Abstract:Background: In this study, we aimed to investigate the association between polymorphisms in the RNF213 and MMP3 genes and Moyamoya disease (MMD) and to screen susceptibility genes for families with MMD.Methods: The mutation of RNF213 gene (rs112735431,rs148731719) and MMP3 gene rs3025058 were detected by first generation sequencing and CRISPR-Cas12a. The genetic susceptibility genes of MMD families samples were studied by whole exome sequencing (WES). Results: The application of CRISPR-Cas12a and Sanger sequen… Show more
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