The Association between Serum 25-Hydroxy Vitamin D Level and Urine Cathelicidin in Children with a Urinary Tract Infection

Hacıhamdioğlu, Duygu Övünç; Altun, Demet; Hacıhamdioğlu, Bülent; Çekmez, Ferhat; Aydemir, Gökhan; Kul, Mustafa; Müftüoğlu, Tuba; Süleymanoğlu, Selami; Karademır, Ferhan

doi:10.4274/jcrpe.2563

Cited by 41 publications

(48 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They concluded that vitamin D can prevent the occurrence of UTI using increasing mechanism of urine cathelicidin level. 26) It was reported that cathelicidin stimulated the production of chemokines and cytokines by different cells and provided the integrity of the urinary system. 27 28 29 30 31 32) It is believed that when there is a vitamin D deficiency, macrophages infected with bacterial agents (such as gram-negative bacteria) are not able to produce adequate antibacterial peptides.…”

Section: Discussionmentioning

confidence: 99%

Association between vitamin D and urinary tract infection in children

et al. 2018

View full text Add to dashboard Cite

PurposeThe present study aimed to determine the relationship between serum 25-hydroxyvitamin D (25(OH)D) level and Urinary tract infections (UTIs) in children.MethodsIn this case-control study, 70 children with UTI (case group) were compared with 70 healthy children (control group) in terms of serum 25(OH)D levels. The children were between 1 month and 12 years of age. Serum 25(OH)D levels were measured using enzyme-linked immunosorbent assay (ELISA). The results were analyzed and compared between both groups.ResultsAmong 70 children with UTI (case group), 5 children (7.2%) were male and 65 (92.8%) were female. Among the healthy children (control group), 9 (12.8%) and 61 children (87.2%) were male and female, respectively (P=0.39). The mean±standard deviation of age in the case and control groups were 53.2±35.6 and 36.1±60.2 months, respectively (P=0.24). The mean level of serum 25(OH)D in the case group was significantly higher than that of the control group (20.4±8.6 ng/mL vs. 16.9±7.4 ng/mL, P=0.01).ConclusionThis study showed that there was a relationship between serum 25(OH)D levels and UTI in children. It seems that 25(OH)D plays a role in the pathogenesis of UTI.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between vitamin D and urinary tract infection in children

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Nielsen et al, reported that, the urinary LL-37 levels were significantly higher during infection than post infection, yet the post infection LL-37 levels were significantly lower in patients with UTI than those of controls [ 32 ]. In another setting, Ovunç Hacıhamdioglu D. et al, showed no significant differences in the levels of urinary LL-37 between the children with UTI and the control groups [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

The impact of cathelicidin, the human antimicrobial peptide LL-37 in urinary tract infections

et al. 2018

View full text Add to dashboard Cite

BackgroundThe defense mechanisms of the urinary tract are attributed mainly to the innate immune system and the urinary tract urothelium which represent the first line of defense against invading pathogens and maintaining sterility of the urinary tract. There are only a few publications regarding cathelicidin (LL-37) and a urinary tract infection (UTI). This study was done to investigate the plasma and urine levels of human LL-37 in patients with UTI.MethodsA case-control study was conducted at Omdurman Hospital, Sudan during the period from August 2014 to May 2017. The cases were patients with confirmed UTI and the controls were healthy volunteers without UTI. Sociodemographic and clinical data were obtained from each participant using questionnaires. Urine cultures and antimicrobial susceptibility were tested. Plasma and urine levels of LL-37 were determined using an enzyme-linked immunosorbent assay (ELISA) kit. SPSS (version 16.0) was used for analyses.ResultsCases and controls (87 in each arm) were matched according to their basic characteristics. Compared with controls, the median (inter-quartile) LL-37 level in plasma [2.100 (1.700–2.700) vs. 1.800 (1.000–2.200) ng/ml, P = 0.002] and in urine [0.900 (0.300–1.600) vs. 0.000 (0.000–1.000) ng/mg creatinine, P < 0.001] was significantly higher in cases. There was no significant difference in the median plasma [2.1 (1.7–2.9) vs. 2.000 (1.700–2.400) ng/ml, P = 0.561] and urine [0.850 (0.275–2.025) vs. 0.900 (0.250–1.350) ng/mg creatinine, P = 0.124]. The uropathogenic Escherichia coli (UPEC) was the predominant isolate, n = 38 (43.7%). LL-37 levels between the E. coli isolates and the other isolated organisms. There was no significant correlation between plasma and urine LL-37 levels (r = 0.221), even when the data of the cases were analyzed separately.ConclusionLL-37 is notably increased among patients with UTI compared with normal control subjects. Severity of UTI increases the levels of LL-37. The increased level was not only in the patient’s urine, but has also been observed in the patient’s plasma. Detection of increased levels of LL-37 could help to differentiate subjects with suspected UTI. Accordingly, LL-37 could act as a good marker for diagnosing UTIs.

show abstract

“…Therefore, Vitamin D has the potential to protect the urinary tract against infection by modulating the production of AMPs. Both pediatric and premenopausal studies revealed that Vitamin D deficiency correlates with a higher frequency and severity of UTI (Nseir et al, 2013 ; Hacihamdioglu et al, 2016 ), suggesting a promising role of vitamin D as a potential complement in the prevention of UTI (Hertting et al, 2010 ; Luthje and Brauner, 2016 ).…”

Section: Alternative Antimicrobial Remediesmentioning

confidence: 99%

UroPathogenic Escherichia coli (UPEC) Infections: Virulence Factors, Bladder Responses, Antibiotic, and Non-antibiotic Antimicrobial Strategies

2017

View full text Add to dashboard Cite

Urinary tract infections (UTIs) are one of the most common pathological conditions in both community and hospital settings. It has been estimated that about 150 million people worldwide develop UTI each year, with high social costs in terms of hospitalizations and medical expenses. Among the common uropathogens associated to UTIs development, UroPathogenic Escherichia coli (UPEC) is the primary cause. UPEC strains possess a plethora of both structural (as fimbriae, pili, curli, flagella) and secreted (toxins, iron-acquisition systems) virulence factors that contribute to their capacity to cause disease, although the ability to adhere to host epithelial cells in the urinary tract represents the most important determinant of pathogenicity. On the opposite side, the bladder epithelium shows a multifaceted array of host defenses including the urine flow and the secretion of antimicrobial substances, which represent useful tools to counteract bacterial infections. The fascinating and intricate dynamics between these players determine a complex interaction system that needs to be revealed. This review will focus on the most relevant components of UPEC arsenal of pathogenicity together with the major host responses to infection, the current approved treatment and the emergence of resistant UPEC strains, the vaccine strategies, the natural antimicrobial compounds along with innovative anti-adhesive and prophylactic approaches to prevent UTIs.

show abstract

The Association between Serum 25-Hydroxy Vitamin D Level and Urine Cathelicidin in Children with a Urinary Tract Infection

Cited by 41 publications

References 21 publications

Association between vitamin D and urinary tract infection in children

Association between vitamin D and urinary tract infection in children

The impact of cathelicidin, the human antimicrobial peptide LL-37 in urinary tract infections

UroPathogenic Escherichia coli (UPEC) Infections: Virulence Factors, Bladder Responses, Antibiotic, and Non-antibiotic Antimicrobial Strategies

Contact Info

Product

Resources

About