2008
DOI: 10.1080/15287390802240850
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The Association Between Serotonin Transporter Gene Promoter Polymorphism (5-HTTLPR), Self-Reported Symptoms, and Dental Mercury Exposure

Abstract: The associations between a polymorphism of the serotonin transporter gene (5-HTTLPR), dental mercury exposure, and self-reported symptoms were evaluated among 157 male dentists and 84 female dental assistants. Self-reported symptoms and detailed work histories were obtained by computerized questionnaire. Spot urine samples were collected and analyzed for mercury concentrations to evaluate recent exposures, whereas a chronic mercury exposure index was created from the work histories. 5-HTTLPR polymorphism statu… Show more

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Cited by 22 publications
(20 citation statements)
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References 44 publications
(61 reference statements)
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“…Here, children who were genotyped with common variants of genes that have been previously shown to elicit no or only additive effects with Hg on neurobehavioral functions in adults, e.g., BDNF, CPOX, COMT, 5-HTTLPR (Echeverria et al, 2005, 2006, 2010; Heyer et al, 2004, 2008, 2009), displayed numerous significant interactive effects on comparable tests of neurobehavioral function at similar levels of Hg exposure. Since adverse neurobehavioral effects were found only among children having gene modifications, genexHg interactions are assumed to underlie these effects.…”
Section: Discussionmentioning
confidence: 99%
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“…Here, children who were genotyped with common variants of genes that have been previously shown to elicit no or only additive effects with Hg on neurobehavioral functions in adults, e.g., BDNF, CPOX, COMT, 5-HTTLPR (Echeverria et al, 2005, 2006, 2010; Heyer et al, 2004, 2008, 2009), displayed numerous significant interactive effects on comparable tests of neurobehavioral function at similar levels of Hg exposure. Since adverse neurobehavioral effects were found only among children having gene modifications, genexHg interactions are assumed to underlie these effects.…”
Section: Discussionmentioning
confidence: 99%
“…Such studies are relevant, however, in light of recent findings (Basu, et al, 2013; Echeverria et al, 2005, 2006, 2010; Goodrich et al, 2011; Gundacker et al, 2007, 2009; Heyer et al, 2004, 2008, 2009; Schläwicke Engstrom et al, 2008; Wang et al, 2012) identifying common variants of numerous genes that modify the effects of Hg on neurologic functions and/or Hg handling in human subjects. Identification of genetic polymorphisms that affect Hg neurotoxicity is of particular importance with regard to assessment of Hg risks in children, who may be uniquely susceptible, compared with adults, because of their smaller body mass and more rapidly developing, hence more fragile, nervous and metabolic systems (Landrigan and Goldman, 2011).…”
Section: Introductionmentioning
confidence: 99%
“…As in our previous reports regarding studies with this dental professional cohort (Heyer et al, 2004, 2008; Woods et al, 2005; Echeverria et al, 2005, 2006), results for the (male) dentists and (female) dental assistants are analyzed and reported separately. This decision is based on the differences in the measures of Hg 0 exposure, age structures, education and training, and symptom reporting profiles for these two groups (Table 1).…”
Section: Methodsmentioning
confidence: 99%
“…In evaluating issues surrounding susceptibility to the neurological effects of Hg 0 at such low levels of exposure, it becomes necessary to take into account other biological causes for these effects, in particular, polymorphisms among genes that are known to influence the same neurobehavioral functions that are adversely impacted by Hg 0 exposure. In this regard, studies in an established cohort of occupationally exposed dental professionals have previously evaluated polymorphisms of genes influencing the production of coproporphyrinogen oxidase (CPOX)(Woods et al, 2005; Echeverria et al, 2006; Heyer et al, 2006), brain-derived neurotropic factor (BDNF) (Heyer et al, 2004; Echeverria et al, 2005), and the serotonin transporter gene promoter region (5-HTTLPR) (Heyer et al, 2008). CPOX was the first polymorphism studied, as it, along with Hg 0 , impacts the biosynthesis of heme, a likely mitigating factor in neurological signaling and neuronal functions (Chernova et al, 2007).…”
mentioning
confidence: 99%
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