The association between serum albumin/prealbumin level and disease severity in non‐CF bronchiectasis

Li, Liyang; Li, Zhuozhe; Bi, Jianzhong; Li, Huayin; Wang, Sijiao; Shao, Chen; Song, Yuanlin

doi:10.1111/1440-1681.13331

Cited by 13 publications

(22 citation statements)

References 38 publications

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“…15 Serum albumin is another marker of inflammation and nutrition, but there are only a few studies showing that albumin level is associated with severity and prognosis in patients with bronchiectasis. 20,22 It has been reported that serum albumin levels are correlated with disease severity and modified Reiff scores in patients with bronchiectasis, and that it is a better indicator than prealbumin and BMI. 22 Serum albumin levels are also correlated with lung function decline and Bhalla score after controlling for age, BMI, and energy intake in patients with bronchiectasis.…”

Section: Discussionmentioning

confidence: 99%

“…20,22 It has been reported that serum albumin levels are correlated with disease severity and modified Reiff scores in patients with bronchiectasis, and that it is a better indicator than prealbumin and BMI. 22 Serum albumin levels are also correlated with lung function decline and Bhalla score after controlling for age, BMI, and energy intake in patients with bronchiectasis. 20 Our results are relatively consistent with the notion that serum albumin is associated with the clinical features of patients with bronchiectasis.…”

Section: Discussionmentioning

confidence: 99%

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Serum albumin is a predictor of respiratory hospitalization in patients with bronchiectasis

Jeong

Heo

et al. 2021

Chron Respir Dis

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We evaluated serum albumin as an index for predicting respiratory hospitalization in patients with bronchiectasis. We retrospectively reviewed the medical records of 177 patients with bronchiectasis, categorized them into low and normal albumin groups, and compared their clinical characteristics. The prediction of respiratory hospitalization by factors such as serum albumin level, bronchiectasis severity index (BSI), and FACED score (an acronym derived from five variables of forced expiratory volume in 1 s; FEV1, age, chronic colonization of Pseudomonas aeruginosa, extent of bronchiectasis, and dyspnea) was assessed. There were 15 and 162 patients categorized in the low and normal albumin groups, respectively. The low albumin group had lower body mass index and forced expiratory volume in 1 s, and higher age, frequency of previous respiratory hospitalization, percentage of Pseudomonas colonization, number of affected lobes, BSI and FACED scores, and C-reactive protein (CRP) level, than the normal albumin group. The areas under the receiver operating characteristic curve of serum albumin level and BSI and FACED scores for predicting respiratory hospitalization were 0.732 (95% confidence interval (CI), 0.647–0.816), 0.873 (95% CI, 0.817–0.928), and 0.708 (95% CI, 0.618–0.799), respectively. Albumin level, CRP, modified Medical Research Council score, and chronic Pseudomonas aeruginosa (and other organisms) colonization were independent risk factors for respiratory hospitalization. Low serum albumin level was associated with worse clinical condition, higher severity scores, and respiratory hospitalization in patients with bronchiectasis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serum albumin is a predictor of respiratory hospitalization in patients with bronchiectasis

Jeong

Heo

et al. 2021

Chron Respir Dis

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“…Our findings showed that the BMI of patients with asthma-CRS bronchiectasis decreased as the degree of bronchiectasis deteriorated. Similarly, previous studies also indicated that bronchiectasis can lead to malnutrition with lower BMI in patients with asthma [ 35 ]. Bronchiectasis patients with a lower BMI were prone to develop more acute exacerbations, worse pulmonary function and higher risk of death because of amplified systemic inflammation and chronic bacterial colonization [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 61%

“…Similarly, previous studies also indicated that bronchiectasis can lead to malnutrition with lower BMI in patients with asthma [ 35 ]. Bronchiectasis patients with a lower BMI were prone to develop more acute exacerbations, worse pulmonary function and higher risk of death because of amplified systemic inflammation and chronic bacterial colonization [ 35 , 36 ]. Taken together, our results suggest that the severity of bronchiectasis in asthma-CRS patients predicts a poor nutritional status and quality of life and should be surveilled and treated.…”

Section: Discussionmentioning

confidence: 61%

Prevalence and clinical implications of bronchiectasis in patients with overlapping asthma and chronic rhinosinusitis: a single-center prospective study

et al. 2021

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Background As a typical “united airway” disease, asthma-chronic rhinosinusitis (CRS) overlap has recently drawn more attention. Bronchiectasis is a heterogeneous disease related to a variety of diseases. Whether bronchiectasis exists and correlates with asthma-CRS patients has not been fully elucidated. The purpose of the study was to explore the presence and characteristics of bronchiectasis in patients with overlapping asthma and CRS. Methods This report describes a prospective study with consecutive asthma-CRS patients. The diagnosis and severity of bronchiectasis were obtained by thorax high-resolution computed tomography (HRCT), the Smith radiology scale and the Bhalla scoring system. CRS severity was evaluated by paranasal sinus CT and the Lund-Mackay (LM) scoring system. The correlations between bronchiectasis and clinical data, fraction of exhaled nitric oxide, peripheral blood eosinophil counts and lung function were analyzed. Results Seventy-two (40.91%) of 176 asthma-CRS patients were diagnosed with bronchiectasis. Asthma-CRS patients with overlapping bronchiectasis had a higher incidence rate of nasal polyps (NPs) (P = 0.004), higher LM scores (P = 0.044), higher proportion of ≥ 1 severe exacerbation of asthma in the last 12 months (P = 0.003), lower postbronchodilator forced expiratory volume in one second (FEV1) % predicted (P = 0.006), and elevated peripheral blood eosinophil counts (P = 0.022). Smith and Bhalla scores were shown to correlate positively with NPs and negatively with FEV1% predicted and body mass index. Cutoff values of FEV1% predicted ≤ 71.40%, peripheral blood eosinophil counts > 0.60 × 109/L, presence of NPs, and ≥ 1 severe exacerbation of asthma in the last 12 months were shown to differentiate bronchiectasis in asthma-CRS patients. Conclusions Bronchiectasis commonly overlaps in asthma-CRS patients. The coexistence of bronchiectasis predicts a more severe disease subset in terms of asthma and CRS. We suggest that asthma-CRS patients with NPs, severe airflow obstruction, eosinophilic inflammation, and poor asthma control should receive HRCT for the early diagnosis of bronchiectasis.

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“…Among patients in the bronchiectasis research registry, underweight patients had lower lung function measured by FEV 1 % predicted [ 35 ]. In a separate recent study, low BMI was also correlated with increased disease severity (Bronchiectasis Severity Index), QOL (QoL-B), and symptoms (Leicester Cough Questionnaire) [ 36 ]. A large cohort study of more than 5.6 million persons in the South Korean national health care system who had regular pulmonary exams found that decreasing BMI was inversely related to the risk of NTM PD [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

The 6-minute walk test predicts mortality in a pulmonary nontuberculous mycobacteria-predominant bronchiectasis cohort

Blakney

Ricotta

Follmann³

et al. 2022

BMC Infect Dis

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Background Bronchiectasis is a chronic lung condition frequently associated with nontuberculous mycobacteria pulmonary (NTM) disease. Persons with these conditions are at increased risk of mortality. Patient reported outcome (PRO) instruments and the 6-minute walk test (6MWT) have been shown to predict mortality for several lung conditions, but these measures have not been fully evaluated for bronchiectasis and NTM. Methods We conducted a retrospective cohort study among adult patients enrolled in a natural history study of bronchiectasis at the National Heart, Lung, and Blood Institute. Electronic medical records were queried for demographic, clinical, microbiologic, radiographic, and PRO instrument data: St. George’s Respiratory Questionnaire (SGRQ), Medical Research Council Dyspnea Scale, and the Pulmonary Symptom Severity Score (PSSS). The study baseline date was defined as the patient’s first visit after January 1st, 2015 with a SGRQ or 6MWT completed. Follow-up was defined as the interval between the study baseline visit and date of death or December 31st, 2019. Sex-stratified Cox proportional-hazards regression was conducted to identify predictors of mortality. Separate models were run for each PRO and 6MWT measure, controlling for age, body mass index (BMI), fibrocavitary disease status, and M. abscessus infection. Results In multivariable Cox proportional-hazards regression models, the PSSS-severity (aHR 1.29, 95% CI 1.04–1.59), the 6MWT total distance walked (aHR 0.938, 95% CI 0.896–0.981) and distance saturation product (aHR 0.930, 95% CI 0.887–0.974) independently predicted mortality. In addition, BMI was significantly predictive of mortality in all models. Conclusions The 6MWT and a PRO instrument capturing symptom severity are independently predictive of mortality in our cohort of bronchiectasis patients.

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The association between serum albumin/prealbumin level and disease severity in non‐CF bronchiectasis

Cited by 13 publications

References 38 publications

Serum albumin is a predictor of respiratory hospitalization in patients with bronchiectasis

Serum albumin is a predictor of respiratory hospitalization in patients with bronchiectasis

Prevalence and clinical implications of bronchiectasis in patients with overlapping asthma and chronic rhinosinusitis: a single-center prospective study

The 6-minute walk test predicts mortality in a pulmonary nontuberculous mycobacteria-predominant bronchiectasis cohort

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