The Association Between Rheumatoid Arthritis and Atrial Fibrillation: Epidemiology, Pathophysiology and Management

Qian, Yezhou; Fei, Z.; Nian, Feige

doi:10.2147/ijgm.s406926

Cited by 3 publications

(3 citation statements)

References 128 publications

(160 reference statements)

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“…( Current findings suggest that rheumatoid arthritis can cause atrial remodeling and induce the development and maintenance of AF (85). Accordingly, some scholars found that resveratrol can reverse rheumatoid arthritis-induced atrial structural and metabolic remodeling, then slow down the development of AF (86).…”

Section: Chinese Herbs Model Intervention Cellular and Molecular Mech...mentioning

confidence: 99%

“…Zhong et al evaluated the therapeutic effect of resveratrol in reducing the occurrence of AF in a heart failure model and explored the underlying mechanisms, finding that myocardial fibrosis was significantly reduced in the resveratrol group, ion channels including Kv1.4, Kv1.5, KvLQT1, Kir2.1, and Nav1.5 were significantly upregulated, and PI3K, AKT, and eNOS mRNA and protein expression were also significantly enhanced ( 84 ). Current findings suggest that rheumatoid arthritis can cause atrial remodeling and induce the development and maintenance of AF ( 85 ). Accordingly, some scholars found that resveratrol can reverse rheumatoid arthritis-induced atrial structural and metabolic remodeling, then slow down the development of AF ( 86 ).…”

Section: Chinese Herbal Medicines With Preventive and Curative Effect...mentioning

confidence: 99%

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The application and mechanism of Chinese medicine in the upstream treatment of atrial fibrillation

Liu,

Mao,

Zhao

et al. 2023

Front. Cardiovasc. Med.

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Upstream treatment of atrial fibrillation (AF, for short) is a new approach to the prevention and treatment of AF with non-antiarrhythmic drugs, which is essentially primary and secondary prevention of AF. The former refers to the prevention of AF by controlling risk factors such as diabetes, hypertension, and heart failure before AF occurs, and the latter mainly refers to targeting ion channels, inflammation, oxidative stress, and other pathways to reduce or reverse atrial electrical and structural remodeling, reduction of AF load, and reduction of the chance of AF occurrence or progression. More and more studies have shown that many traditional Chinese medicines, active ingredients of Chinese medicines, and Chinese herbal formulas have definite effects on the upstream treatment of AF, but their mechanisms of action are different. Therefore, we summarized the relevant literature on the application and mechanisms of Chinese medicine on the upstream treatment of AF in recent years, hoping to be helpful for subsequent studies.

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Section: Chinese Herbs Model Intervention Cellular and Molecular Mech...mentioning

confidence: 99%

Section: Chinese Herbal Medicines With Preventive and Curative Effect...mentioning

confidence: 99%

The application and mechanism of Chinese medicine in the upstream treatment of atrial fibrillation

Liu,

Mao,

Zhao

et al. 2023

Front. Cardiovasc. Med.

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“…Фибрилляция предсердий (ФП) является наиболее распространённой сердечной аритмией со значительным увеличением заболеваемости и смертности во всем мире. В литературе имеются указания, что РА ассоциирован с повышенной частотой сердечных аритмий, таких как ФП [36]. В датском общенациональном когортном исследовании было показано, что частота ФП у пациентов с РА на 40% выше, чем в общей популяции [37].…”

Section: фибрилляция предсердийunclassified

Disorders of cardiac conduction and rhythm in patients with rheumatoid arthritis

Rebrov

2023

jour

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The article presents data on the frequency and features of the development of various cardiac conduction and rhythm disorders in patients with rheumatoid arthritis, the mechanisms of development of these disorders, and discusses the role of inflammation, atrial remodeling, dysfunction of the autonomic nervous system, activation of the renin-angiotensin system, endothelial dysfunction and other factors.

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Systematic druggable genome-wide Mendelian randomization identifies novel therapeutic targets or repurposing opportunities for rheumatoid arthritis

Cai,

Wang,

Yuan

et al. 2023

Preprint

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Background Rheumatoid arthritis (RA) is a common autoimmune inflammatory disease. Currently, a complete cure for RA is still unavailable. Mendelian randomization (MR) has emerged as a valuable tool for identifying potential therapeutic targets or drug repurposing opportunities for certain diseases. Therefore, our aim was to identify novel effective targets or drug repurposing opportunities for RA and analyze their mechanisms and potential side effects. Methods A MR integrating the identified druggable genes was used to evaluate the causal effects of druggable gene cis-expression quantitative trait loci (cis-eQTLs) on RA, while additional RA cohort was employed for validation. Colocalization analysis was performed to determine the probability of shared causal variants between the identified targets and RA. The protein-protein interaction network analysis was conducted to explore associations between the identified druggable genes and current RA drug targets. The MR and colocalization analyses were used to assess the potential side effects of the identified targets in RA treatment. Results Nine druggable genes (TYK2, PTPN22, ATP2A1, APOM, RXRB, NOTCH4, HLA-DRA, CCR6, and CTLA4) showed significant MR results in both the training cohort (p<1.99E-05) and validation cohort (p<0.0025). Colocalization analysis indicated that cytotoxic T-lymphocyte-associated protein 4 (CTLA4) and RA (PP.H4.abf=0.98), as well as C-C motif chemokine receptor 6 (CCR6) and RA (PP.H4.abf=0.99), shared the same causal variant. Hence, these two genes were identified as the final therapeutic targets. Furthermore, CTLA4 and CCR6 interacted with the current RA drug targets. Subsequent MR analysis revealed that genetically proxied activation of CTLA4 and inhibition of CCR6 might decrease the risk of hypothyroidism but increase the risk of malignant skin neoplasm. Additionally, genetically proxied activation of CTLA4 may also reduce the risk of type 1 diabetes. Conclusions This study supports the idea that targeting the activation of CTLA4 and the inhibition of CCR6 may reduce the risk of RA with fewer side effects, and highlights the potential of CTLA4 and CCR6 as promising druggable targets for RA treatment.

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The Association Between Rheumatoid Arthritis and Atrial Fibrillation: Epidemiology, Pathophysiology and Management

Cited by 3 publications

References 128 publications

The application and mechanism of Chinese medicine in the upstream treatment of atrial fibrillation

The application and mechanism of Chinese medicine in the upstream treatment of atrial fibrillation

Disorders of cardiac conduction and rhythm in patients with rheumatoid arthritis

Systematic druggable genome-wide Mendelian randomization identifies novel therapeutic targets or repurposing opportunities for rheumatoid arthritis

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