The association between serum ferritin levels and malignant intraductal papillary mucinous neoplasms

Zhuge, Xiaoling; Zhou, Hao; Chen, Liming; Chen, Hui; Chen, Xiao; Guo, Chuangen

doi:10.1186/s12885-021-08986-z

Cited by 8 publications

(6 citation statements)

References 41 publications

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“…A recent study indicates that mucin 5AC (MUC5AC) in a circulating extracellular vesicle can predict high-grade IPMNs with an AUC of 0.73 and predict invasive carcinoma with an AUC of 0.91 (32). Our previous study also reported that serum ferritin had acceptable performance (AUC = 0.67) (33). In the present study, our data further showed that the diagnostic power of PA alone was comparable to that of MPD or MN (AUC = 0.71) and the serum biomarkers of CA19-9 or serum ferritin or a circulating extracellular vesicle in identifying malignant IPMNs but lower than that of the circulating extracellular vesicle in identifying invasive carcinoma (32).…”

Section: Discussionmentioning

confidence: 75%

MRI-Based Pancreatic Atrophy Is Associated With Malignancy or Invasive Carcinoma in Intraductal Papillary Mucinous Neoplasm

Lin

Chen²,

Liu³

et al. 2022

Front. Oncol.

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BackgroundAbrupt change in the caliber of the main pancreatic duct (MPD) with distal pancreatic atrophy (PA) was considered as one of worrisome features in the International Association of Pancreatology guideline and American College of Gastroenterology guideline for the management of intraductal papillary mucinous neoplasms (IPMNs). However, this feature was not included in other guidelines. Moreover, the association between PA alone and malignancy in IPMNs has not been fully evaluated. In the present study, we investigated the role of image-based PA in identifying malignant IPMNs or invasive carcinoma.MethodsA total of 186 patients with IPMNs were included for analysis. The tumor size, location, MPD diameter, presence of a mural nodule (MN), and PA were evaluated using magnetic resonance imaging. Demographic information and serum carbohydrate antigen 19-9 and carcinoembryonic antigen (CEA) levels were also collected. IPMNs with high-grade dysplasia and associated invasive carcinoma were regarded as malignant IPMNs.ResultsPA was observed in 34 cases (18.3%). The occurrence of malignant IPMNs or invasive carcinoma in patients with PA were significantly higher than in those without PA (52.9% vs. 22.3%; 44.1% vs. 8.9%, all P < 0.01). Multivariate logistic regression analysis showed that PA was an independently associated factor for malignant IPMNs [odds ratio (OR) = 2.69, 95% confidence interval (CI): 1.07-6.78] or invasive carcinoma (OR = 7.78, 95%CI: 2.62-23.10) after modified with confounders. Subgroup analysis in MPD-involved IPMNs also indicated that PA was an independently associated factor for invasive carcinoma (OR = 9.72, 95%CI: 2.43-38.88). PA had a similar performance with MPD plus MN [the area under the curve (AUC) was both 0.71] in identifying malignancy. PA had a higher performance in identifying invasive carcinoma in MPD-involved IPMNs than MN (AUC = 0.71 vs. 0.65, P = 0.02).ConclusionOur data showed that imaging-based PA was associated with malignancy or invasive carcinoma regardless of abrupt change in the caliber of MPD in IPMNs. PA had an acceptable performance in identifying malignant IPMNs.

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Section: Discussionmentioning

confidence: 75%

MRI-Based Pancreatic Atrophy Is Associated With Malignancy or Invasive Carcinoma in Intraductal Papillary Mucinous Neoplasm

Lin

Chen²,

Liu³

et al. 2022

Front. Oncol.

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“…[24] However, when iron stores are in excess, the free iron content increases, which can enhance the oxidative stress response of the body, leading to an increase in blood pressure and causing the development of hypertensive disorders during pregnancy. [25] Vitamin D levels are altered in pregnant women during pregnancy, and elevated maternal D25-(OH)-D concentrations, which are higher than those in the fetus, can be transported to the fetus through the placenta to replenish vitamin D levels in the fetus. [26] Reduced maternal D25-(OH)-D levels have been found to be correlated with the severity of preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

Serum ferritin and 25-hydroxyvitamin D levels as predictors for premature birth in pregnant women with preeclampsia

Wang,

Xiao,

et al. 2023

Medicine

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This study aimed to investigate the expression levels of serum ferritin (SF) and 25-hydroxyvitamin D (25-[OH]-D) and analyze their predictive value for premature birth in pregnant women with preeclampsia. Between December 2018 and December 2021, 104 pregnant women with preeclampsia were selected as the observation group and 52 pregnant women with normal blood pressure as the control group. The observation group were divided into occurrence and nonoccurrence groups according to gestational age at birth. Relevant laboratory indicators were examined in both the occurrence and nonoccurrence groups, and the predictive value of SF and 25-(OH)-D levels for premature births in pregnant women with preeclampsia was analyzed. The incidence of premature delivery in the 104 pregnant women with preeclampsia was 20.19% (21/104). Pre-pregnancy body mass index (BMI), systolic blood pressure, diastolic blood pressure, 24 hours urinary protein, triglycerides, and SF levels of the pregnant women in the observation group were significantly higher, and the 25-(OH)-D levels were significantly lower, than those in the control group (P < .05). Furthermore, the pre-pregnancy BMI, systolic blood pressure, diastolic blood pressure, 24 hours urinary protein, and SF levels of pregnant women in the occurrence group were significantly higher, and the 25-(OH)-D levels were significantly lower, than those in the nonoccurrence group (P < .05). Logistic regression analysis showed that high pre-pregnancy BMI, systolic blood pressure, diastolic blood pressure, 24 hours urinary protein, and SF levels were risk factors for premature birth in pregnant women with preeclampsia (OR > 1, P < .05) and that high serum 25-(OH)-D was a protective factor (OR < 1, P < .05). In conclusion, SF and 25-(OH)-D levels are abnormally expressed in pregnant women with preeclampsia and are associated with premature birth in these women.

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“…Serum ferritin was found to have similar predictivity as CA19-9 in assessing IPMN. As discussed above, when CA19-9 is elevated in cases of IMPN, while not diagnostic, it is another concerning data point when considering malignant risk [ 67 ].…”

Section: Inflammationmentioning

confidence: 99%

The Role of Genetic, Metabolic, Inflammatory, and Immunologic Mediators in the Progression of Intraductal Papillary Mucinous Neoplasms to Pancreatic Adenocarcinoma

Shockley

Chen

et al. 2023

Cancers

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Intraductal papillary mucinous neoplasms (IPMN) have the potential to progress to pancreatic ductal adenocarcinoma (PDAC). As with any progression to malignancy, there are a variety of genetic and metabolic changes, as well as other disruptions to the cellular microenvironment including immune alterations and inflammation, that can contribute to tumorigenesis. Previous studies further characterized these alterations, revealing changes in lipid and glucose metabolism, and signaling pathways that mediate the progression of IPMN to PDAC. With the increased diagnosis of IPMNs and pancreatic cysts on imaging, the opportunity to attenuate risk with the removal of high-risk lesions is possible with the understanding of what factors accelerate malignant progression and how they can be clinically utilized to determine the level of dysplasia and stratify the risk of progression. Here, we reviewed the genetic, metabolic, inflammatory, and immunologic pathways regulating the progression of IPMN to PDAC.

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The association between serum ferritin levels and malignant intraductal papillary mucinous neoplasms

Cited by 8 publications

References 41 publications

MRI-Based Pancreatic Atrophy Is Associated With Malignancy or Invasive Carcinoma in Intraductal Papillary Mucinous Neoplasm

MRI-Based Pancreatic Atrophy Is Associated With Malignancy or Invasive Carcinoma in Intraductal Papillary Mucinous Neoplasm

Serum ferritin and 25-hydroxyvitamin D levels as predictors for premature birth in pregnant women with preeclampsia

The Role of Genetic, Metabolic, Inflammatory, and Immunologic Mediators in the Progression of Intraductal Papillary Mucinous Neoplasms to Pancreatic Adenocarcinoma

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