The Association Between Serological Markers of Celiac Disease and Idiopathic Recurrent Pregnancy Loss

Sarıkaya, Esma; Tokmak, Aytekin; Aksoy, Rıfat Taner; Pekcan, Meryem Kuru; Alışık, Murat; Alkan, Afra

doi:10.1080/15513815.2017.1346018

Cited by 9 publications

(6 citation statements)

References 17 publications

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“…European populations were studied in 8 works [9,10,14,17,18,19,23,32], and 8 additional studies consider populations with a predominant Caucasian component [12,13,21,22,25,30,31,33]. The remaining 7 studies include populations from countries with an important representation of different ethnic groups [11,20,24,26,27,28,29].…”

Section: Resultsmentioning

confidence: 99%

“…The definition of CD differs among authors, sometimes including only seroprevalence. Specifically, 10 works were based only on serological results [10,11,18,21,23,25,28,30,31,33] and 13 included a duodenal biopsy after serological screening [9,12,13,14,17,19,20,22,24,26,27,29,32]. It must be also considered that the selected articles were published between 1976 and 2019, and the serological tests used for CD screening vary according to the technological and scientific advances.…”

Section: Resultsmentioning

confidence: 99%

“…Eighteen studies [10,11,13,14,20,21,22,23,24,25,26,27,28,29,30,31,32,33] reported the seroprevalence of CD assessing anti-TG2 antibodies in women presenting overall infertility, comprising a total of 5319 women. Figure 2a shows the forest plot with the results of this meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

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Systematic Review and Meta-Analysis of Prevalence of Coeliac Disease in Women with Infertility

et al. 2019

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We aimed to estimate the seroprevalence and the prevalence of coeliac disease (CD) in women with reproductive problems. A systematic review of English published articles until June 2019 was performed in PubMed and Scopus using the terms: (infertility and (coeliac disease OR gluten) OR (miscarriage and (coeliac disease OR gluten) OR (abortion and (coeliac disease OR gluten). All articles showing numerical data of anti-transglutaminase type 2 or anti-endomisium antibodies, or intestinal biopsy information were included. The study group comprised women with overall infertility, unexplained infertility, or recurrent spontaneous abortions. Two authors independently performed data extraction using a predefined data sheet. The initial search yielded 310 articles, and 23 were selected for data extraction. After meta-analysis, the pooled seroprevalence was very similar for overall and unexplained infertility, with a pooled proportion of around 1.3%–1.6%. This implies three times higher odds of having CD in infertility when compared to controls. The pooled prevalence could not be accurately calculated due to the small sample sizes. Further studies with increased sample sizes are necessary before giving specific recommendations for CD screening in women with reproductive problems, but current data seem to support a higher risk of CD in these women.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Systematic Review and Meta-Analysis of Prevalence of Coeliac Disease in Women with Infertility

et al. 2019

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“…[1,2] In that association, antitransglutaminase antibodies were accused that were causing impaired apoptosis of syncytiotrophoblasts and disturbed endometrial receptivity which was in turn resulting in implantation and placentation disorder. [3] However, recently, Sarikaya et al did not determine any association between antitransglutaminase antibodies and unexplained recurrent pregnancy losses. [4] In our case, while investigating for mild elevations in liver function tests, the patient was diagnosed with celiac disease and responded well to the gluten free diet and gave a healthy birth.…”

Section: Discussionmentioning

confidence: 98%

An Unusual Presentation of Celiac Disease: Recurrent Spontaneous Abortus

Yozgat¹

2021

Lokman Hekim Health Sci

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“…According to a relevant study, in celiac women, anti-transglutaminase antibody is capable of recognizing antigenic determinants on syncytiotrophoblast, inhibiting the transglutaminase action in the placenta and disturbing the placental function [65]. However, there are studies that do not support the correlation between celiac disease and presence of anti-transglutaminase and anti-endomysial antibodies with adverse pregnancy outcomes, in which screening for these autoantibodies was not recommended in women with RPL history [66][67][68]. Further investigations are required in order to better understand the correlation between celiac disease and reproductive failures.…”

Section: Humoral Immunitymentioning

confidence: 99%

Recent Advances in Immunotherapeutic Approaches for Recurrent Reproductive Failure

Abdolmohammadi-Vahid¹,

Aghebati‐Maleki²,

Ahmadian-Heris³

et al. 2023

IVF Technologies and Infertility - Current Practices and New Perspectives

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Human reproduction is an insufficient process, disturbed by various factors, such as immunologic aberrations of mother. Immunologic abnormalities, including cellular and humoral immunity imbalance, cause dysregulated immune responses against embryo, fetus, and associated components and lack of maternal immunotolerance, which compromise the maintenance of pregnancy. Therefore, evaluation of immunologic parameters, including cellular and humoral immunity assessment (T and B lymphocyte, T helper subtypes, NK cells, cytokines, and autoantibodies), especially in women with a history of pregnancy loss or implantation failure, would help clinicians to manage the disorder and prevent next unfavorable pregnancy outcomes. Moreover, several immunomodulatory approaches have been introduced to modulate the abnormal immunologic responses in patients who experience reproduction failure, especially those diagnosed with immunologic basis. Anticoagulants, corticosteroids, intravenous immunoglobulin, immunosuppressive medications used in inhibition of graft rejection, such as calcineurin inhibitors, recombinant cytokines, and cell therapy approaches, are among these modalities. Here, we discuss the proposed mechanisms of immunologic abnormalities involved in the etiopathogenesis of reproduction disorders, besides the suggested immunologic tests and immunotherapeutic approaches which may be helpful in management of these disorders.

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The Association Between Serological Markers of Celiac Disease and Idiopathic Recurrent Pregnancy Loss

Abstract: There is no association between CD markers and unexplained RPL. For the present, we do not recommend screening for ATA IgA and ATA IgG in patients with a history of RPL.

Cited by 9 publications

References 17 publications

Systematic Review and Meta-Analysis of Prevalence of Coeliac Disease in Women with Infertility

Systematic Review and Meta-Analysis of Prevalence of Coeliac Disease in Women with Infertility

An Unusual Presentation of Celiac Disease: Recurrent Spontaneous Abortus

Recent Advances in Immunotherapeutic Approaches for Recurrent Reproductive Failure

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