The association between serum irisin levels and cardiovascular disease in diabetic patients

Khorasani, Zahra Mazloum; Bagheri, Ramin Khameneh; Yaghoubi, Mohammad Ali; Chobkar, Saeed; Afzalaghaee, Monavar; Abbaszadegan, Mohammad Reza; Sahebkar, Amirhossein

doi:10.1016/j.dsx.2018.11.050

Cited by 30 publications

(21 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cardioprotective actions of irisin have also been previously reported. For example, serum irisin levels were reduced in diabetic patients and negatively correlated with cardiovascular events [ 68 ]. In type 2 diabetes model mice and hepatocytes, irisin inhibited hepatic gluconeogenesis and increased glycogen synthesis through the PI3K/Akt pathway [ 69 ].…”

Section: Discussionmentioning

confidence: 99%

[Retracted] Irisin Attenuates Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in the H9C2 Cellular Model of Septic Cardiomyopathy through Augmenting Fundc1‐Dependent Mitophagy

Jiang

Cai

Jin

et al. 2021

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

In the present study, we used lipopolysaccharide- (LPS-) stimulated H9C2 cardiomyocytes to investigate whether irisin treatment attenuates septic cardiomyopathy via Fundc1-related mitophagy. Fundc1 levels and mitophagy were significantly reduced in LPS-stimulated H9C2 cardiomyocytes but were significantly increased by irisin treatment. Irisin significantly increased ATP production and the activities of mitochondrial complexes I and III in the LPS-stimulated cardiomyocytes. Irisin also improved glucose metabolism and significantly reduced LPS-induced levels of reactive oxygen species by increasing the activities of antioxidant enzymes, glutathione peroxidase (GPX), and superoxide dismutase (SOD), as well as levels of reduced glutathione (GSH). TUNEL assays showed that irisin significantly reduced LPS-stimulated cardiomyocyte apoptosis by suppressing the activation of caspase-3 and caspase-9. However, the beneficial effects of irisin on oxidative stress, mitochondrial metabolism, and viability of LPS-stimulated H9C2 cardiomyocytes were abolished by silencing Fundc1. These results demonstrate that irisin abrogates mitochondrial dysfunction, oxidative stress, and apoptosis through Fundc1-related mitophagy in LPS-stimulated H9C2 cardiomyocytes. This suggests irisin is a potentially useful treatment for septic cardiomyopathy, though further investigations are necessary to confirm our findings.

show abstract

Section: Discussionmentioning

confidence: 99%

[Retracted] Irisin Attenuates Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in the H9C2 Cellular Model of Septic Cardiomyopathy through Augmenting Fundc1‐Dependent Mitophagy

Jiang

Cai

Jin

et al. 2021

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…The above results were in agreement with more recent results, by Khorasani et al, who found that serum Irisin level was lower in diabetic patients with cardiovascular complication compared with uncomplicated diabetic patients (10) .…”

Section: Discussionsupporting

confidence: 93%

Serum Levels of Novel Biochemical Marker (Irisin) in Relation to the Duration of Type 2 Diabetes & in Cases of Type 2 diabetes with Coronary Artery Disease in Iraqi Patients Aged (40- 60 year)

Al-Aridhi

Al-Lehibi

Al-Sharifi

et al. 2020

MLU

View full text Add to dashboard Cite

Background: Type 2 diabetes mellitus (T2DM) is a metabolic syndrome that affects a large proportion of the population, if not well controlled; this will lead to serious metabolic problems, including atherosclerosis, predominantly coronary artery disease (CAD).Irisin is a peptide hormone, secreted mainly by the heart and skeletal muscle. It has a role in converting white adipose tissue to brown adipose tissue. It is one of the novel biochemical markers that link diabetes with CAD.Objective : To explore the relationship between serum Irisin level and duration of diabetes, in cases of presence and absence of CAD, As well as the possibility of using it as a marker for the assessment of the severity of the disease. Method: One hundred sixty-one volunteers aged [(40-60 year), body mass index (20-25Kg/m 2 )], with normal blood pressure. They divided into six groups, that distributed as [(I a = control (negative catheterization without DM), I b = control (apparently healthy), II a = DM (with negative catheterization) II b = DM (diagnosed by history and clinical examination), III a = CAD (without DM, positive catheterization), III b = CAD + DM (positive catheterization)]. The diabetic groups with and without CAD had been divided depending on the duration of the diabetic onset into three periods (<5, 5-10, and > 10 years). The parameters that measured were FPG, HbA1c and fasting serum (Irisin, lipid profile). Results:The present findings showed the Means (± SD) value of Irisin levels was a significant decrease in (II a , II b , III a , III b ) groups as compared with control groups (I a , I b ). In addition, there is an inverse relationship between serum Irisin and the duration of DM in the total DM groups (II a +II b ) and the CAD + DM group (III b ). Moreover, higher statistical decrease in mean serum level of Irisin with duration of DM was found in CAD + DM group as compared with the total DM group. Also, there was a significant decrease in mean serum level of HDL-C for (II a , II b , III a , III b ) groups than in (I a , I b ) groups. Besides, there was a significant decrease in the mean of serum HDL level in CAD groups (III a , III b ) than in DM groups (II a , II b ). While the means of FPG level, HbA1c, serum cholesterol level, were significantly elevated in groups (II a , II b , III b ) as compared with (I a , I b ) groups. Also, there was a significant increase in the mean serum levels of triglyceride, VLDL-C and LDL-C for (II a , II b , III a , III b ) groups than in the control groups. Conclusion:Irisin was lower among patients with long-standing diabetes (with or without CAD) as compared to those with short duration of T2DM that can be included as a marker for assessment the severity of diabetes and prediction of CAD.

show abstract

“…In heart, irisin improving mitochondrial functions protects cardiomyoblasts from various injuries characterized by elevated ROS production, i.e., ischemic and reperfusion [143], high glucose-induced [144], and lipotoxic-induced injury [145]. Moreover, human different reports have shown that irisin levels were lower in the diabetic patients with cardiovascular complications [146] and in subjects with myocardial infarction or heart failure [147]. Finally, in a mouse model of cardiac ischemia, irisin treatment reduces infarct size, promotes neo angiogenesis, and enhances the reestablishment of cardiac function [148].…”

Section: Irisin: Biological Rolementioning

confidence: 99%

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Senesi

Luzi

Terruzzi

2020

IJMS

View full text Add to dashboard Cite

: It is now established that adipose tissue, skeletal muscle, and heart are endocrine organs and secrete in normal and in pathological conditions several molecules, called, respectively, adipokines, myokines, and cardiokines. These secretory proteins constitute a closed network that plays a crucial role in obesity and above all in cardiac diseases associated with obesity. In particular, the interaction between adipokines, myokines, and cardiokines is mainly involved in inflammatory and oxidative damage characterized obesity condition. Identifying new therapeutic agents or treatment having a positive action on the expression of these molecules could have a key positive effect on the management of obesity and its cardiac complications. Results from recent studies indicate that several nutritional interventions, including nutraceutical supplements, could represent new therapeutic agents on the adipo-myo-cardiokines network. This review focuses the biological action on the main adipokines, myokines and cardiokines involved in obesity and cardiovascular diseases and describe the principal nutraceutical approaches able to regulate leptin, adiponectin, apelin, irisin, natriuretic peptides, and follistatin-like 1 expression.

show abstract

The association between serum irisin levels and cardiovascular disease in diabetic patients

Cited by 30 publications

References 25 publications

[Retracted] Irisin Attenuates Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in the H9C2 Cellular Model of Septic Cardiomyopathy through Augmenting Fundc1‐Dependent Mitophagy

[Retracted] Irisin Attenuates Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in the H9C2 Cellular Model of Septic Cardiomyopathy through Augmenting Fundc1‐Dependent Mitophagy

Serum Levels of Novel Biochemical Marker (Irisin) in Relation to the Duration of Type 2 Diabetes & in Cases of Type 2 diabetes with Coronary Artery Disease in Iraqi Patients Aged (40- 60 year)

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Contact Info

Product

Resources

About