zishen Yutai pills. The potential targets of compounds were screened using Traditional Chinese Medicine Systems Pharmacology Database, Traditional Chinese Medicine Database@Taiwan, Drugbank Database, PubChem, HIT, Pharmapper, and Swiss Target Prediction. The target genes associated with POF were collected from Online Mendelian Inheritance in Man Database, PharmGkb, Genecards, Therapeutic Target Database, and Genetic Association Database. The overlapping genes between the potential targets of Zishen Yutai pills’ compounds and the target genes associated with POF were clarified via protein-protein interaction (PPI), pathway, and network analysis. Results Nineteen compounds in Zishen Yutai pills were detected in the serum of POF mice after oral administration. A total of 695 Zishen Yutai (ZSYT) pill-related targets were screened, and 344 POF-related targets were collected. From the results of Zishen Yutai (ZSYT) pill-POF PPI analysis, CYP19A1, AKR1C3, ESR1, AR, and SRD5A2 were identified as key targets via network analysis, indicating their core role in the treatment of POF with Zishen Yutai pills. Moreover, the pathway enrichment results suggested that Zishen Yutai pills treated POF primarily by regulating neuroactive ligand-receptor interaction, steroid hormone biosynthesis, and ovarian steroidogenesis. Conclusions Via virtual screening, we found that regulation of neuroactive ligand-receptor interaction, steroid hormone biosynthesis, and ovarian steroidogenesis was the potential therapeutic mechanism of Zishen Yutai pills in treating POF. Our study suggested that combining the analysis of Zishen Yutai pills’ compounds in blood in vivo in the POF model and network pharmacology prediction might offer a tool to characterize the mechanism of Zishen Yutai pills in the POF.

show abstract

The analysis estradiol levels against sexual desire in perimenopause women in Makassar, South Sulawesi, Indonesia

Sudirman

Sinrang

Marwang³

et al. 2020

Enfermería Clínica

View full text Add to dashboard Cite

The association between sexual dysfunction and metabolic syndrome among Turkish postmenopausal women

Cited by 9 publications

References 44 publications

The global prevalence of sexual dysfunction in obese and overweight women: a systematic review and meta-analysis

The global prevalence of sexual dysfunction in obese and overweight women: a systematic review and meta-analysis

Mechanisms of action of Zishen Yutai pills in treating premature ovarian failure determined by integrating UHPLC-Q-TOF-MS and network pharmacology analysis

The analysis estradiol levels against sexual desire in perimenopause women in Makassar, South Sulawesi, Indonesia

Contact Info

Product

Resources

About