The association between sarcopenia and functional outcomes among older patients with hip fracture undergoing in-hospital rehabilitation

Landi, Francesco; Calvani, Riccardo; Ortolani, Elena; Salini, Silvia; Martone, Anna Maria; Santoro, Luca; Santoliquido, Angelo; Sisto, Alex; Picca, Anna; Marzetti, Emanuele

doi:10.1007/s00198-017-3929-z

Cited by 97 publications

(82 citation statements)

References 35 publications

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“…In the present study, we considered the risk of a cumulative number of geriatric conditions as a proxy of vulnerability and showed its association with lower HGS in both female and male patients, and absolute and relative muscle mass at admission in male patients. A recent study in older inpatients showed that low muscle strength and muscle mass at admission leads to an increased risk of incomplete functional recovery during inhospital rehabilitation [25] , likely mediated by the increased vulnerability of these patients. Lower relative SMM at admission was only associated with being at risk of a higher cumulative number of geriatric conditions after adjusting for weight.…”

Section: Discussionmentioning

confidence: 99%

Muscle Strength and Muscle Mass in Older Patients during Hospitalization: The EMPOWER Study

et al. 2017

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Background: Low muscle strength and muscle mass are associated with an increased length of hospital stay and higher mortality rate in inpatients. To what extent hospitalization affects muscle strength and muscle mass is unclear. Objective: We aimed to assess muscle strength and muscle mass at admission and during hospitalization in older patients and its relation with being at risk of geriatric conditions. Methods: The EMPOWER study included patients aged 70 years and older, admitted to 4 wards of the VU University Medical Center in the Netherlands between April and December 2015. At admission, patients were screened for being at risk of 4 geriatric conditions: delirium, falls, malnutrition, and functional disability. At admission and at discharge, muscle strength and muscle mass were assessed. Results: A total of373 patients (mean age, standard deviation [SD]: 79.6, 6.38 years) were included at admission, and 224 patients (mean age, SD: 80.1, 6.32 years) at discharge. At admission, lower muscle strength in both female and male patients and low muscle mass in male patients were associated with being at risk of a higher cumulative number of geriatric conditions. Muscle strength increased during hospitalization, but no change in muscle mass was observed. Changes in muscle measures were not associated with being at risk of geriatric conditions. Discussion: Older patients with lower muscle strength and muscle mass at admission were at risk of a higher cumulative number of geriatric conditions. However, being at risk of geriatric conditions did not forecast further decrease in muscle strength and muscle mass during hospitalization

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Section: Discussionmentioning

confidence: 99%

Muscle Strength and Muscle Mass in Older Patients during Hospitalization: The EMPOWER Study

et al. 2017

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“…Our study applied both the ESPEN consensus and guidelines to describe the influence of basic and etiology-based diagnoses of malnutrition on clinical outcomes during hospitalization for postacute care. As malnutrition and disability are linked bidirectionally to mobility and disability (Landi et al, 2017), an early identification of malnourished patients would help the multidisciplinary care team to set realistic aims, plan therapeutic strategies, and provide the patient and caregivers with more precise information. The influence of the ESPEN consensus on clinical outcomes was recently reported in geriatric patients with diabetes in acute care (Sanz-París et al, 2016), but its influence on clinical and rehabilitation outcomes during hospitalization in postacute care has not previously been described…”

Section: Discussionmentioning

confidence: 99%

Malnutrition in postacute geriatric care: Basic ESPEN diagnosis and etiology based diagnoses analyzed by length of stay, in-hospital mortality, and functional rehabilitation indexes

Sánchez-Rodríguez

Marco

Annweiler

et al. 2017

Archives of Gerontology and Geriatrics

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“…Women undergo an accelerated loss of muscle mass at an earlier age than men, beginning at the time of menopause [12] ; however, it appears men lose more muscle mass over the course of their lifetime compared to females [13] . Sarcopenia is defined by a decline in both quality and quantity of muscle [14] , and is a major contributor to decline in physical function and development of frailty with aging [15, 16] . Although there is no international consensus on the operational definition of sarcopenia [14] , a well-accepted definition based on muscle mass alone uses an appendicular skeletal mass index (ASMI) defined as either appendicular lean mass, measured by dual energy X-ray absorptiometry (DXA) [17] , or appendicular skeletal muscle mass measured by MRI (ASM) [18] , both adjusted for height [19, 20] .…”

Section: Sarcopeniamentioning

confidence: 99%

Geriatric syndromes

Hawkins

Brown²,

Margolick

et al. 2017

Aids

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HIV infection, in many circumstances, can now be managed as a chronic disease due to the marked increase in life expectancy since the introduction of combination antiretroviral therapy (cART). As the patients who first had access to cART age into their 50s and 60s, the effects of chronic HIV infection on health have become an important research focus in HIV infection. People living with HIV appear to exhibit an earlier occurrence of some aging-related conditions compared to people without HIV, in part due to higher rates of co-morbidities, high risk behaviors (e.g., smoking, substance use), chronic immune activation, inflammation and ART-specific factors. Some studies have even suggested an earlier than expected appearance of the “geriatric syndromes”, which are complex medical syndromes of older adults that are associated with morbidity and mortality. The geriatric syndromes include a wide variety of disease processes ranging from incontinence and dementia to impairments in physical function. This review will focus on one geriatric syndrome, sarcopenia, in older HIV-infected populations and its relation to other aging syndromes, including frailty and falls. The contribution of HIV itself, ART exposure, and specific comorbidities, and the importance of early recognition and prevention of these aging syndromes will be highlighted.

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The association between sarcopenia and functional outcomes among older patients with hip fracture undergoing in-hospital rehabilitation

Abstract: These findings support the systematic assessment of sarcopenia among older adults receiving rehabilitation programs to assist in the development of personalized treatment plans aimed at improving functional outcomes.

Cited by 97 publications

References 35 publications

Muscle Strength and Muscle Mass in Older Patients during Hospitalization: The EMPOWER Study

Muscle Strength and Muscle Mass in Older Patients during Hospitalization: The EMPOWER Study

Malnutrition in postacute geriatric care: Basic ESPEN diagnosis and etiology based diagnoses analyzed by length of stay, in-hospital mortality, and functional rehabilitation indexes

Geriatric syndromes

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