The Association between Serum Uric Acid and Residualβ-Cell Function in Type 2 Diabetes

Abstract

The aim of this study was to investigate the relationship of serum uric acid (sUA) with residual β-cell function in type 2 diabetes. Oral glucose tolerance tests (OGTT) were performed on 1021 type 2 diabetes patients. The ratio of area under curve of insulin to glucose during 0 to 30 min and 0 to 120 min of the OGTT was calculated as indices of insulin secretion function. The products of insulin secretion indices multiplied by Matsuda insulin sensitivity index were used as disposition indices. After correlation and multiple linear regression analysis, sUA was significantly associated with insulin secretion and disposition indices in male, female, and total groups adjusted for confounding factors (including metabolic indicators like sex, age, course of the disease, blood glucose, blood pressure, serum lipids, and so on). Superficially steeper time-dependent decline of insulin secretion function was found in patients with sUA above the median than those below it. In conclusion, our results suggest an independent positive association between sUA and residual β-cell function in type 2 diabetes. Patients with higher sUA have greater insulin secretion ability than those with lower sUA at the early stage of disease, but their residual β-cell function seems to decay more rapidly.

Associations between BMI, serum uric acid, serum glucose, and blood pressure with urinary tract stone opacity

“…Although several studies showed that BMI, hypertension, and uric acid serum were associated with composition of stone formation 2,24,26 our study showed no statistically significant associations.…”

Serum uric acid to creatinine ratio correlates with β‐cell function in type 2 diabetes

“…Although most clinical studies revealed a positive correlation between SUA level and islet β‐cell function in patients with T2DM, the correlation is still controversial. Mechanism researches show that SUA suppresses basal insulin release in isolated rat pancreatic islets and inhibits glucose‐stimulated insulin secretion .…”

“…The association between SUA and abnormal insulin secretion was also reported in subjects with normal or impaired glucose metabolism. A study conducted by Tang et al showed that patients with higher SUA have greater insulin secretion ability than those with lower SUA at the early stage of disease, but their residual β‐cell function seems to decay more rapidly . A positive relationship between SUA and total phase of insulin secretion among T2DM adults was also demonstrated by Robles by using hyperglycemia clamp technique .…”

Hyperuricaemia and development of type 2 diabetes mellitus in Asian population

“…Robles‐Cervantes et al reported that uric acid concentration had a positive relationship with insulin secretion, which may play an important role in the function of β‐cell in patients with T2DM. Tang et al reported that subjects with higher uric acid concentration have greater insulin secretion ability than those with lower uric acid at the early stage of T2DM, but their residual β‐cell function seems to decay more rapidly.…”