The association between serum uric acid and the incidence of prediabetes and type 2 diabetes mellitus: The Rotterdam Study

Schaft, Niels; Brahimaj, Adela; Wen, Kexin; Franco, Oscar H.; Dehghan, Abbas

doi:10.1371/journal.pone.0179482

Cited by 72 publications

(60 citation statements)

References 28 publications

(33 reference statements)

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“…Our data provide prospective confirmation of previous findings on the relationship between SUA levels and the risk of type 2 diabetes [12,13,[17][18][19][20][21][22][23][24][25][26]. The Rotterdam study showed that the risk of developing type 2 diabetes in the top quartile of uric acid was 1.68 times that in the lowest quartile [13].…”

Section: Discussionsupporting

confidence: 89%

“…Furthermore, Wu et al identified that SUA was positively associated with hyperinsulinemia and insulin resistance in prediabetic patients [30]. The Rotterdam Study agrees with the notion that SUA is more closely related to the early stages of the development of type 2 diabetes than late-phase mechanisms [23].…”

Section: Discussionmentioning

confidence: 67%

“…Data from animal and human experiments have indicated that UA mainly affects diabetes through inflammation, oxidative stress, and endothelial function damage [9,26,31]. It is also possible that elevated SUA may reflect prediabetes status, and SUA might be more closely associated with early-phase pathogenic mechanisms that contribute to the development of type 2 diabetes [20,23,30,32]. Potential biological mechanisms underlying the association between SUA and diabetes risk remain to be clarified by future studies.…”

Section: Discussionmentioning

confidence: 99%

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Serum Uric Acid Level as a Harbinger of Type 2 Diabetes: A Prospective Observation in Taiwan

Lai

Chou

et al. 2020

IJERPH

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Background: Current evidence suggests an association of uric acid with diabetes risk, but it is still unclear whether uric acid is merely a risk marker or an independent risk factor. We evaluate the impact of serum uric acid (SUA) levels on the future risk of developing type 2 diabetes, independent of other factors. Methods: A population-based cohort study was conducted among 4130 participants who were found to be free of type 2 diabetes at baseline recruitment in 2002. Baseline SUA measured in 2002 was longitudinally related to the incident type 2 diabetes that occurred during the follow-up period between 2002 and 2007. Hazard ratios (HRs) and 95% confidence intervals (CIs) derived from Cox proportional hazards models were used to quantify the association. Results: There was a graded increase in the incidence of type 2 diabetes among individuals with increasing levels of SUA. In the whole study cohort, compared to quartile 1, the multivariable-adjusted HRs (95% CIs) of type 2 diabetes in quartile 2, quartile 3, and quartile 4 were 1.69 (0.76–3.76), 1.86 (0.88–4.26), and 1.94 (1.05–4.05), respectively (P for trend = 0.004). This positive gradient for the risk of type 2 diabetes across quartiles of SUA was evident in both genders and across age groups. Conclusions: This study supports that high uric acid concentrations are associated with increased diabetes risk, independent of other known risk factors. These data expand on well-established associations between SUA level and metabolic syndrome, and extend the link to the future risk of type 2 diabetes.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

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Serum Uric Acid Level as a Harbinger of Type 2 Diabetes: A Prospective Observation in Taiwan

Lai

Chou

et al. 2020

IJERPH

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“…In addition, uric acid has been described as an antioxidant molecule [126] which will be discussed in the oxidative stress section. Elevated uric acid may become one of the most important molecular markers for early-phase mechanisms in the development of MetS and other metabolic diseases [127,128].…”

Section: Uric Acidmentioning

confidence: 99%

Detection of Early Disease Risk Factors Associated with Metabolic Syndrome: A New Era with the NMR Metabolomics Assessment

et al. 2020

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The metabolic syndrome is a multifactorial disease developed due to accumulation and chronification of several risk factors associated with disrupted metabolism. The early detection of the biomarkers by NMR spectroscopy could be helpful to prevent multifactorial diseases. The exposure of each risk factor can be detected by traditional molecular markers but the current biomarkers have not been enough precise to detect the primary stages of disease. Thus, there is a need to obtain novel molecular markers of pre-disease stages. A promising source of new molecular markers are metabolomics standing out the research of biomarkers in NMR approaches. An increasing number of nutritionists integrate metabolomics into their study design, making nutrimetabolomics one of the most promising avenues for improving personalized nutrition. This review highlight the major five risk factors associated with metabolic syndrome and related diseases including carbohydrate dysfunction, dyslipidemia, oxidative stress, inflammation, and gut microbiota dysbiosis. Together, it is proposed a profile of metabolites of each risk factor obtained from NMR approaches to target them using personalized nutrition, which will improve the quality of life for these patients.

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“…Almond intake, specifically, has been found to improve the lipoprotein lipid profile and postprandial glycemia (19,23). In addition, almond consumption may reduce serum uric acid concentration (24); hyperuricemia is a risk factor for both CVD and T2D (25,26). Almonds contain monounsaturated fatty acids (MUFA), polyunsaturated fatty acids (PUFA), protein, fiber, antioxidants, and magnesium (27), all of which may contribute to the favorable metabolic effects reported in observational studies and clinical trials (28,29), particularly when displacing foods high in refined CHO.…”

Section: Introductionmentioning

confidence: 99%

Effects of Consuming Almonds on Insulin Sensitivity and Other Cardiometabolic Health Markers in Adults With Prediabetes

Palacios

Maki

Xiao

et al. 2019

Journal of the American College of Nutrition

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Objective: This study was designed to assess the effects of replacing high-carbohydrate (CHO) foods with raw almonds on insulin sensitivity and cardiometabolic health markers in overweight or obese adults with prediabetes. Method: This randomized crossover study consisted of two 6-week dietary intervention periods, separated by a ! 4-week washout. Subjects incorporated 1.5 oz of raw almonds twice daily or isocaloric CHO-based foods into their diets, with instructions to maintain body weight. Dietary intakes as well as insulin sensitivity, CHO metabolism indices, lipoprotein lipids and particles, and inflammatory markers were assessed. Results: Thirty-three subjects (17 male, 16 female), mean age 48.3 ± 2.2 years and body mass index 30.5 ± 0.7 kg/m 2 , provided evaluable data. Compared to CHO, almonds resulted in significantly (p < 0.01) higher intakes of protein, fat (unsaturated fatty acids), fiber, and magnesium and significantly (p < 0.001) lower intakes of CHO and sugars. No differences were observed between diet conditions for changes from baseline in the insulin sensitivity index from a short intravenous glucose tolerance test or other indices of glucose homeostasis. No significant differences were observed in biomarkers of cardiovascular risk except that the CHO intervention led to a shift toward a higher concentration of cholesterol in small, dense low-density lipoprotein subfraction 3+4 (LDL3 þ 4) particles (p ¼ 0.024 vs almonds). Conclusions: Intake of 3.0 oz/d raw almonds, vs energy-matched CHO foods, improved the dietary nutrient profile, but did not significantly affect insulin sensitivity and most markers of cardiometabolic health in overweight and obese men and women with prediabetes.

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The association between serum uric acid and the incidence of prediabetes and type 2 diabetes mellitus: The Rotterdam Study

Cited by 72 publications

References 28 publications

Serum Uric Acid Level as a Harbinger of Type 2 Diabetes: A Prospective Observation in Taiwan

Serum Uric Acid Level as a Harbinger of Type 2 Diabetes: A Prospective Observation in Taiwan

Detection of Early Disease Risk Factors Associated with Metabolic Syndrome: A New Era with the NMR Metabolomics Assessment

Effects of Consuming Almonds on Insulin Sensitivity and Other Cardiometabolic Health Markers in Adults With Prediabetes

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