The association between serum creatine kinase, mood and psychosis in inpatients with schizophrenia, bipolar and schizoaffective disorders

Hollander, Sarah; Hochman, Eldar; Shoval, Gal; Taler, Michal; Trommer, Sharon; Hermesh, Haggai; Weizman, Abraham; Krivoy, Amir

doi:10.1016/j.psychres.2016.01.058

Cited by 9 publications

(2 citation statements)

References 39 publications

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“…Reagin, also called nontreponemal antigen, mainly comes from host tissue and cells destroyed by Treponema pallidum , and the intracellular K would be released at the same time. This finding is in accordance with the previous studies [17, 26]. …”

Section: Discussionsupporting

confidence: 94%

Association between schizophrenia and syphilis: a retrospective study in Xiamen, China

Zhang¹,

Xie²

2018

BMC Psychiatry

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BackgroundPrevious studies have shown that patients with mental illnesses such as schizophrenia have a higher risk for syphilis infection. However, the clinical characteristics of psychotic patients who are infected with syphilis remain unknown. The aim of this study was to investigate the prevalence of syphilis in psychotic patients in Xiamen and to compare the social function and serum biochemical markers between schizophrenia patients with and without syphilis.MethodsThere were a total of 1586 psychotic patients screened for syphilis from May 2016 to August 2017 in Xiamen Mental Health Center. We retrospectively studied 87 schizophrenia patients in this study. The NOSIE-30 score and serum biochemical markers were analyzed for all schizophrenia patients.ResultsThe seroprevalence of syphilis was 3.3% (52/1586) in our study. Schizophrenia patients infected with syphilis (SCZ-S) showed a higher irritability score compared with patients without syphilis (SCZ-C) (p < 0.05). Similarly, the serum CK, CK-MB, K and Cl values were significantly higher in the SCZ-S group than in the SCZ-C group (P < 0.05). In addition, the CK levels in SCZ-S drug-free patients were significantly higher than in drug-free patients in the SCZ-C group (P < 0.05).ConclusionThe seroprevalence of syphilis was 3.3% (52/1586) in our study, which revealed that psychotic patients were at high risk of being infected with Treponema pallidum. In addition, schizophrenia patients infected with syphilis can be more irritable and could have disrupted electrolyte and CK and CK-MB levels.

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Section: Discussionsupporting

confidence: 94%

Association between schizophrenia and syphilis: a retrospective study in Xiamen, China

Zhang¹,

Xie²

2018

BMC Psychiatry

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“…In addition, we observed significant correlations between changes in CK concentration and mood disturbance only for the SC group but not the placebo. Corroborating with our data, Hollander et al (2016) found an association between serum CK and psychological disorders, suggesting that CK may be used as a potential biomarker of affective state. Thus, further studies are necessary to understand the relationship between CK levels and psychological response.…”

Section: Discussionsupporting

confidence: 89%

Syzygium cumini Nectar Supplementation Reduced Biomarkers of Oxidative Stress, Muscle Damage, and Improved Psychological Response in Highly Trained Young Handball Players

et al. 2018

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The purpose of this study was to investigate the effects of Syzygium cumini (SC) nectar supplementation on performance, markers of oxidative stress, muscle damage, and psychological response in Handball players. Twenty-five young athletes (age = 18.6 ± 2.4 years) from an elite high school national level Brazilian Handball team were randomized into two study groups: SC/Jamelon nectar (SC, n = 12) and placebo (n = 13). The subjects ingested 10 mL/kg/day of Jamelon nectar or placebo 30 min before the training sessions and immediately after training cessation, for 28 days. Body mass index (BMI) and percentage of fat mass were assessed using bioelectrical impedance analysis. Biomarkers of oxidative stress were measured by lipid peroxidation, which was quantified by malondialdehyde (MDA). Total antioxidant capacity (TAC), creatine kinase (CK) activity, and lactate dehydrogenase (LDH) were determined. The 20 m shuttle run test, vertical jump, and running anaerobic sprint test were assessed to verify performance and the fatigue index was calculated. The Profile of Mood States (POMS) questionnaire was used for psychological evaluation. Both groups demonstrated improved vertical jump performance and a decreased fatigue index over time but without significant differences between them regarding performance. There was statistically significance only for SC in CK, LDH, and MDA, and TAC was greater in the SC compared to placebo. Furthermore, only the SC group demonstrated improved mood disturbance and confusion after the intervention. In conclusion, the present study suggests that SC nectar supplementation reduced biomarkers of oxidative stress and muscle damage, and improved psychological response in young handball players.

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Could schizoaffective disorder, schizophrenia and bipolar I disorder be distinguishable using cognitive profiles?

Chen

Lee

et al. 2018

Psychiatry Research

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The association between serum creatine kinase, mood and psychosis in inpatients with schizophrenia, bipolar and schizoaffective disorders

Cited by 9 publications

References 39 publications

Association between schizophrenia and syphilis: a retrospective study in Xiamen, China

Association between schizophrenia and syphilis: a retrospective study in Xiamen, China

Syzygium cumini Nectar Supplementation Reduced Biomarkers of Oxidative Stress, Muscle Damage, and Improved Psychological Response in Highly Trained Young Handball Players

Could schizoaffective disorder, schizophrenia and bipolar I disorder be distinguishable using cognitive profiles?

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