The association between serum vitamin A and NAFLD among US adults varied in different BMI groups: a cross-sectional study

Zhang, Kaiwen; Nulali, Jiayida; Zhang, Cao-Xu; Chen, Yingchao; Cheng, Jing; Shi, Xiaye; Zhu, Chunfang; Lu, Yingli; Wang, Ningjian; Han, Bing

doi:10.1039/d2fo02204d

Cited by 7 publications

(3 citation statements)

References 40 publications

(60 reference statements)

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“…Further dose-response studies on antioxidant compounds may be warranted to elucidate the relationship. However, concerning the independent association between intake of vitamin A, vitamin C, vitamin E, and zinc with NAFLD, our results align with several prior studies [52][53][54][55] . Reactive oxygen species (ROS) and lipid peroxidation directly damage hepatocytes by affecting membranes, proteins, and DNA.…”

Section: Discussionsupporting

confidence: 92%

Association between the Composite Dietary Antioxidant Index and Nonalcoholic Fatty Liver Disease: Evidence from National Health and Nutrition Examination Survey 2005-2016

Fu,

Jiang,

et al. 2024

Preprint

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Importance: Oxidative stress is an important contributor to the progression of nonalcoholic fatty liver disease (NAFLD), however, the relationship between Composite Dietary Antioxidant Index (CDAI) and NAFLD in US adult population remains unclear. Objective: To access whether CDAI is associated with NAFLD in US adults. Design, setting, and participants: This population-based cross-sectional study used data on US adults from the National Health and Nutrition Examination Survey (NHANES) 2005-2016 cycles. Data were analyzed from January to February 2024. Exposures: CDAI obtained from the dietary intake questionnaire. Main outcomes and measures: The main outcome was NAFLD which defined by the US fatty liver score (USFLI) ≥ 30. Sampling weights were calculated according to NHANES guidelines. Results: Among 9746 adults included in this study (mean age, 48.3 years; 4662 [47.6%] males), 3324 (33.0%) were classified as having NAFLD using USFLI. In the fully adjusted of multivariable logistic regression, CDAI was negative associated with NAFLD (odds ratio [OR], 0.95; 95% CI, 0.93-0.98). Furthermore, the highest quartile CDAI were 34% less likely to have NAFLD than those with the lowest quartile (OR, 0.66; 95% CI, 0.52-0.85). In subgroup analyses, CDAI was associated with NAFLD among participants who were male (OR, 0.94; 95% CI, 0.92-0.97), without diabetes (OR, 0.95; 95% CI, 0.93-0.97), and without metabolic syndrome (OR, 0.93; 95% CI, 0.91-0.96). In addition, the negative correlation between CDAI and NAFLD was robust in sensitivity analyses that excluded potential hepatotoxic medication use (OR, 0.95; 95% CI, 0.93-0.98), or non-Hispanic Black participants (OR, 0.95; 95% CI, 0.93-0.98), defined NAFLD based on the hepatic steatosis index score (HSI) (OR, 0.97; 95% CI, 0.95-0.99), and used unweighted logistic analysis (OR, 0.96; 95% CI, 0.94-0.98). Conclusions and relevance: In this cross-sectional study based on six cycles (2005-2016) of the NHANES, CDAI was negative associated with NAFLD in US adult population. This association may provide a new approach to explore the factors affecting dietary interventions to reduce the incidence of NAFLD.

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Section: Discussionsupporting

confidence: 92%

Association between the Composite Dietary Antioxidant Index and Nonalcoholic Fatty Liver Disease: Evidence from National Health and Nutrition Examination Survey 2005-2016

Fu,

Jiang,

et al. 2024

Preprint

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“…Epidemiologic evidence has shown that inadequate vitamin A intake is a significant risk factor for MAFLD and that serum retinol levels are significantly lower in patients with advanced MAFLD [148][149][150]. However, there is also evidence that MAFLD progression may be associated with elevated serum vitamin A levels [151,152]. In addition, vitamin A metabolites, especially retinoic acid, influence the development of MAFLD mainly by affecting the regulatory network of hepatic glucose-lipid metabolism, as well as the interaction with insulin [153,154].…”

Section: Vitamin a Metabolism And Mafldmentioning

confidence: 99%

Examining the Pathogenesis of MAFLD and the Medicinal Properties of Natural Products from a Metabolic Perspective

Fu,

Wang,

Qin

2024

Metabolites

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Metabolic-associated fatty liver disease (MAFLD), characterized primarily by hepatic steatosis, has become the most prevalent liver disease worldwide, affecting approximately two-fifths of the global population. The pathogenesis of MAFLD is extremely complex, and to date, there are no approved therapeutic drugs for clinical use. Considerable evidence indicates that various metabolic disorders play a pivotal role in the progression of MAFLD, including lipids, carbohydrates, amino acids, and micronutrients. In recent years, the medicinal properties of natural products have attracted widespread attention, and numerous studies have reported their efficacy in ameliorating metabolic disorders and subsequently alleviating MAFLD. This review aims to summarize the metabolic-associated pathological mechanisms of MAFLD, as well as the natural products that regulate metabolic pathways to alleviate MAFLD.

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“…The information from the death certificates was used to derive the Clinical Modification System codes I00-I78 to determine the mortality rate resulting from all-cause mortality and cardiovascular diseases by the International Based on existing information relevant covariates such as age, sex, level of education (less than 9th grade, grades 9-11, high school graduate/GED or equivalent record of formal schooling, partial college or AA degree or above, college graduate or above), BMI, smoking history (never smoked, smoking history), drinking history (less or more than 12 cups/year), aspirin use, family poverty income ratio (PIR:<1.0; 1.0-3.0; >3.0), physical activity, diabetes status, total energy intake, and laboratory measures of blood lipids were included. The energy intake of adults was calculated using the USDA Food and Nutrient Database, available at https://www.ars.usda.gov/nea/bhnrc/ fsrg, which was designed to provide an effective and accurate method to collect intakes for large-scale national surveys (27). Detailed information on dietary vitamin B1 intake and other variables can be accessed at www.cdc.gov/nchs/nhanes/.…”

Section: Variablesmentioning

confidence: 99%

Association of vitamin B1 with cardiovascular diseases, all-cause and cardiovascular mortality in US adults

Wen,

Niu,

Zhao

et al. 2023

Front. Nutr.

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BackgroundThe correlation between dietary vitamin B1 intake and cardiovascular diseases, as well as the all-cause and cardiovascular-associated mortality, is not well known. A large-scale data pool was used to examine the aforementioned correlations of Vitamin B1.MethodsThis paper analyzed the dietary data from the survey conducted by National Health and Nutrition Examination (NHANES; 1999–2018). The correlation of vitamin B1 intake in each quartile with cardiovascular diseases such as hypertension, coronary heart disease, myocardial infarction and heart failure was analyzed using multivariate logistic regression models. The hazard ratios for dietary vitamin B1 intake in each quartile, along with all-cause and cardiovascular-associated mortality, were performed using multivariate cox regression analysis, setting the lowest quartile (Q1) as a reference. The restricted cubic spline (RCS) method was used to study the nonlinear relationship. Subgroup stratification and sensitivity analyses were used to further investigate the association between them.ResultsThe study enrolled 27,958 subjects (with a mean follow-up time of 9.11 years). After multivariate adjustment, dietary vitamin B1 intake was significantly associated with hypertension, heart failure and cardiovascular mortality, with the most significant association in quartile 4 (Q4) of vitamin B1 intake. The results of the restricted cubic spline showed that vitamin B1 intake was nonlinearly associated with hypertension, whereas it was linearly associated with heart failure and cardiovascular mortality. Meanwhile, a dose–response correlation was observed, indicating that increased vitamin B1 intake leads to reduced risk of both cardiovascular prevalence and mortality. The stratified analysis showed that the correlation between age ≥ 50 years, overweight, smoking history, drinking history and dyslipidemia were more significant in male patients. The associations remained similar in the sensitivity analyses.ConclusionThe large NHANES-based studies indicate a gradual trend toward decreasing the risk of hypertension and heart failure prevalence and cardiovascular mortality with increasing dietary vitamin B1 intake. This association is especially significant in elderly-aged men, overweight individuals, smokers, drinkers, and dyslipidemia patients.

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The association between serum vitamin A and NAFLD among US adults varied in different BMI groups: a cross-sectional study

Abstract: Background and Aims: The association between serum vitamin A (VA) and non-alcoholic fatty liver disease (NAFLD) has not been adequately studied. This study aimed to evaluate the association between them...

Cited by 7 publications

References 40 publications

Association between the Composite Dietary Antioxidant Index and Nonalcoholic Fatty Liver Disease: Evidence from National Health and Nutrition Examination Survey 2005-2016

Association between the Composite Dietary Antioxidant Index and Nonalcoholic Fatty Liver Disease: Evidence from National Health and Nutrition Examination Survey 2005-2016

Examining the Pathogenesis of MAFLD and the Medicinal Properties of Natural Products from a Metabolic Perspective

Association of vitamin B1 with cardiovascular diseases, all-cause and cardiovascular mortality in US adults

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