The association between sarcopenia and osteoporotic vertebral compression refractures

Wang, W.-F.; Lin, Chaowei; Xie, Cheng-Long; Liu, H.-T; Zhu, Mingyang; Huang, Kate; Teng, Hui

doi:10.1007/s00198-019-05144-x

Cited by 43 publications

(44 citation statements)

References 29 publications

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“…Studies have reported that the reason for high fragility fracture rate in underweight individuals is related to muscle loss. According to one study, sarcopenia is associated with older age, low BMI, and low bone density [23].…”

Section: Discussionmentioning

confidence: 99%

Association between body mass index and fragility fracture in postmenopausal women: a cross-sectional study using Korean National Health and Nutrition Examination Survey 2008–2009 (KNHANES IV)

et al. 2021

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Background The present study examined the relationship between body mass index (BMI) and the risk for fragility fractures in postmenopausal Korean women. Methods Among subjects who participated in the 4th Korea National Health and Nutrition Examination Survey (2008–2009), 2114 women ≥ 40 years of age were included. BMI was based on standards set by the Korean Society for the Study of Obesity, as follows: < 18.5 kg/m2, underweight; 18.5 ≤ to < 25 kg/m2, normal weight; and ≥ 25 kg/m2, obese. Subjects were also divided into three groups according to the location of fragility fracture: spine, hip, or wrist. Results The mean (± SD) rate of fragility fracture was significantly different among the three groups: 5.9 ± 2.9% (underweight), 1.1 ± 0.3% (normal weight), and 3.0 ± 0.7% (obese) (p = 0.001). After correcting for age, family history, and treatment history of osteoporosis and rheumatoid arthritis, smoking and drinking status, and level of exercise, multivariable regression analysis revealed that the odds ratio for fragility fracture in the underweight group was 5.48 [95% confidence interval (CI) 1.80–16.73] and 3.33 (95% CI 1.61–6.87) in the obese group. After subdividing fragility fractures into vertebral and non-vertebral, the odds ratio for vertebral fracture in the underweight group was 5.49 (95% CI 1.31–23.09) times higher than that in the normal weight group; in the obese group, the non-vertebral fracture odds ratio was 3.87 (95% CI 1.45–10.33) times higher. Analysis of non-vertebral fractures in the obese group revealed an odds ratio for fracture 22.05 (95% CI 1.33–365.31) times higher for hip fracture and 3.85 (95% CI 1.35–10.93) times higher for wrist fracture. Conclusions Obesity and underweight increased the risk for fragility fractures in postmenopausal Korean women.

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Section: Discussionmentioning

confidence: 99%

Association between body mass index and fragility fracture in postmenopausal women: a cross-sectional study using Korean National Health and Nutrition Examination Survey 2008–2009 (KNHANES IV)

et al. 2021

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“…Studies in China also found that sarcopenia is an independent risk predictor for osteoporotic vertebral compression fractures [28]. In another study, osteoporosis patients were at risk of muscle strength decline [29].…”

Section: Discussionmentioning

confidence: 94%

A Cross-sectional Study: Association Between sarcopenia and Osteoporosis in Type 2 Diabetes Mellitus Patients With a High Glycated Hemoglobin Level

Lingna

et al. 2020

Preprint

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Abstract Background: Sarcopenia and osteoporosisare commonly observed in individuals with type 2 diabetes mellitus (T2DM).Thus, this study investigated the association between sarcopenia and osteoporosis in T2DM patients with a highglycated hemoglobin (HbA1c)level.Methods: This study recruited 98 Chinese patients with T2DM who were aged ≥ 50 years, and their body compositions were evaluated using dual-energy X-ray absorptiometry. Moreover, the fFasting blood glucose, HbA1c, B collagen-specific sequences (B-CTX), osteocalcin(OC), propeptide of type 1 procollagen(P1NP), 25-hydroxy vitamin Dlevels were evaluated.Sarcopenia was defined as skeletal muscle mass index (SMI) <7.0 kg/m2 for men and < 5.4 kg/m2 for women.Results: There were 42 men and 56 women, with an average age of 65.86 ± 8.32 years and HbA1c level of 8.59% ± 1.87%. The prevalence rates ofsarcopenia, osteopenia, and osteoporosis were48.0%, 37.8%, and 33.6%, respectively.Moreover, the prevalence of osteoporosis was significantly higher in women than in men (50% vs. 11.9%, P = 0.000).The prevalence of sarcopenia was significantly higher in patients with HbA1c levels> 9.0% than in those with HbA1c levels < 9.0% (62.2% vs. 39.3%, P = 0.037). However, the prevalence of osteopenia and osteoporosis in patients with HbA1c levels > 9.0% differed from those with HbA1c levels < 9.0%(29.5% vs.51.4% for osteopenia, 32.8% vs.35.1% for osteoporosis; P = 0.022). The height and weight of the osteoporosis group significantly decreased compared with those of the normal bone mineral density (BMD), whereas the serum BCTX, OC, and PINP levels significantly increased.The SMI, trunk muscles, skeletal muscle parameters, lumbar spine bone mineral content (BMC), lumbar spine BMD, femoral BMC, and femoral BMD decreased significantly in T2DM patients with osteoporosis.Sarcopeniawas associated with a higher height (odds ratio [OR] = 1.524, 95% confidence interval [CI] = 1.196-1.698, P = 0.000), lower body weight (OR = 0.735, 95% CI = 0.640-0.844, P = 0.000), and higher body fat content (OR = 1.211, 95% CI = 1.046-1.402, P = 0.011). Meanwhile, osteoporosis was correlated to a lower SMI (OR = 0.178, 95% CI = 0.044-0.817, P = 0.015).Conclusions: Ahigh HbA1c level was associated with a higher prevalence of sarcopenia and osteoporosis in T2DM patients, and low muscle masswas considered a risk factor for osteoporosis inthis group of patients.

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“…According to one study, sarcopenia is associated with older age, low BMI, and low bone density. (19) Although this explains the increase in fragility fracture rate, (20) items for diagnosing sarcopenia were omitted in this study; as such, an accurate comparison could not be made.…”

Section: Discussionmentioning

confidence: 99%

Association between body mass index and fragility fracture in postmenopausal women: a cross-sectional study using Korean National Health and Nutrition Examination Survey 2008-2009 (KNHANES IV)

Kim

Lee

Kim

et al. 2020

Preprint

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Abstract Background: The present study examined the relationship between body mass index (BMI) and the risk for fragility fractures in postmenopausal Korean women. Method: Among subjects who participated in the 4th National Health and Nutrition Examination Survey (2008-2009), 2114 women ≥ 40 years of age were included. BMI was based on standards set by the Korean Society for the Study of Obesity, as follows: <18.5 kg/m2, underweight; 18.5 ≤ to <25 kg/m2, normal weight; and ≥25 kg/m2, obese. Subjects were also divided into three groups according to the location of fragility fracture: spine, hip, or wrist. Results: The mean (± SD) rate of fragility fracture was significantly different among the three groups: 5.9±2.9% (underweight), 1.1±0.3% (normal weight), and 3.0±0.7% (obese) (p=0.001). After correcting for age, family history, and treatment history of osteoporosis and rheumatoid arthritis, smoking and drinking status, and level of exercise, multivariable regression analysis revealed that the odds ratio for fragility fracture in the underweight group was 5.51 (95% confidence interval [CI] 1.88–16.13) and 3.19 (95% CI 1.51–6.74) in the obese group. After subdividing fragility fractures into vertebral and non-vertebral, the odds ratio for vertebral fracture in the underweight group was 6.05 (95% CI 1.61–22.68) times higher than that in the normal weight group; in the obese group, the non-vertebral fracture odds ratio was 3.73 (95% CI 1.33–10.44) times higher. Analysis of non-vertebral fractures in the obese group revealed an odds ratio for fracture 8.29 (95% CI 1.04–66.37) times higher for hip fracture and 3.73 (95% CI 1.21–11.43) times higher for wrist fracture. Conclusions: Obesity and underweight increased the risk for fragility fractures in postmenopausal Korean women. As such, it is important for this patient population to maintain bone health through proper weight management, sufficient exercise, and regular examination of bone density.

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The association between sarcopenia and osteoporotic vertebral compression refractures

Cited by 43 publications

References 29 publications

Association between body mass index and fragility fracture in postmenopausal women: a cross-sectional study using Korean National Health and Nutrition Examination Survey 2008–2009 (KNHANES IV)

Association between body mass index and fragility fracture in postmenopausal women: a cross-sectional study using Korean National Health and Nutrition Examination Survey 2008–2009 (KNHANES IV)

A Cross-sectional Study: Association Between sarcopenia and Osteoporosis in Type 2 Diabetes Mellitus Patients With a High Glycated Hemoglobin Level

Association between body mass index and fragility fracture in postmenopausal women: a cross-sectional study using Korean National Health and Nutrition Examination Survey 2008-2009 (KNHANES IV)

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